OppA Escherichia coli mutants have osmodependent resistance to aminoglycoside antibiotics

The oligopeptide permease (OppA) protein was found to be missing in the periplasmic fractions of Escherichia coli kanamycin-resistant mutants selected under high osmotic conditions. The growth behavior of one mutant in media containing kanamycin or the toxic peptide triornithine suggests that OppA and another cell envelope component contribute to the osmolarity-dependent aminoglycoside resistance of E. Coli.<br>Mutantes de Escherichia coli resistentes aos aminoglicosídios por seleção in vitro em meio de cultivo de alta osmolaridade contendo canamicina podem apresentar ausência da proteína periplásmica oligopeptídio permease (OppA). O comportamento desse mutante em presença de canamicina ou do peptídio tóxico triornitina sugere que a proteína OppA e um outro componente do envoltório bacteriano contribuem para a resistência osmodependente em E. coli.

Abstract licence: CC BY

21 more references, whose wording the paper’s licence keeps private.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.