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The mechanism of ferroptosis and its related diseases

Shijian Feng, Dan Tang, Yichang Wang and 14 more

Molecular Biomedicine · 2023 · Review · CC BY

Abstract

Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological and pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, and traumatic tissue injuries. By unraveling the intricate underpinnings of the molecular machinery, pivotal contributors, intricate signaling conduits, and regulatory networks governing ferroptosis, researchers aim to bridge the gap between the intricacies of this unique mode of cellular death and its multifaceted implications for health and disease. In light of the rapidly advancing landscape of ferroptosis research, we present a comprehensive review aiming at the extensive implications of ferroptosis in the origins and progress of human diseases. This review concludes with a careful analysis of potential treatment approaches carefully designed to either inhibit or promote ferroptosis. Additionally, we have succinctly summarized the potential therapeutic targets and compounds that hold promise in targeting ferroptosis within various diseases. This pivotal facet underscores the burgeoning possibilities for manipulating ferroptosis as a therapeutic strategy. In summary, this review enriched the insights of both investigators and practitioners, while fostering an elevated comprehension of ferroptosis and its latent translational utilities. By revealing the basic processes and investigating treatment possibilities, this review provides a crucial resource for scientists and medical practitioners, aiding in a deep understanding of ferroptosis and its effects in various disease situations.

References 861

1.
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death · 2021
No notice
2.
Das S, Shukla N, Singh SS, Kushwaha S, Shrivastava R. Mechanism of interaction between autophagy and apoptosis in cancer. Apoptosis. 2021;26(9–10):512-533.
Not in our library10.1007/s10495-021-01687-9
3.
Raj S, Jaiswal SK, DePamphilis ML. Cell death and the p53 enigma during mammalian embryonic development. Stem Cells. 2022;40(3):227-238.
Not in our library10.1093/stmcls/sxac003
4.
Kist M, Vucic D. Cell death pathways: intricate connections and disease implications. EMBO J. 2021;40(5):e106700.
Not in our library10.15252/embj.2020106700
5.
Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell. 2003;3(3):285-296.
Not in our library10.1016/s1535-6108(03)00050-3
6.
Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008;15(3):234-245.
Not in our library10.1016/j.chembiol.2008.02.010
7.
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060-1072.
Not in our library10.1016/j.cell.2012.03.042
8.
Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520(7545):57-62.
Not in our library10.1038/nature14344
9.
Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266-282.
Not in our library10.1038/s41580-020-00324-8
10.
Ferroptosis: mechanisms and links with diseases · 2021
No notice
11.
Stockwell SJDaBR. The hallmarks of ferroptosis. Annu Rev Cancer Biol. 2019; 2019. 3:35–54. doi:10.1146/annurev-.
Not in our library10.1146/annurev-cancerbio-030518-055844
12.
Ferroptosis, a new form of cell death: opportunities and challenges in cancer · 2019
No notice
13.
Feng H, Schorpp K, Jin J, Yozwiak CE, Hoffstrom BG, Decker AM, et al. Transferrin receptor is a specific ferroptosis marker. Cell Rep. 2020;30(10):3411-23 e7.
Not in our library10.1016/j.celrep.2020.02.049
14.
Schiavi A, Salveridou E, Brinkmann V, Shaik A, Menzel R, Kalyanasundaram S, et al. Mitochondria hormesis delays aging and associated diseases in Caenorhabditis elegans impacting on key ferroptosis players. iScience. 2023;26(4):106448.
Not in our library10.1016/j.isci.2023.106448
15.
Liao P, Wang W, Wang W, Kryczek I, Li X, Bian Y, et al. CD8(+) T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 2022;40(4):365-78.e6.
Not in our library10.1016/j.ccell.2022.02.003
16.
Muller S, Sindikubwabo F, Caneque T, Lafon A, Versini A, Lombard B, et al. CD44 regulates epigenetic plasticity by mediating iron endocytosis. Nat Chem. 2020;12(10):929-938.
Not in our library10.1038/s41557-020-0513-5
17.
Wang Y, Zhang M, Bi R, Su Y, Quan F, Lin Y, et al. ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury. Redox Biol. 2022;51:102262.
Not in our library10.1016/j.redox.2022.102262
18.
Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, et al. Lipid peroxidation drives renal cyst growth in vitro through activation of TMEM16A. J Am Soc Nephrol. 2019;30(2):228-242.
Not in our library10.1681/asn.2018010039
19.
Maser RL, Vassmer D, Magenheimer BS, Calvet JP. Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease. J Am Soc Nephrol. 2002;13(4):991-999.
