Minimal 2'-O-methyl phosphorothioate linkage modification pattern of synthetic guide RNAs for increased stability and efficient CRISPR-Cas9 gene editing avoiding cellular toxicity.
Megan Basila, Melissa L Kelley, Anja van Brabant Smith
PLoS ONE · 2017
doi:10.1371/journal.pone.0188593 (opens in a new tab)
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