Cell-Type-Selective Effects of Intramembrane Cavitation as a Unifying Theoretical Framework for Ultrasonic Neuromodulation

Abstract

Diverse translational and research applications could benefit from the noninvasive ability to reversibly modulate (excite or suppress) CNS activity using ultrasound pulses, however, without clarifying the underlying mechanism, advanced design-based ultrasonic neuromodulation remains elusive. Recently, intramembrane cavitation within the bilayer membrane was proposed to underlie both the biomechanics and the biophysics of acoustic bio-effects, potentially explaining cortical stimulation results through a neuronal intramembrane cavitation excitation (NICE) model. Here, NICE theory is shown to provide a detailed predictive explanation for the ability of ultrasonic (US) pulses to also suppress neural circuits through cell-type-selective mechanisms: according to the predicted mechanism T-type calcium channels boost charge accumulation between short US pulses selectively in low threshold spiking interneurons, promoting net cortical network inhibition. The theoretical results fit and clarify a wide array of earlier empirical observations in both the cortex and thalamus regarding the dependence of ultrasonic neuromodulation outcomes (excitation-suppression) on stimulation and network parameters. These results further support a unifying hypothesis for ultrasonic neuromodulation, highlighting the potential of advanced waveform design for obtaining cell-type-selective network control.

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Cited by papers we hold 6

• Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification · 2022
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• Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation · 2021
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• Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior · 2020
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• A retrospective qualitative report of symptoms and safety from transcranial focused ultrasound for neuromodulation in humans · 2020
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• Transcranial focused ultrasound neuromodulation of the human primary motor cortex · 2018
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• Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study · 2018
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