Oxidação Eletroquímica de Anlodipino e Hidroclorotiazida Sobre o Eletrodo de Diamante Dopado com Boro: Potencialidade de Determinação Simultânea em Urina

<p>The present study was undertaken to evaluate the use of boron-doped diamond electrode in the simultaneous voltammetric determination of antihypertensives amlodipine and hydrochlorothiazide in urine sample. Two very well-resolved and reproducible oxidation peaks of amlodipine and hydrochlorothiazide, with separation of 0.360 V, were obtained in Britton-Robinson buffer (pH 5.0). Under the optimum analytical experimental conditions, the square-wave voltammetric method exhibited linear responses for simultaneous determination of amlodipine and hydrochlorothiazide in the concentration range 1.0 × 10⁻⁷ – 2.1 × 10⁻⁶ mol L⁻¹ and 2.0 × 10⁻⁶ – 2.2 × 10⁻⁵ mol L⁻¹, with detection limits of 5.6 × 10⁻⁸ mol L⁻¹ and 1.6 × 10⁻⁷ mol L⁻¹, respectively. The proposed method was applied in the simultaneous determination of amlodipine and hydrochlorothiazide in urine sample<em>.</em></p><p> </p><p>DOI: <a href="http://dx.doi.org/10.17807/orbital.v7i1.673">http://dx.doi.org/10.17807/orbital.v7i1.673</a><em><br /></em></p>

Abstract licence: CC BY-NC-ND

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