Not in our library10.1681/asn.v134991
20.
Zhou Z, Ye TJ, DeCaro E, Buehler B, Stahl Z, Bonavita G, et al. Intestinal SIRT1 deficiency protects mice from ethanol-induced liver injury by mitigating ferroptosis. Am J Pathol. 2020;190(1):82-92.
Not in our library10.1016/j.ajpath.2019.09.012
21.
Wang J, Zhu Q, Li R, Zhang J, Ye X, Li X. YAP1 protects against septic liver injury via ferroptosis resistance. Cell Biosci. 2022;12(1):163.
Not in our library10.1186/s13578-022-00902-7
22.
Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis · 2019
No notice
23.
Belaidi AA, Gunn AP, Wong BX, Ayton S, Appukuttan AT, Roberts BR, et al. Marked age-related changes in brain iron homeostasis in amyloid protein precursor knockout mice. Neurotherapeutics. 2018;15(4):1055-1062.
Not in our library10.1007/s13311-018-0656-x
24.
Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, et al. Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke. Cell. 2019;177(5):1262-79 e25.
Not in our library10.1016/j.cell.2019.03.032
25.
Oxidative Stress and Ischemia/Reperfusion Injury in Kidney Transplantation: Focus on Ferroptosis, Mitophagy and New Antioxidants · 2022
No notice
26.
Yu X, Ma X, Lyu J, Jiang N, Lu Y, Liao Y, et al. Ferroptosis involved in sevoflurane-aggravated young rats brain injury induced by liver transplantation. NeuroReport. 2022;33(16):705-713.
Not in our library10.1097/wnr.0000000000001836
27.
Fang X, Wang H, Han D, Xie E, Yang X, Wei J, et al. Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A. 2019;116(7):2672-2680.
Not in our library10.1073/pnas.1821022116
28.
Baba Y, Higa JK, Shimada BK, Horiuchi KM, Suhara T, Kobayashi M, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018;314(3):H659-H668.
Not in our library10.1152/ajpheart.00452.2017
29.
Liu Y, Zeng L, Yang Y, Chen C, Wang D, Wang H. Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition. Cell Death Dis. 2020;11(9):756.
Not in our library10.1038/s41419-020-02948-2
30.
Zang J, Cui M, Xiao L, Zhang J, Jing R. Overexpression of ferroptosis-related genes FSP1 and CISD1 is related to prognosis and tumor immune infiltration in gastric cancer. Clin Transl Oncol. 2023. 10.1007/s12094-023-03136-2.
Not in our library10.1007/s12094-023-03136-2
31.
Panda SK, Peng V, Sudan R, Ulezko Antonova A, Di Luccia B, Ohara TE, et al. Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes. Immunity. 2023;56(4):797-812.e4.
Not in our library10.1016/j.immuni.2023.01.023
32.
Yan Q, Zheng W, Jiang Y, Zhou P, Lai Y, Liu C, et al. Transcriptomic reveals the ferroptosis features of host response in a mouse model of Zika virus infection. J Med Virol. 2023;95(1):e28386.
Not in our library10.1002/jmv.28386
33.
Sawicki KT, De Jesus A, Ardehali H. Iron metabolism in cardiovascular disease: physiology, mechanisms, and therapeutic targets. Circ Res. 2023;132(3):379-396.
Not in our library10.1161/circresaha.122.321667
34.
Zeng F, Ye L, Zhou Q, He Y, Zhang Y, Deng G, et al. Inhibiting SCD expression by IGF1R during lorlatinib therapy sensitizes melanoma to ferroptosis. Redox Biol. 2023;61:102653.
Not in our library10.1016/j.redox.2023.102653
35.
Targeted xCT‐mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti‐PD‐1/L1 Response · 2022
No notice
36.
Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, et al. Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. J Clin Invest. 2018;128(8):3341-3355.
Not in our library10.1172/jci99032
37.
The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis · 2022
No notice
38.
Iron Metabolism in Ferroptosis · 2020
No notice
39.
Fang X, Ardehali H, Min J, Wang F. The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease. Nat Rev Cardiol. 2023;20(1):7-23.
Not in our library10.1038/s41569-022-00735-4
40.
ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity · 2022
No notice
41.
Chen X, Kang R, Tang D. Ferroptosis by lipid peroxidation: the tip of the iceberg? Front Cell Dev Biol. 2021;9:646890.
Not in our library10.3389/fcell.2021.646890
42.
Conrad M, Kagan VE, Bayir H, Pagnussat GC, Head B, Traber MG, et al. Regulation of lipid peroxidation and ferroptosis in diverse species. Genes Dev. 2018;32(9–10):602-619.
