Anticarcinogenesis effect of Gynura procumbens (Lour) Merr on tongue carcinogenesis in 4NQO-induced rat

<span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>In Indonesia Gynura procumbens (Lour) Merr leaves have been long used as various cancers medication. Many in vitro and in </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>vivo studies have demonstrated anticarcinogenesis of ethanol extract of Gynura procumbens leaves. The aim of this study was to </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>investigate the anticarcinogenesis of the ethanol extract of Gynura procumbens leaves on 4 nitroquinoline 1-oxide (4NQO)-induced </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>rat tongue carcinogenesis. Fifty six 4 week old male Sprague Dawley rats were used in this study and divided into 7 groups. Group </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>1, 2 and 3 were lingually induced by 4NQO for 8 weeks. In groups 2 and 3 the extract was given simultaneously with or after 4NQO </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>induction finished, each for 10 weeks and 26 weeks, respectively. Groups 4, 5 and 6 were induced by 4NQO for 16 weeks. However, </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>in groups 5 and 6 the extract was given as well simultaneously with or after the 4NQO induction, each for 18 weeks, respectively. </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>Group 7 served as the as untreated control group. The results from microscopical assessment showed that tongue squamous cell </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>carcinomas (SCC) developed in 100% (3/3) of group 1. However, only 33.3% (2/6) and 25% (2/8) of rats in groups 2 and 3, </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>respectively demonstrated tongue SCC. Among groups 4, 5 and 6, no significant difference of tongue SCC incidence was observed. </em><span style="font-family: Tribune,Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>From these results it is apparent that the ethanol extract of Gynura procumbens leaves could inhibit the progression of 4NQOinduced rat tongue carcinogenesis in the initiation phase.</em></span></span></span></span></span></span></span></span></span></span><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" /></span>

Abstract licence: CC BY-SA

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