Covert pathogenesis: Transient exposures to microbes as triggers of disease.

Our understanding of microbial pathogenesis is founded largely on the assumption that the microbe responsible for causing a disease is the one that is abundantly present at the time and site of disease symptoms.This situation can be compared to the scenario in which a criminal is caught red-handed at the scene of the crime.In this article, we discuss an alternative scenario-"covert pathogenesis"-in which a microbe acts more like a covert operative, sneaking in undetected or unrecognized to trigger disease onset, escaping before the damage is noticed.Here, we will further define "covert pathogenesis," describe an example of this phenomenon discovered in the urinary tract, highlight other scenarios or diseases that could be impacted by this paradigm, and discuss implications for diagnosis and treatment.

Abstract licence: CC BY

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