Not in our library10.1101/gad.314674.118
43.
Lipid Metabolism and Ferroptosis · 2021
No notice
44.
Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci U S A. 2016;113(34):E4966-E4975.
Not in our library10.1073/pnas.1603244113
45.
Kagan VE, Mao G, Qu F, Angeli JPF, Doll S, Croix CS, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017;13(1):81-90.
Not in our library10.1038/nchembio.2238
46.
Yang WS, Stockwell BR. Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol. 2016;26(3):165-176.
Not in our library10.1016/j.tcb.2015.10.014
47.
Oxidative Damage and Antioxidant Defense in Ferroptosis · 2020
No notice
48.
Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases · 2021
No notice
49.
Ferroptosis: molecular mechanisms and health implications · 2020
No notice
50.
Ursini F, Maiorino M. Lipid peroxidation and ferroptosis: The role of GSH and GPx4. Free Radic Biol Med. 2020;152:175-185.
Not in our library10.1016/j.freeradbiomed.2020.02.027
51.
Zhang LL, Tang RJ, Yang YJ. The underlying pathological mechanism of ferroptosis in the development of cardiovascular disease. Front Cardiovasc Med. 2022;9:964034.
Not in our library10.3389/fcvm.2022.964034
52.
GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis · 2021
No notice
53.
Zheng J, Conrad M. The metabolic underpinnings of ferroptosis. Cell Metab. 2020;32(6):920-937.
Not in our library10.1016/j.cmet.2020.10.011
54.
The interaction between ferroptosis and lipid metabolism in cancer · 2020
No notice
55.
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273-285.
Not in our library10.1016/j.cell.2017.09.021
56.
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis · 2019
No notice
57.
Xu Z, Xie Y, Mao Y, Huang J, Mei X, Song J, et al. Ferroptosis-related gene signature predicts the prognosis of skin cutaneous melanoma and response to immunotherapy. Front Genet. 2021;12:758981.
Not in our library10.3389/fgene.2021.758981
58.
Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388(6641):482-488.
Not in our library10.1038/41343
59.
Wang C-Y, Knutson MD. Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice. Hepatology. 2013;58(2):788-798.
Not in our library10.1002/hep.26401
60.
Ems T, St Lucia K, Huecker MR. Biochemistry, iron absorption. 2023.
Not in our library
61.
Zhang DL, Ghosh MC, Ollivierre H, Li Y, Rouault TA. Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress. Blood. 2018;132(19):2078-2087.
Not in our library10.1182/blood-2018-04-842997
62.
Drakesmith H, Nemeth E, Ganz T. Ironing out ferroportin. Cell Metab. 2015;22(5):777-787.
Not in our library10.1016/j.cmet.2015.09.006
63.
Fillebeen C, Charlebois E, Wagner J, Katsarou A, Mui J, Vali H, et al. Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load. Blood. 2019;133(4):344-355.
Not in our library10.1182/blood-2018-05-850404
64.
Yanatori I, Kishi F. DMT1 and iron transport. Free Radic Biol Med. 2019;133:55-63.
Not in our library10.1016/j.freeradbiomed.2018.07.020
65.
Chutvanichkul B, Vattanaviboon P, Mas-Oodi S, Y UP, Wanachiwanawin W. Labile iron pool as a parameter to monitor iron overload and oxidative stress status in β-thalassemic erythrocytes. Cytometry B Clin Cytom. 2018;94(4):631-6.
Not in our library10.1002/cyto.b.21633
66.
Kakhlon O, Cabantchik ZI. The labile iron pool: characterization, measurement, and participation in cellular processes(1). Free Radic Biol Med. 2002;33(8):1037-1046.
Not in our library10.1016/s0891-5849(02)01006-7
67.
Ali MY, Oliva CR, Flor S, Griguer CE. Mitoferrin, cellular and mitochondrial iron homeostasis. Cells. 2022;11(21). 10.3390/cells11213464.
Not in our library10.3390/cells11213464
68.
Kotla NK, Dutta P, Parimi S, Das NK. The role of ferritin in health and disease: recent advances and understandings. Metabolites. 2022;12(7). 10.3390/metabo12070609.
Not in our library10.3390/metabo12070609
69.
Acoba MG, Alpergin ESS, Renuse S, Fernández-Del-Río L, Lu YW, Khalimonchuk O, et al. The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Rep. 2021;34(11):108869.
Not in our library10.1016/j.celrep.2021.108869
70.
