Role of endothelial dysfunction in the formation of cognitive impairment

The aim of the study was to examine of endothelial dysfunction markers in patients with dyscirculatory encephalopathy I–II stages. Material and methods. The study included 30 patients with dyscirculatory encephalopathy I–II stages. All the examinees underwent detection of endothelin-1, desquamated circulating endothelial cells and endothelial NO synthase levels in the blood, reflected endothelial damage. Results of investigation of 21 practically healthy people served as control. Results. Reliable increasing of endothelial dysfunction markers were detected at initial stage of dyscirculatory encephalopathy, aggravated with the progress of disease.

Abstract licence: CC BY

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