Does cotinine act upon reactive oxygen species and peroxidases?

Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world.It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use oftobacco is closely associated with lung disease, morphological leukocyte modification and generationof oxidant species. The aim of this study was to look for a possible relationship between cotinine,oxidant species generation and oxidative processes. After studying the action of cotinine in somechemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase andhorseradish peroxidase), we concluded that cotinine does not act directly upon H2O2, HOCl, taurinechloramines, horseradish peroxidase or myeloperoxidase.

Abstract licence: CC BY

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