TGF-β signaling in C. elegans

Abstract

Transforming Growth Factor-β (TGF-β) superfamily ligands regulate many aspects of cell identity, function, and survival in multicellular animals. Genes encoding five TGF-β family members are present in the genome of C. elegans. Two of the ligands, DBL-1 and DAF-7, signal through a canonical receptor-Smad signaling pathway; while a third ligand, UNC-129, interacts with a noncanonical signaling pathway. No function has yet been associated with the remaining two ligands. Here we summarize these signaling pathways and their biological functions.

Cited by papers we hold 3

• Vitellogenins - Yolk Gene Function and Regulation in Caenorhabditis elegans · 2019
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• DAF-16/FOXO Transcription Factor in Aging and Longevity · 2017
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• Branched-chain amino acid catabolism is a conserved regulator of physiological ageing · 2015
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