Glomerular Filtration Rate and Interleukin-8 Level in Patients with Graves' Disease

In patients with various diseases with kidney’s involvement, there was a significant increase of IL-8 urine concentration. In chronic pyelonephritis increase of urine IL-8 have been suggested as an indicator of active renal fibrogenesis. Thyroid hormones affect the kidneys through various mechanisms. The most exact indicator of renal function now is the glomerular filtration rate (GRF). Aim. To study the GFR and IL-8 levels in patients with Graves' disease. Results. The study included 95 patients with Graves' disease in the decompensated thyrotoxicosis stage. GFR above 120 ml/min occurred in 37.9% of patients; 90-120 ml/min - in 40%; below 90 ml/min - in 22.1%. Reduction GFR below 60 ml/min weren’t observed. There is a direct correlation between GFR and triiodothyronine (T3) level (r s = 0.45; p = 0.001), the inverse correlation between GFR and IL-8 level (r s = -0.53; p = 0.037). Conclusion. In patients with Graves' disease detected correlation between T3 level and GFR increase. While GFR reduced it was recorded the IL-8 elevation in serum.

Abstract licence: CC BY-NC-ND

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.