The Panhandle formed by influenza A and C virus NS non-coding regions determines NS segment expression.
Bernadette Crescenzo-Chaigne, Cyril Barbezange, Sylvie van der Werf
PLoS ONE · 2013
doi:10.1371/journal.pone.0081550 (opens in a new tab)
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Abstract
Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover, the transcription level of the modified segment seemed to be directly affected by the distal panhandle strength.
Abstract licence: CC BY
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