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Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane

Opsenica Dejan M., Pocsfalvi Gabriella, Milhous Wilburk K. and 1 more

Journal of the Serbian Chemical Society · 2002

doi:10.2298/jsc0207465o (opens in a new tab)

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Abstract

An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).

Abstract licence: CC BY

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