Anderson GJ, Frazer DM. Current understanding of iron homeostasis. Am J Clin Nutr. 2017;106(Suppl 6):1559S-S1566.
Not in our library10.3945/ajcn.117.155804
71.
Coffey R, Ganz T. Iron homeostasis: An anthropocentric perspective. J Biol Chem. 2017;292(31):12727-12734.
Not in our library10.1074/jbc.r117.781823
72.
Evstatiev R, Gasche C. Iron sensing and signalling. Gut. 2012;61(6):933-952.
Not in our library10.1136/gut.2010.214312
73.
Double-edge sword roles of iron in driving energy production versus instigating ferroptosis · 2022
No notice
74.
Dixon SJ, Stockwell BR. The role of iron and reactive oxygen species in cell death. Nat Chem Biol. 2014;10(1):9-17.
Not in our library10.1038/nchembio.1416
75.
Doll S, Conrad M. Iron and ferroptosis: a still ill-defined liaison. IUBMB Life. 2017;69(6):423-434.
Not in our library10.1002/iub.1616
76.
Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509(7498):105-109.
Not in our library10.1038/nature13148
77.
Brown CW, Amante JJ, Chhoy P, Elaimy AL, Liu H, Zhu LJ, et al. Prominin2 drives ferroptosis resistance by stimulating iron export. Dev Cell. 2019;51(5):575-86.e4.
Not in our library10.1016/j.devcel.2019.10.007
78.
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis · 2019
No notice
79.
Stadtman ER, Berlett BS. Fenton chemistry. Amino acid oxidation J Biol Chem. 1991;266(26):17201-17211.
Not in our library
80.
Prousek J. Fenton chemistry in biology and medicine. Pure Appl Chem. 2007;79(12):2325-2338.
Not in our library10.1351/pac200779122325
81.
Waldvogel-Abramowski S, Waeber G, Gassner C, Buser A, Frey BM, Favrat B, et al. Physiology of iron metabolism. Transfus Med Hemother. 2014;41(3):213-221.
Not in our library10.1159/000362888
82.
Huang J, Simcox J, Mitchell TC, Jones D, Cox J, Luo B, et al. Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice. FASEB J. 2013;27(7):2845-2854.
Not in our library10.1096/fj.12-216929
83.
Jahng JWS, Alsaadi RM, Palanivel R, Song E, Hipolito VEB, Sung HK, et al. Iron overload inhibits late stage autophagic flux leading to insulin resistance. EMBO Rep. 2019;20(10):e47911.
Not in our library10.15252/embr.201947911
84.
Davis MR, Rendina E, Peterson SK, Lucas EA, Smith BJ, Clarke SL. Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency. Genes Nutr. 2012;7(3):415-425.
Not in our library10.1007/s12263-011-0278-y
85.
Potashnik R, Kozlovsky N, Ben-Ezra S, Rudich A, Bashan N. Regulation of glucose transport and GLUT-1 expression by iron chelators in muscle cells in culture. Am J Physiol. 1995;269(6):E1052-E1058.
Not in our library10.1152/ajpendo.1995.269.6.e1052
86.
Backe MB, Moen IW, Ellervik C, Hansen JB, Mandrup-Poulsen T. Iron regulation of pancreatic beta-cell functions and oxidative stress. Annu Rev Nutr. 2016;36:241-273.
Not in our library10.1146/annurev-nutr-071715-050939
87.
Weis S, Carlos AR, Moita MR, Singh S, Blankenhaus B, Cardoso S, et al. Metabolic adaptation establishes disease tolerance to sepsis. Cell. 2017;169(7):1263-75.e14.
Not in our library10.1016/j.cell.2017.05.031
88.
Hay SM, McArdle HJ, Hayes HE, Stevens VJ, Rees WD. The effect of iron deficiency on the temporal changes in the expression of genes associated with fat metabolism in the pregnant rat. Physiol Rep. 2016;4(21). 10.14814/phy2.12908.
Not in our library10.14814/phy2.12908
89.
Radi R. Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine. Proc Natl Acad Sci U S A. 2018;115(23):5839-5848.
Not in our library10.1073/pnas.1804932115
90.
Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo · 2019
No notice
91.
Sherman AR. Lipogenesis in iron-deficient adult rats. Lipids. 1978;13(7):473-478.
Not in our library10.1007/bf02533616
92.
Myllyharju J. Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol. 2003;22(1):15-24.
Not in our library10.1016/s0945-053x(03)00006-4
93.
Buongiorno D, Straganz GD. Structure and function of atypically coordinated enzymatic mononuclear non-heme-Fe(II) centers. Coord Chem Rev. 2013;257(2):541-563.
