Antifungal activity of some toothpastes and antiseptic solutions against yeasts isolated from the oral cavity of cancer radiated patients

This study aimed to investigate the antifungal efficacy of different types of toothpaste and<br />some antiseptic solutions with varying concentrations against yeast isolated from the oral cavity<br />of radiated patients suffering from head and neck cancer in radiotherapy unit in Suez Canal<br />University teaching’s hospital, Egypt. Eight different species of yeast were isolated<br />taxonomically, assigned to 1 phylum, two classes, one order, and three families and identified<br />phenotypically. The antifungal activity of five kinds of toothpaste and three antiseptic solutions<br />were investigated by agar well diffusion method against the eight isolated yeasts namely:<br />Candida glabrata, C. albicans, C. tropicalis, C. kefyr, C. guilliermondii, C. parapsilosis,<br />Dipodascus geotrichum and Geotrichum beigelii and expressed as the value of the clear zone<br />diameter, however, Their activity was expressed by minimum inhibitory concentration (MIC).<br />Results showed that toothpaste no 1, 3, 4 and 5 were effective against all tested taxa by variable<br />inhibitory degrees. However, no. 2 showed efficacy only against C. glabrata, C. guilliermondii,<br />and C. parapsilosis, Antiseptic solution no 1 showed the highest efficacy against all tested<br />species except C. kefyr while no. 2 was effective against all the tested species except two taxa<br />and finally no. 3 exhibited good antifungal activity against all the tested taxa. In conclusion, we<br />recommended the use of toothpaste contained sodium monofluorophosphate, or sodium fluoride,<br />as an active component followed by a mouthwash which contained Chlorohexidine or<br />Cetylpridinium or miswak as active components to prevent colonization and development of oral<br />candidiasis, especially in cancer patients.

Abstract licence: CC BY

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