Synthesis of the 4’-desmethoxy analogue of RU79115
Mušicki Branislav, Periers Anne-Marie, Tessot Nicole and 1 more
Journal of the Serbian Chemical Society · 2004
doi:10.2298/jsc0411855m (opens in a new tab)
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Abstract
The synthesis, and biological activity in vitro of the 4’-desmethoxy analogue (3) of RU 79115 (2) is described. Comparison of the biological activity of the two analogues clearly indicated the importance of the 4’-methoxy group in conferring good gyrase B inhibitory activity as well as antibacterial activity.
Abstract licence: CC BY
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