Experimental Studies of the Effect of Cyclic Mitoguazone Analogues on Antineoplastic Activity of Methotrexate
Graczyk Julita, Guzowski Grzegorz, Kręźel Izabella
Pteridines · 1998
doi:10.1515/pteridines.1998.9.4.217 (opens in a new tab)
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Abstract
Summary In the presented study we tested the effect of the bi- and monocyclic analogues of mitoguazone on neoplastic activity of methotrexate in the model of L1210 leukemia in mice. We have demonstrated that combined therapy involving administration of methotrexate with 2-oxo-propanal bis (4,5,6,7 -tetrahydroIH- l,3-diazepin-2-yl)methylhydrazone dihydroiodide (aM 7) at different doses is more effective than methotrexate monotherapy in mice inoculated with L1210 leukemia.
Abstract licence: CC BY-NC-ND
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