Iga nephropathy

IgA nephropathy is glomerular disease first described in 1968 by Berger, named after him Morbus Berger. The disease is characterized by the presence of IgA dominant or codominant imunoglobuline deposits in glomerular mesangium which can be demostrated by immunofluorescence. Clinical manifestations of IgA nephropathy in the majority of cases is hematuria which can be macro or microskopic, isolated or combined with proteinuria which can be of nephrotic range. In some cases nephrotic syndrome can be the first clinical presentatio. In 10% renal insuficiency can be present at the onset of the disease. By light microscopy IgA can manifest any of the histologie phenotypes of immune complex mediated prolifferative glomerulonephritis. According to light microscopy findings a classification systeme have been used to categorize the histologie patterns of IgA nephropathy. Glomerular changes in IgA nephropathy are prolifferative and can be focal or diffuse accompanied by crescentic formation in many cases. Immune deposits seen by electron microscopy appear as electron dense deposites most numerous in mesangium.

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