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Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.
Lynn Burchell, Viduth K Chaugule, Helen Walden
PLoS ONE · 2012
doi:10.1371/journal.pone.0034748
Cited by papers we hold 3
- AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner · 2020No notice
- Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity · 2014No notice
- Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65 · 2014No notice
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