Maternal stress modulates the effects of developmental lead exposure.

Abstract

Lead exposure is higher among children with low socioeconomic status (SES) compared with other children in the United States. Low SES itself is a known risk factor for various diseases and dysfunctions, effects that have been ascribed to chronic stress and associated elevation of glucocorticoids. Chronically elevated glucocorticoids and Pb provoke similar behavioral changes, and both can act on mesocorticolimbic systems of the brain. In this study we examined the hypothesis that these co-occurring risk factors, Pb and environmental stress, would interact and modulate each others' effects. Using a rodent model, we focused on the specific contributions of maternal stress (restraint) and maternal Pb exposure (150 ppm in drinking water) on corticosterone levels of offspring, as well as on neurotransmitter changes and a behavioral baseline (fixed-interval schedule-controlled performance) with known sensitivities to Pb. We observed interactions of Pb and stress that differed in relation to outcome measure and sex. In addition, potentiated effects (effects of Pb plus stress but showing no changes produced by either alone) were observed more frequently in females. Importantly, Pb alone (in males) and Pb plus stress (in females) permanently elevated corticosterone levels in offspring; even short-term Pb exposure to dams could cause this effect. Such increases could suggest a potential new mechanism by which Pb exposure could directly or indirectly enhance susceptibility to diseases and dysfunctions and induce cognitive deficits. Moreover, the interactive effects of Pb and stress, and particularly the potentiated effects of Pb plus stress, raise questions about whether current risk assessment strategies sufficiently consider the potential for modulation of toxicity that can accrue from intercurrent risk factors.

References 85

1. 1.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1080/15287398009529916

2. 2.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1016/0091-3057(94)90433-2

3. 3.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1097/00006842-199505000-00003

4. 4.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1159/000073705

5. 5.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1046/j.1460-9568.2000.00996.x

6. 6.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1080/00039896.1994.9937461

7. 7.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1056/nejm198704233161701

8. 8.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1016/0892-0362(88)90084-0

9. 9.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1002/syn.10229

10. 10.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1146/annurev.psych.53.100901.135233

11. 11.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1097/00006842-199207000-00002

12. 12.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1176/ajp.144.9.1123

13. 13.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1056/nejmoa022848

14. 14.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0031-9384(03)00096-9

15. 15.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

16. 16.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1046/j.1471-4159.1997.68052012.x

17. 17.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

18. 18.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0006-8993(97)00591-x

19. 19.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

20. 20.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/0006-8993(92)90180-h

21. 21.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/0041-008x(83)90021-2

22. 22.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

23. 23.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/0041-008x(85)90292-3

24. 24.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0161-813x(02)00059-1

25. 25.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1080/15287399009531412

26. 26.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0378-4274(01)00336-8

27. 27.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/0892-0362(91)90012-l

28. 28.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1523/jneurosci.13-09-03839.1993

29. 29.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1007/bf00789069

30. 30.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1037/h0035718

31. 31.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1161/01.cir.54.6.987

32. 32.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

33. 33.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0031-9384(02)00645-5

34. 34.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1023/a:1022075324164

35. 35.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1007/s002130000650

36. 36.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0083-6729(03)01006-9

37. 37.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/0006-8993(95)00430-x

38. 38.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1001/archpsyc.1982.04290010013003

39. 39.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/0301-0082(94)90014-0

40. 40.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

Cited by papers we hold 5

• Lead Exposure Induces Weight Gain in Adult Rats, Accompanied by DNA Hypermethylation. · 2017
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• Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement · 2016
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• Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution: Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in Male Mice · 2014
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• A Framework for Examining Social Stress and Susceptibility to Air Pollution in Respiratory Health · 2009
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• Low-Level Human Equivalent Gestational Lead Exposure Produces Sex-Specific Motor and Coordination Abnormalities and Late-Onset Obesity in Year-Old Mice · 2007
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