Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure
Li Wang, Kai Gao, Dan Wang
Iranian Journal of Basic Medical Sciences · 2018
doi:10.22038/ijbms.2018.29294.7076 (opens in a new tab)
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Abstract
Objective(s): Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were randomly divided into sham operation group (Sham group), CHF model group, and CHF exercise group (Exercise-CHF group). Results: Our data showed that when compared to the Sham group, the left ventricular systolic pressure (LVSP), myocardial glycogen content, and expression levels of key components of AMP-activated protein kinase (AMPK) pathway were decreased significantly (P
Abstract licence: CC BY-NC
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