Disposition of orally administered 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A) in pregnant rats and the placental transfer to fetuses.

Abstract

We studied the disposition of bisphenol A (BPA) in pregnant female F344/DuCrj(Fischer) rats and its placental transfer to fetuses after a single oral administration of 1 g/kg BPA dissolved in propylene glycol. BPA in maternal blood, liver, and kidney reached maximal concentrations (14.7, 171, and 36 microg/g) 20 min after the administration and gradually decreased. The levels were 2-5% of the maximum 6 hr after the administration. The maximal concentration of BPA in fetuses (9 microg/g) was also attained 20 min after the administration. BPA levels then gradually reduced in a similar manner to maternal blood. These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA.

References 28

1. 1.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1093/toxsci/50.1.36

2. 2.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1006/rtph.1999.1340

3. 3.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1007/bf02220922

4. 4.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1080/15287397609529360

5. 5.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1210/jcem-50-5-811

6. 6.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1038/44517

7. 7.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1093/toxsci/49.2.172

8. 8.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1016/s0041-008x(66)80001-7

9. 9.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.1080/00139307509435815

10. 10.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1006/faat.1995.1109

11. 11.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1002/tera.1420300307

12. 12.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1080/15287397709529453

13. 13.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

14. 14.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/0272-0590(87)90142-4

15. 15.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/0009-2797(94)03347-1

16. 16.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1289/ehp.9710570

17. 17.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1006/faat.1995.1159

18. 18.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1006/faat.1997.2343

19. 19.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1006/toxs.1998.2518

20. 20.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/s0278-6915(99)00105-2

21. 21.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

22. 22.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1080/004982598239731

23. 23.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1210/endo.139.6.6027

24. 24.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1111/j.1476-5381.1988.tb11488.x

25. 25.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1007/bf01062109

26. 26.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1016/0278-6915(84)90201-1

27. 27.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1006/taap.1999.8673

28. 28.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library10.1177/074823379801400115

Cited by papers we hold 9

• Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction · 2020
  No notice
• MicroRNAs as Potential Signatures of Environmental Exposure or Effect: A Systematic Review · 2015
  No notice
• Perinatally Administered Bisphenol A as a Potential Mammary Gland Carcinogen in Rats · 2013
  No notice
• Environmental Chemicals in Pregnant Women in the United States: NHANES 2003–2004 · 2011
  No notice
• Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan · 2011
  No notice
• Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A · 2010
  No notice
• Does Rapid Metabolism Ensure Negligible Risk from Bisphenol A? · 2009
  No notice
• Perinatal Exposure to Bisphenol A Alters Early Adipogenesis in the Rat · 2009
  No notice
• Prenatal Bisphenol A Exposure Induces Preneoplastic Lesions in the Mammary Gland in Wistar Rats · 2006
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.