Antimicrobial activity of some isatin-3-thiosemicarbazone complexes
Konstantinović Sandra S., Radovanović Blaga C., Sovilj Sofija P. and 1 more
Journal of the Serbian Chemical Society · 2008
doi:10.2298/jsc0801007k (opens in a new tab)
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Abstract
Isatin-3-thiosemicarbazone complexes with Co(II), Ni(II), Cu(II), Zn(II), Hg(II) and Pd(II) were synthesized and evaluated for their antimicrobial activity against 7 pathogenic bacteria and 4 fungi. The complexes have an enhanced activity compared to the ligand due to transition metal involved in coordination. The anti-amoebic activity in vitro was evaluated against the HM1:IMSS strain of Entamoeba histolytica and the results were compared with the standard drug, metronidazole. The preliminary test results showed that the complexes had better anti-amoebic activity than their respective ligands. Moreover, the complexes showed better inhibition of the test organism.
Abstract licence: CC BY
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