Human Exposure to Endocrine-Disrupting Chemicals and Prenatal Risk Factors for Cryptorchidism and Hypospadias: A Nested Case–Control Study

Abstract

Background Exposure to xenoestrogens during pregnancy may disturb the development and function of male sexual organs. Objective In this study we aimed to determine whether the combined effect of environmental estrogens measured as total effective xenoestrogen burden (TEXB) is a risk factor for male urogenital malformations. Methods In a case–control study, nested in a mother–child cohort (n = 702) established at Granada University Hospital, we compared 50 newborns with diagnosis of cryptorchidism and/or hypospadias with 114 boys without malformations matched by gestational age, date of birth, and parity. Controls did not differ from the total cohort in confounding variables. TEXB and levels of 16 organochlorine pesticides were measured in placenta tissues. Characteristics of parents, pregnancy, and birth were gathered by questionnaire. We used conditional and unconditional regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results TEXB from organohalogenated compounds was detectable in 72% and 54% of case and control placentas, respectively. Compared with controls, cases had an OR for detectable versus non-detectable TEXB of 2.82 (95% CI, 1.10–7.24). More pesticides were detected in cases than in controls (9.34 ± 3.19 vs. 6.97 ± 3.93). ORs for cases with detectable levels of pesticides, after adjusting for potential confounders in the conditional regression analysis, were o,p′-DDT (OR = 2.25; 95% CI, 1.03–4.89), p,p′-DDT (OR = 2.63; 95% CI, 1.21–5.72), lindane (OR = 3.38; 95% CI, 1.36–8.38), mirex (OR = 2.85; 95% CI, 1.22–6.66), and endosulfan alpha (OR = 2.19; 95% CI, 0.99–4.82). Engagement of mothers in agriculture (OR = 3.47; 95% CI, 1.33–9.03), fathers’ occupational exposure to xenoestrogens (OR = 2.98; 95% CI, 1.11–8.01), and history of previous stillbirths (OR = 4.20; 95% CI, 1.11–16.66) were also associated with risk of malformations. Conclusions We found an increased risk for male urogenital malformations related to the combined effect of environmental estrogens in placenta.

References 52

1. 1.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1289/ehp.00108463

2. 2.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

3. 3.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1289/ehp.02110743

4. 4.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

5. 5.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1111/j.1365-2605.2004.00473.x

6. 6.
   Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. · 2003

   No notice
7. 7.
   In utero pesticide exposure, maternal paraoxonase activity, and head circumference. · 2004

   No notice
8. 8.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1097/00001648-200203000-00015

9. 9.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1210/jc.2005-0302

10. 10.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0140-6736(04)15998-9

11. 11.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.envres.2003.10.001

12. 12.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.chemosphere.2005.07.024

13. 13.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0140-6736(04)16029-7

14. 14.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1093/bmb/ldg024

15. 15.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0140-6736(98)01352-x

16. 16.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1111/j.1365-2605.2005.00631.x

17. 17.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.tox.2003.10.009

18. 18.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1007/s00216-004-2558-5

19. 19.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

20. 20.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1093/oxfordjournals.aje.a009729

21. 21.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1289/ehp.104-1469503

22. 22.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1055/s-2008-1072381

23. 23.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0378-4274(99)00037-5

24. 24.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1023/b:caco.0000036167.51236.86

25. 25.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

26. 26.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1590/s0102-311x2002000200008

27. 27.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1097/00001648-199709000-00011

28. 28.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1093/aje/155.4.313

29. 29.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.placenta.2006.09.009

30. 30.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1002/bdra.10149

31. 31.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1080/08035259950168144

32. 32.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0378-4347(01)00212-2

33. 33.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1097/00001648-200103000-00003

34. 34.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1191/074823399678846682

35. 35.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1289/ehp.99107297

36. 36.
    Maternal and Paternal Risk Factors for Cryptorchidism and Hypospadias: A Case–Control Study in Newborn Boys · 2004

    No notice
37. 37.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1093/humrep/deh887

38. 38.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.5271/sjweh.1789

39. 39.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0213-9111(01)71593-2

40. 40.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1136/adc.39.208.605

41. 41.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.placenta.2004.10.001

42. 42.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1021/es0101227

43. 43.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1093/humrep/16.5.972

44. 44.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1289/ehp.97105s3647

45. 45.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1289/ehp.95103s7113

46. 46.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1093/humupd/7.3.282

47. 47.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1093/annhyg/mef053

48. 48.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/j.reprotox.2004.12.015

49. 49.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1136/oem.60.8.543

50. 50.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1289/ehp.98106793

51. 51.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

52. 52.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

Cited by papers we hold 2

• Combined Toxic Exposures and Human Health: Biomarkers of Exposure and Effect · 2011
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• The Pine River Statement: Human Health Consequences of DDT Use · 2009
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