Toksisitas Akut per Oral Ekstrak Etanol Daun Dewa (Gynura pseudochina (Lour.) DC) terhadap Kondisi Lambung Tikus Jantan dan Betina Galur Wistar

Acute oral toxicity is the adverse effects occurring within a short time of oral administration of a single dose of a substance or multiple doses given within 24 hours through body’s organs. Gastrointestinal tract potentially influenced by toxic materials exposure, shown as gastric erosion and ulcer. This is an acute oral toxicity experimental research, held in Pharmacology laboratorium of Dr. Hasan Sadikin Hospital on July–September 2009. This research aims to determine ethanol extract of Dewa leaf acute toxicity to gaster by measuring ulcer index of ethanol extract of Dewa leaf (Gynura pseudochina (Lour.) DC) in Wistar rats. This research approached with 3R (reduction, refinement and replacement) to overcome negative impact. Ulcer index determined by ulcer’s quantity and diameter due to rats necropsy at 15th day, and histopathology examined. The results are statistically analyzed using Kolmogorov-Smirnov test and then continued with one sample T-test on Statistical Package for the Social Sciences (SPSS) for windows version 13.0, at 95% confidence interval level. Ulcer index significantly different between control group and ethanol extract of Dewa leaf group dose >1.625 g/kgBB (p<0.05). In conclusion, ethanol extract of Dewa leaf on Wistar rats cause gastric ulcer at dose >1.625 g/kgBB.

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