Association between vitamin D deficiency and allergic symptom in pregnant women.

<h4>Background</h4>Vitamin D has been reported to affect both innate, and acquired immunity with immune cells such as dendritic cells having the vitamin D receptors. The co-occurrence of the high prevalence of allergic diseases and vitamin D deficiency globally documented in recent decades, has prompted a hypothesis on whether there is a reasonable association between them.<h4>Objective</h4>To investigate the association between serum vitamin D deficiency and allergic symptoms.<h4>Methods</h4>Historical cohort. On a cohort study for the association between desert dust exposure and allergic symptoms in 3,327 pregnant women during spring and fall in 2011-2013 in Japan conducted as an adjunct study to the Japan Environment and Children's Study, we promptly acquired subjects' daily allergic symptom scores by sending a web-based questionnaire to each participant on some days. Of the 29,434 answers provided by 3,327 participating pregnant women, we extracted 13,356 answers from 1,475 pregnant women that were answered within a 3-month period after blood samplings. And we measured 25(OH)D levels on those samples to investigate the association between their vitamin D deficiency (serum 25(OH)D < 20ng/mL) and the occurrence of any allergic symptom (allergic symptom score> 0) within 3 months.<h4>Results</h4>Serum 25(OH)D was less than 20ng/mL in 1,233 of 1,745 samples (70.7%). The adjusted odds ratio (aOR) for occurrence of any allergic symptom in deficient cases compared with non-deficient cases was 1.33 (95% CI: 1.07-1.64, p = 0.01). Further, vitamin D deficiency significantly enhanced the risk increase at desert dust events and at pollen exposure (p-values for interaction <0.1).<h4>Conclusion</h4>We confirmed the association between serum vitamin D deficiency and allergic symptoms in Japanese pregnant women.

Abstract licence: CC BY

1. 3.

   Rationale and study design of the Japan environment and children’s study (JECS) · 2014

2. 5.

   Impact of vitamin D on immune function: lessons learned from genome-wide analysis · 2014

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