Brucellosis: an Overview

Abstract

Brucellosis remains a major zoonosis worldwide. Although many countries have eradicated Brucella abortus from cattle, in some areas Brucella melitensis has emerged as a cause of infection in this species as well as in sheep and goats. Despite vaccination campaigns with the Rev 1 strain, B. melitensis remains the principal cause of human brucellosis. Brucella suis is also emerging as an agent of infection in cattle, thus extending its opportunities to infect humans. The recent isolation of distinctive strains of Brucella from marine mammals has extended its ecologic range. Molecular genetic studies have demonstrated phylogenetic affiliation to Agrobacterium, Phyllobacterium, Ochrobactrum, and Rhizobium. Polymerase chain reaction and gene probe development may provide more effective typing methods. Pathogenicity is related to production of lipopolysaccharides containing a poly N-formyl perosamine O chain, CuZn superoxide dismutase, erythrlose phosphate dehydrogenase, stress-induced proteins related to intracellular survival, and adenine and guanine monophosphate inhibitors of phagocyte functions. Protective immunity is conferred by antibody to lipopolysaccharide and T-cell-mediated macrophage activation triggered by protein antigens. Diagnosis still centers on isolation of the organism and serologic test results, especially enzyme immunoassay, which is replacing other methods. Polymerase chain reaction is also under evaluation. Therapy is based on tetracyclines with or without rifampicin, aminoglycosides, or quinolones. No satisfactory vaccines against human brucellosis are available, although attenuated purE mutants appear promising.

References 51

1. 1.

   Akova M., Uzun O., Akalin H. E., Hayran M., Unal S., Gür D. Quinolones in treatment of human brucellosis: comparative trial of ofloxacin-rifampin versus doxycycline-rifampin. Antimicrob Agents Chemother. 1993;37(9):1831-1834.

   Not in our library10.1128/aac.37.9.1831

2. 2.

   Allardet-Servent A., Bourg G., Ramuz M., Pages M., Bellis M., Roizes G. DNA polymorphism in strains of the genus Brucella. J Bacteriol. 1988;170(10):4603-4607.

   Not in our library10.1128/jb.170.10.4603-4607.1988

3. 3.

   Araj G. F., Lulu A. R., Mustafa M. Y., Khateeb M. I. Evaluation of ELISA in the diagnosis of acute and chronic brucellosis in human beings. J Hyg (Lond). 1986;97(3):457-469.

   Not in our library10.1017/s0022172400063634

4. 4.

   Ariza J., Gudiol F., Pallarés R., Rufí G., Fernández-Viladrich P. Comparative trial of rifampin-doxycycline versus tetracycline-streptomycin in the therapy of human brucellosis. Antimicrob Agents Chemother. 1985;28(4):548-551.

   Not in our library10.1128/aac.28.4.548

5. 5.

   Ariza J., Pellicer T., Pallarés R., Foz A., Gudiol F. Specific antibody profile in human brucellosis. Clin Infect Dis. 1992;14(1):131-140.

   Not in our library10.1093/clinids/14.1.131

6. 6.

   Bachrach G., Banai M., Bardenstein S., Hoida G., Genizi A., Bercovier H. Brucella ribosomal protein L7/L12 is a major component in the antigenicity of brucellin INRA for delayed-type hypersensitivity in brucella-sensitized guinea pigs. Infect Immun. 1994;62(12):5361-5366.

   Not in our library10.1128/iai.62.12.5361-5366.1994

7. 7.

   Banai M., Mayer I., Cohen A. Isolation, identification, and characterization in Israel of Brucella melitensis biovar 1 atypical strains susceptible to dyes and penicillin, indicating the evolution of a new variant. J Clin Microbiol. 1990;28(5):1057-1059.

   Not in our library10.1128/jcm.28.5.1057-1059.1990

8. 8.

   Bundle D. R., Cherwonogrodzky J. W., Gidney M. A., Meikle P. J., Perry M. B., Peters T. Definition of Brucella A and M epitopes by monoclonal typing reagents and synthetic oligosaccharides. Infect Immun. 1989;57(9):2829-2836.

   Not in our library10.1128/iai.57.9.2829-2836.1989

9. 9.

   Canning P. C., Roth J. A., Deyoe B. L. Release of 5'-guanosine monophosphate and adenine by Brucella abortus and their role in the intracellular survival of the bacteria. J Infect Dis. 1986;154(3):464-470.

   Not in our library10.1093/infdis/154.3.464

10. 10.

    Caron E., Peyrard T., Köhler S., Cabane S., Liautard J. P., Dornand J. Live Brucella spp. fail to induce tumor necrosis factor alpha excretion upon infection of U937-derived phagocytes. Infect Immun. 1994;62(12):5267-5274.

    Not in our library10.1128/iai.62.12.5267-5274.1994

11. 11.

    Cellier M. F., Teyssier J., Nicolas M., Liautard J. P., Marti J., Sri Widada J. Cloning and characterization of the Brucella ovis heat shock protein DnaK functionally expressed in Escherichia coli. J Bacteriol. 1992;174(24):8036-8042.

