Insights into how calcium forms plaques in arteries pave the way for new treatments for heart disease.
Janelle Weaver
PLoS Biology · 2013
doi:10.1371/journal.pbio.1001533 (opens in a new tab)
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Abstract
Selected PLOS Biology research articles are accompanied by a synopsis written for a general audience to provide non-experts with insight into the significance of the published work.Illustration of calcifying progenitor cells and their proposed roles in atherosclerotic vascular calcification (VC).Sca-1+/PDGFRa-progenitor cells differentiate into osteoblasts/osteoclasts bi-directionally.PPARc activation can shift the direction of Sca-1+/PDGFRa-progenitor cells toward osteoclasts.
Abstract licence: CC BY
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