Potential Role of Ultrafine Particles in Associations between Airborne Particle Mass and Cardiovascular Health

Abstract

Numerous epidemiologic time-series studies have shown generally consistent associations of cardiovascular hospital admissions and mortality with outdoor air pollution, particularly mass concentrations of particulate matter (PM) ≤2.5 or ≤10 μm in diameter (PM2.5, PM10). Panel studies with repeated measures have supported the time-series results showing associations between PM and risk of cardiac ischemia and arrhythmias, increased blood pressure, decreased heart rate variability, and increased circulating markers of inflammation and thrombosis. The causal components driving the PM associations remain to be identified. Epidemiologic data using pollutant gases and particle characteristics such as particle number concentration and elemental carbon have provided indirect evidence that products of fossil fuel combustion are important. Ultrafine particles < 0.1 μm (UFPs) dominate particle number concentrations and surface area and are therefore capable of carrying large concentrations of adsorbed or condensed toxic air pollutants. It is likely that redox-active components in UFPs from fossil fuel combustion reach cardiovascular target sites. High UFP exposures may lead to systemic inflammation through oxidative stress responses to reactive oxygen species and thereby promote the progression of atherosclerosis and precipitate acute cardiovascular responses ranging from increased blood pressure to myocardial infarction. The next steps in epidemiologic research are to identify more clearly the putative PM casual components and size fractions linked to their sources. To advance this, we discuss in a companion article Sioutas C, Delfino RJ, Singh M. 2005. Environ Health Perspect 113:947–955) the need for and methods of UFP exposure assessment.

References 173

1. 1.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

2. 2.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

3. 3.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

4. 4.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

5. 5.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

6. 6.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

7. 7.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

8. 8.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

9. 9.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

10. 10.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

11. 11.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

12. 12.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

13. 13.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

14. 14.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

15. 15.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

16. 16.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

17. 17.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

18. 18.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

19. 19.
    Temperature, air pollution, and hospitalization for cardiovascular diseases among elderly people in Denver. · 2003

    No notice
20. 20.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

21. 21.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

22. 22.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

23. 23.
    Air pollution and blood markers of cardiovascular risk. · 2001

    No notice
24. 24.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

25. 25.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

26. 26.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

27. 27.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

28. 28.
    Gaseous pollutants in particulate matter epidemiology: confounders or surrogates? · 2001

    No notice
29. 29.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

30. 30.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

31. 31.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

32. 32.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

33. 33.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

34. 34.
    Epidemiologic evidence of cardiovascular effects of particulate air pollution. · 2001

    No notice
35. 35.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

36. 36.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

37. 37.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

38. 38.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

39. 39.
    Ultrafine particle deposition in subjects with asthma. · 2004

    No notice
40. 40.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

41. 41.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

42. 42.
    Effects of particulate air pollution on blood pressure and heart rate in subjects with cardiovascular disease: a multicenter approach. · 2004

    No notice
43. 43.
    Ambient Air Pollution and Atherosclerosis in Los Angeles · 2004

    No notice
44. 44.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

45. 45.
    Personal PM2.5 exposure and markers of oxidative stress in blood. · 2003

    No notice
46. 46.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

47. 47.
    Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. · 2004

    No notice
48. 48.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

49. 49.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

50. 50.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

51. 51.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

52. 52.
    Ambient particle inhalation and the cardiovascular system: potential mechanisms. · 2001

    No notice
53. 53.
    Air pollution and hospital admissions for ischemic heart disease in persons with congestive heart failure or arrhythmia. · 2002

    No notice
54. 54.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

55. 55.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

56. 56.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

57. 57.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

58. 58.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

59. 59.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

60. 60.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

61. 61.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

62. 62.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

63. 63.
    Exposure Assessment for Atmospheric Ultrafine Particles (UFPs) and Implications in Epidemiologic Research · 2005

    No notice
64. 64.
    Airborne particles are a risk factor for hospital admissions for heart and lung disease. · 2000

    No notice
65. 65.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

66. 66.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

67. 67.
    Are there sensitive subgroups for the effects of airborne particles? · 2000

    No notice
68. 68.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

69. 69.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

70. 70.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

71. 71.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

72. 72.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

73. 73.
    The temporal pattern of respiratory and heart disease mortality in response to air pollution. · 2003

    No notice
74. 74.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

75. 75.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

76. 76.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

77. 77.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

78. 78.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

79. 79.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

80. 80.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

81. 81.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

82. 82.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

83. 83.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

84. 84.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

85. 85.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

86. 86.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

87. 87.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

88. 88.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

89. 89.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

90. 90.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

91. 91.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

92. 92.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

93. 93.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

94. 94.
    Air pollution and daily hospital admissions in metropolitan Los Angeles. · 2000

    No notice
95. 95.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

96. 96.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

97. 97.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

98. 98.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

99. 99.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

100. 100.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

101. 101.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

102. 102.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

103. 103.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

104. 104.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

105. 105.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

106. 106.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

107. 107.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

108. 108.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

109. 109.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

110. 110.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

111. 111.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

112. 112.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

113. 113.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

114. 114.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

115. 115.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

116. 116.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

117. 117.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

118. 118.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

119. 119.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

120. 120.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

121. 121.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

122. 122.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

123. 123.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

124. 124.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

125. 125.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

126. 126.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

127. 127.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

128. 128.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

129. 129.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

130. 130.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

131. 131.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

132. 132.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

133. 133.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

134. 134.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

135. 135.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

136. 136.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

137. 137.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

138. 138.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

139. 139.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

140. 140.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

141. 141.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

142. 142.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

143. 143.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

144. 144.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

145. 145.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

146. 146.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

147. 147.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

148. 148.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

149. 149.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

150. 150.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

151. 151.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

152. 152.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

153. 153.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

154. 154.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

155. 155.
     Association of fine particulate matter from different sources with daily mortality in six U.S. cities. · 2000

     No notice
156. 156.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

157. 157.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

158. 158.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

159. 159.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

160. 160.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

161. 161.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

162. 162.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

163. 163.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

164. 164.
     Air conditioning and source-specific particles as modifiers of the effect of PM(10) on hospital admissions for heart and lung disease. · 2002

     No notice
165. 165.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

166. 166.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

167. 167.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

168. 168.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

169. 169.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

170. 170.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

171. 171.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

172. 172.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

173. 173.

     This reference’s wording can’t be shown under the paper’s licence.

     Not in our library

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