Severe Complication of Thiopurine Treatment in a Young Woman with Crohn’s Disease
Michiel PJ Voet, TGA Calon, MMC Hendriks and 1 more
European Journal of Case Reports in Internal Medicine · 2021
doi:10.12890/2021_002350 (opens in a new tab)
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Abstract
Case Description: TA 28-year old woman receiving thiopurine treatment for Crohn’s disease presented with a systemic primo cytomegalovirus (CMV) infection affecting the gut (colitis), liver (hepatitis), lungs (pneumonitis) and eyes (retinitis). Secondary to this systemic infection, she developed splenomegaly, pancytopenia and lymphadenopathy. Anti-viral treatment resulted in complete resolution of clinical, biochemical and radiological abnormalities within 6 weeks. Conclusion: Early recognition is crucial since CMV infection in a patient receiving thiopurine treatment may result in serious complications.
Abstract licence: CC BY-NC-ND
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