EFFECTS OF TRANEXAMIC ACID IN THE WIDE RECONSTRUCTIVE SURGERY ON HIP JOINT

The wide surgery on hip joint is followed by the blood loss, local and systematic inflammatory response. Tranexamic acid is widely used in surgery for conservative homeostasis and its anti-inflammatory effect is also well known. The purpose: to justify the dosing regimen of tranexamic acid from the position of minimum blood loss and inflammatory response. Materials and methods: 32 patients from the control group received standard therapy with tranexamic acid at the dose of 20 mg/kg intravenously twice a day: 30 minutes prior to the surgery and in 6 hours since the 1st administration; in the main group (29 patients) the standard regimen was supplemented by intra-operative administration – 10 mg per kg-1 ∙ h-1. Results. The volume of the intra-surgery, drainage, general and estimated peri-operative blood loss was not statistically different between two groups. The level of pro-inflammatory and anti-inflammatory cytokines was higher in the drainage blood compared to the peripheral one (p < 0.001). The concentration of soluble receptors to IL-6 and FNO-α was statistically and clinically confidently higher in the control group compared to the main one at the majority stages of the study (p < 0.05). Conclusion. Tranexamic acid possesses anti-inflammatory action regardless of the dose.

Abstract licence: CC BY

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.