    Not in our library10.1128/jb.174.24.8036-8042.1992

12. 12.

    Cieslak T. J., Robb M. L., Drabick C. J., Fischer G. W. Catheter-associated sepsis caused by Ochrobactrum anthropi: report of a case and review of related nonfermentative bacteria. Clin Infect Dis. 1992;14(4):902-907.

    Not in our library10.1093/clinids/14.4.902

13. 13.

    Cloeckaert A., Verger J. M., Grayon M., Grépinet O. Restriction site polymorphism of the genes encoding the major 25 kDa and 36 kDa outer-membrane proteins of Brucella. Microbiology. 1995;141(Pt 9):2111-2121.

    Not in our library10.1099/13500872-141-9-2111

14. 14.

    Corbel M. J. Identification of dye-sensitive strains of Brucella melitensis. J Clin Microbiol. 1991;29(5):1066-1068.

    Not in our library10.1128/jcm.29.5.1066-1068.1991

15. 15.

    Corbel M. J. The immunogenic activity of ribosomal fractions derived from Brucella abortus. J Hyg (Lond). 1976;76(1):65-74.

    Not in our library10.1017/s0022172400054954

16. 16.

    Corbel M. J., Thomas E. L. Use of phage for the identification of Brucella canis and Brucella ovis cultures. Res Vet Sci. 1985;38(1):35-40.

    Not in our library

17. 17.

    Corbel M. J. Vaccines against bacterial zoonoses. J Med Microbiol. 1997;46(4):267-269.

    Not in our library10.1099/00222615-46-4-267

18. 18.

    Crawford R. M., Van De Verg L., Yuan L., Hadfield T. L., Warren R. L., Drazek E. S., Houng H. H., Hammack C., Sasala K., Polsinelli T. Deletion of purE attenuates Brucella melitensis infection in mice. Infect Immun. 1996;64(6):2188-2192.

    Not in our library10.1128/iai.64.6.2188-2192.1996

19. 19.

    Da Costa M., Guillou J. P., Garin-Bastuji B., Thiébaud M., Dubray G. Specificity of six gene sequences for the detection of the genus Brucella by DNA amplification. J Appl Bacteriol. 1996;81(3):267-275.

    Not in our library10.1111/j.1365-2672.1996.tb04328.x

20. 20.

    Douglas J. T., Rosenberg E. Y., Nikaido H., Verstreate D. R., Winter A. J. Porins of Brucella species. Infect Immun. 1984;44(1):16-21.

    Not in our library10.1128/iai.44.1.16-21.1984

21. 21.

    Ewalt D. R., Payeur J. B., Martin B. M., Cummins D. R., Miller W. G. Characteristics of a Brucella species from a bottlenose dolphin (Tursiops truncatus). J Vet Diagn Invest. 1994;6(4):448-452.

    Not in our library10.1177/104063879400600408

22. 22.

    Ficht T. A., Bearden S. W., Sowa B. A., Adams L. G. DNA sequence and expression of the 36-kilodalton outer membrane protein gene of Brucella abortus. Infect Immun. 1989;57(11):3281-3291.

    Not in our library10.1128/iai.57.11.3281-3291.1989

23. 23.

    Ficht T. A., Husseinen H. S., Derr J., Bearden S. W. Species-specific sequences at the omp2 locus of Brucella type strains. Int J Syst Bacteriol. 1996;46(1):329-331.

    Not in our library10.1099/00207713-46-1-329

24. 24.

    Goldbaum F. A., Leoni J., Wallach J. C., Fossati C. A. Characterization of an 18-kilodalton Brucella cytoplasmic protein which appears to be a serological marker of active infection of both human and bovine brucellosis. J Clin Microbiol. 1993;31(8):2141-2145.

    Not in our library10.1128/jcm.31.8.2141-2145.1993

25. 25.

    Goldbaum F. A., Morelli L., Wallach J., Rubbi C. P., Fossati C. A. Human brucellosis: immunoblotting analysis of three Brucella abortus antigenic fractions allows the detection of components of diagnostic importance. Medicina (B Aires). 1991;51(3):227-232.

    Not in our library

26. 26.

    Jumas-Bilak E., Maugard C., Michaux-Charachon S., Allardet-Servent A., Perrin A., O'Callaghan D., Ramuz M. Study of the organization of the genomes of Escherichia coli, Brucella melitensis and Agrobacterium tumefaciens by insertion of a unique restriction site. Microbiology. 1995;141(Pt 10):2425-2432.

    Not in our library10.1099/13500872-141-10-2425

27. 27.

    Khuri-Bulos N. A., Daoud A. H., Azab S. M. Treatment of childhood brucellosis: results of a prospective trial on 113 children. Pediatr Infect Dis J. 1993;12(5):377-381.

    Not in our library10.1097/00006454-199305000-00005

28. 28.

