Chromosome Duplication in Saccharomyces cerevisiae

Abstract

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic cells, the assembly of the multi-enzyme replisomes that perform replication is divided into stages that occur at distinct phases of the cell cycle. Replicative DNA helicases are loaded around origins of DNA replication exclusively during G1 phase. The loaded helicases are then activated during S phase and associate with the replicative DNA polymerases and other accessory proteins. The function of the resulting replisomes is monitored by checkpoint proteins that protect arrested replisomes and inhibit new initiation when replication is inhibited. The replisome also coordinates nucleosome disassembly, assembly, and the establishment of sister chromatid cohesion. Finally, when two replisomes converge they are disassembled. Studies in Saccharomyces cerevisiae have led the way in our understanding of these processes. Here, we review our increasingly molecular understanding of these events and their regulation.

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197. 197.

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266. 266.
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Cited by papers we hold 7

• RTEL1 and MCM10 overcome topological stress during vertebrate replication termination · 2023
  Not checked
• The mechanism of replication stalling and recovery within repetitive DNA · 2022
  Not checked
• Cryo-EM structures reveal that RFC recognizes both the 3′- and 5′-DNA ends to load PCNA onto gaps for DNA repair · 2022
  Not checked
• Ctf4 organizes sister replisomes and Pol α into a replication factory · 2019
  Not checked
• In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast · 2019
  Not checked
• Transcription-mediated replication hindrance: a major driver of genome instability · 2019
  No notice
• Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome · 2018
  No notice

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