Effect of Zolpidem and Enhanced Expiratory Rebreathing Space on Complex Sleep Apnea

Treatment-emergent central sleep apnea has been referred to as 'complex sleep apnea' , where apparently obstructive respiratory events convert to central apneas with application of positive airway pressure.Potential contributing factors may include increased propensity for arousals and positive airway pressure-induced reductions in CO2 which amplifies unstable ventilatory control.Here we demonstrate the dramatic beneficial effects of zolpidem and enhanced expiratory rebreathing space on complex sleep apnea, which helps to elude the mechanism of complex sleep apnea.

Abstract licence: CC BY-NC-ND

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