Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner.
Pedro Brites, Monica M Sousa
PLoS Biology · 2022
doi:10.1371/journal.pbio.3001706 (opens in a new tab)
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Abstract
In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder.
Abstract licence: CC BY
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