Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]
Wim E. Crusio, Esha Dhawan, Elissa J. Chesler and 1 more
F1000Research · 2016
doi:10.12688/f1000research.9484.1 (opens in a new tab)
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Abstract
In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are Syt9 and Ppfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli.
Abstract licence: CC BY
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