Atypical lymphocytosis in leptospirosis

Dear Editor, Sir, I read the recent report on atypical lymphocytosis in leptospirosis with a great interest 1 .Damasco et al concluded that atypical leukocyte subsets are associated with partial protection during the disease course of leptospirosis" 1 .Some points should be discussed.First, as a nature of retrospective study, there can be many pitfalls.The detection of atypical lymphocytosis is usually problematic if there is no expert medical technologist control the quality of analysis 2 .For sure, the retrospective study cannot control the quality of the laboratory analysis.Second, as Damasco et al mentioned, several diseases can mimic leptospirosis.An important disease that can present atypical lymphocytosis is dengue infection.This infection is also common in the studied setting.The question is whether the diagnosis of leptospirosis is correct.Also, the co-infection between leptospirosis and dengue can be possible 3 and this cannot be ruled out in this work.

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