Theoretical consideration and application of the SP and SP' scales in RP chromatographic systems in which Everett’s equation is valid

It is shown that in the case of ODS and less polar modifiers the log k values are a linear function of the SP’parameters. This findings differ from earlier investigated systems, in which a linear dependence between log k and SP parameters (SP = log SP’) was found. Both linear relationships have been analyzed and the corresponding possible separation mechanisms have been considered. In addition, the advantages of normalization of both scales are shown and how then they can be applied in the investigation of substances congenerity.

Abstract licence: CC BY

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