Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry
B. Kalderon, V. Sheena, S. Shachrur and 2 more
Journal of Lipid Research · 2002
doi:10.1194/jlr.m200060-jlr200 (opens in a new tab)
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Abstract
The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition of liver fatty acyl-CoAs was found to reflect the composition of dietary fat. Treatment with hypolipidemic carboxylates resulted in liver dominant abundance of their respective acyl-CoAs accompanied by an increase in liver fatty acyl-CoAs.Cellular effects exerted by dietary fatty acids and/or xenobiotic carboxylic drugs may be transduced in vivo by their respective acyl-CoAs.
Abstract licence: CC BY-NC-ND
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