Swiss Science Concentrates

Quantification of Total N-Nitrosamine Concentrations in Aqueous Samples via UV-Photolysis and Chemiluminescence Detection of Nitric Oxide F. Breider and U. von Gunten*, Anal.Chem.2017, 89, 1574.EPF Lausanne and Eawag, Dübendorf N-nitrosamines are potent mutagens and carcinogens that can be formed during water and wastewater treatment as well as in the gastric fluids by endogenous nitrosation.The analysis of the total N-nitrosamine concentration can indicate whether N-nitrosodimethylamine and other specific nitrosamines of current interest are dominant or minor components of the total N-nitrosamine pool.Breider and von Gunten now present a significant improvement of the measurement of total N-nitrosamines concentrations in aqueous samples by coupling photolytic cleavage of the N-N bond with chemiluminescence detection of nitric oxide.The method can be potentially used for numerous applications in the fields of water quality and treatment as well as in biomedical research.

Abstract licence: CC BY-NC

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