Daring the Challenge and Thinking Big: The Value of Early Process R&D
Stefan Abele, Jacques-Alexis Funel, Gunther Schmidt and 3 more
CHIMIA · 2016
doi:10.2533/chimia.2016.502 (opens in a new tab)
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Abstract
The production of the L/T channel blocker ACT-280778 required the enantiomerically pure 5-phenylbicyclo[2.2.2]oct-5-en-2-one (1) as key building block. As the published routes towards 1 are very low yielding (
Abstract licence: CC BY-NC
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