    Kolman S., Maayan M. C., Gotesman G., Rozenszajn L. A., Wolach B., Lang R. Comparison of the Bactec and lysis concentration methods for recovery of Brucella species from clinical specimens. Eur J Clin Microbiol Infect Dis. 1991;10(8):647-648.

    Not in our library10.1007/bf01975817

29. 29.

    Lin J., Ficht T. A. Protein synthesis in Brucella abortus induced during macrophage infection. Infect Immun. 1995;63(4):1409-1414.

    Not in our library10.1128/iai.63.4.1409-1414.1995

30. 30.

    Luzzi G. A., Brindle R., Sockett P. N., Solera J., Klenerman P., Warrell D. A. Brucellosis: imported and laboratory-acquired cases, and an overview of treatment trials. Trans R Soc Trop Med Hyg. 1993;87(2):138-141.

    Not in our library10.1016/0035-9203(93)90460-8

31. 31.

    Mantur B. G., Mangalgi S. S., Mulimani M. Brucella melitensis--a sexually transmissible agent? Lancet. 1996;347(9017):1763-1763.

    Not in our library10.1016/s0140-6736(96)90839-9

32. 32.

    Matar G. M., Khneisser I. A., Abdelnoor A. M. Rapid laboratory confirmation of human brucellosis by PCR analysis of a target sequence on the 31-kilodalton Brucella antigen DNA. J Clin Microbiol. 1996;34(2):477-478.

    Not in our library10.1128/jcm.34.2.477-478.1996

33. 33.

    Michaux S., Paillisson J., Carles-Nurit M. J., Bourg G., Allardet-Servent A., Ramuz M. Presence of two independent chromosomes in the Brucella melitensis 16M genome. J Bacteriol. 1993;175(3):701-705.

    Not in our library10.1128/jb.175.3.701-705.1993

34. 34.

    Minnick M. F., Stiegler G. L. Nucleotide sequence and comparison of the 5S ribosomal RNA genes of Rochalimaea henselae, R.quintana and Brucella abortus. Nucleic Acids Res. 1993;21(10):2518-2518.

    Not in our library10.1093/nar/21.10.2518

35. 35.

    Mustafa A. A., Abusowa M. Field-oriented trial of the Chinese Brucella suis strain 2 vaccine on sheep and goats in Libya. Vet Res. 1993;24(5):422-429.

    Not in our library

36. 36.

    O'Hara M. J., Collins D. M., de Lisle G. W. Restriction endonuclease analysis of Brucella ovis and other Brucella species. Vet Microbiol. 1985;10(5):425-429.

    Not in our library10.1016/0378-1135(85)90024-0

37. 37.

    Oliveira S. C., Splitter G. A. Immunization of mice with recombinant L7/L12 ribosomal protein confers protection against Brucella abortus infection. Vaccine. 1996;14(10):959-962.

    Not in our library10.1016/0264-410x(96)00018-7

38. 38.

    Potasman I., Even L., Banai M., Cohen E., Angel D., Jaffe M. Brucellosis: an unusual diagnosis for a seronegative patient with abscesses, osteomyelitis, and ulcerative colitis. Rev Infect Dis. 1991;13(6):1039-1042.

    Not in our library10.1093/clinids/13.6.1039

39. 39.

    Relman D. A., Lepp P. W., Sadler K. N., Schmidt T. M. Phylogenetic relationships among the agent of bacillary angiomatosis, Bartonella bacilliformis, and other alpha-proteobacteria. Mol Microbiol. 1992;6(13):1801-1807.

    Not in our library10.1111/j.1365-2958.1992.tb01352.x

40. 40.

    Rigby C. E., Fraser A. D. Plasmid transfer and plasmid-mediated genetic exchange in Brucella abortus. Can J Vet Res. 1989;53(3):326-330.

    Not in our library

Cited by papers we hold 10

• A new candidate vaccine for human brucellosis based on influenza viral vectors: a preliminary investigation for the development of an immunization schedule in a guinea pig model · 2021
  Not checked
• Bovine brucellosis – a comprehensive review · 2021
  No notice
• Non-adaptive Evolution of Trimeric Autotransporters in Brucellaceae · 2020
  Not checked
• Comparisons of brucellosis between human and veterinary medicine · 2018
  No notice
• Identification of a Novel Small Non-Coding RNA Modulating the Intracellular Survival of Brucella melitensis · 2015
  Not checked
• Literature Mining and Ontology based Analysis of Host-Brucella Gene-Gene Interaction Network · 2015
  Not checked
• The Rose Bengal Test in Human Brucellosis: A Neglected Test for the Diagnosis of a Neglected Disease · 2011
  No notice
• Perspectives for the Treatment of Brucellosis in the 21st Century: The Ioannina Recommendations · 2007
  No notice
• Characterisation of the genetic diversity of Brucella by multilocus sequencing · 2007
  No notice
• Isolamento e tipizzazione di Brucella melitensis biovar 3 da emocoltura, utilizzando il sistema di rilevazione microbica Bact/Alert · 2006
  Not checked

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.