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On the Importance of Mathematical Methods for Analysis of MALDI-Imaging Mass Spectrometry Data

Trede Dennis, Kobarg Jan Hendrik, Oetjen Janina and 3 more

Journal of Integrative Bioinformatics · 2012

doi:10.2390/biecoll-jib-2012-189 (opens in a new tab)

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Abstract

In the last decade, matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS), also called as MALDI-imaging, has proven its potential in proteomics and was successfully applied to various types of biomedical problems, in particular to histopathological label-free analysis of tissue sections. In histopathology, MALDI-imaging is used as a general analytic tool revealing the functional proteomic structure of tissue sections, and as a discovery tool for detecting new biomarkers discriminating a region annotated by an experienced histologist, in particular, for cancer studies.

Abstract licence: CC BY

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