The Characterization of Microgranules Produced by Tumbling Fluidized Bed Granulator with Opposed Pulsed Jet Assembly [Translated]†

A new granulation method by a tumbling fluidized bed granulator equipped with opposed pulsed air-jet assembly applied to produce the microgranules having the size distribution in less than 100μm region was investigated. Powdered remedy material, consisting of diclofenac sodium as the main component was microgranulated by the granulator to investigate the effects of the pulsed air-jet on the microgranule properties, and also discuss its growth model. It was confirmed that the microgranules produced by the new method have not only the smaller granule size but the remarkably larger surface area, better solubility and higher compressibility compared with those of the granules made by conventional tumbling fluidized bed granulation. The microgranule growth mechanism was characterized by the following three steps. The first step was the formation process of smaller granules by the agglomeration of feed particles. The smaller granule size depended on the spray mist size. The next step was the successive coating process of the smaller granules. The final was the coalescence of the smaller granules into final microgranules.† This report was originally printed in J. Soc. Powder Technology, Japan. 35(4), 256-264 (1998) in Japanese, before being translated into English by KONA Editorial Committee with the permission of the editorial committee of the Soc. Powder Technology, Japan.

Abstract licence: CC BY

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