Not in our library10.1016/j.ccr.2012.04.028
94.
Yu Q, Tai Y-Y, Tang Y, Zhao J, Negi V, Culley MK, et al. BOLA (BolA Family Member 3) deficiency controls endothelial metabolism and glycine homeostasis in pulmonary hypertension. Circulation. 2019;139(19):2238-2255.
Not in our library10.1161/circulationaha.118.035889
95.
Góger S, Bogáth D, Baráth G, Simaan AJ, Speier G, Kaizer J. Bio-inspired amino acid oxidation by a non-heme iron catalyst. J Inorg Biochem. 2013;123:46-52.
Not in our library10.1016/j.jinorgbio.2013.02.007
96.
Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ, et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 2016;12(8):1425-1428.
Not in our library10.1080/15548627.2016.1187366
97.
Li N, Wang W, Zhou H, Wu Q, Duan M, Liu C, et al. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radic Biol Med. 2020;160:303-318.
Not in our library10.1016/j.freeradbiomed.2020.08.009
98.
Tang M, Huang Z, Luo X, Liu M, Wang L, Qi Z, et al. Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy. Free Radic Biol Med. 2019;134:445-457.
Not in our library10.1016/j.freeradbiomed.2019.01.052
99.
A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese · 2018
No notice
100.
Nigam S, Schewe T. Phospholipase A(2)s and lipid peroxidation. Biochim Biophys Acta. 2000;1488(1–2):167-181.
Not in our library10.1016/s1388-1981(00)00119-0
101.
Muralikrishna Adibhatla R, Hatcher JF. Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia. Free Radic Biol Med. 2006;40(3):376-387.
Not in our library10.1016/j.freeradbiomed.2005.08.044
102.
Negre-Salvayre A, Auge N, Ayala V, Basaga H, Boada J, Brenke R, et al. Pathological aspects of lipid peroxidation. Free Radic Res. 2010;44(10):1125-1171.
Not in our library10.3109/10715762.2010.498478
103.
Niki E. Lipid peroxidation: physiological levels and dual biological effects. Free Radic Biol Med. 2009;47(5):469-484.
Not in our library10.1016/j.freeradbiomed.2009.05.032
104.
H Y, L X, Na P. Free radical lipid peroxidation: mechanisms and analysis. Chem Rev. 2011;111(10). 10.1021/cr200084z.
Not in our library10.1021/cr200084z
105.
Girotti AW. Lipid hydroperoxide generation, turnover, and effector action in biological systems. J Lipid Res. 1998;39(8):1529-1542.
Not in our library10.1016/s0022-2275(20)32182-9
106.
Kanner J, German JB, Kinsella JE. Initiation of lipid peroxidation in biological systems. Crit Rev Food Sci Nutr. 1987;25(4):317-364.
Not in our library10.1080/10408398709527457
107.
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal · 2014
No notice
108.
Bayir H, Dixon SJ, Tyurina YY, Kellum JA, Kagan VE. Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney. Nat Rev Nephrol. 2023;19(5):315-336.
Not in our library10.1038/s41581-023-00689-x
109.
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13(1):91-98.
Not in our library10.1038/nchembio.2239
110.
Yuan ZH, Liu T, Wang H, Xue LX, Wang JJ. Fatty acids metabolism: the bridge between ferroptosis and ionizing radiation. Front Cell Dev Biol. 2021;9:675617.
Not in our library10.3389/fcell.2021.675617
111.
White B. Dietary fatty acids. Am Fam Physician. 2009;80(4):345-350.
Not in our library
112.
Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, et al. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol. 2020;22(2):225-234.
Not in our library10.1038/s41556-020-0461-8
113.
Definition of polyunsaturated fatty acid - NCI Drug Dictionary - NCI. 2011. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/polyunsaturated-fatty-acid.
Not in our library
114.
Bentsen H. Dietary polyunsaturated fatty acids, brain function and mental health. Microb Ecol Health Dis. 2017;28(sup1):1281916.
Not in our library10.1080/16512235.2017.1281916
115.
Wiktorowska-Owczarek A, Berezinska M, Nowak JZ. PUFAs: Structures, metabolism and functions. Adv Clin Exp Med. 2015;24(6):931-941.
Not in our library10.17219/acem/31243
116.
Rouzer CA, Marnett LJ. Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases. Chem Rev. 2003;103(6):2239-2304.
Not in our library10.1021/cr000068x
117.
Xiao M, Zhong H, Xia L, Tao Y, Yin H. Pathophysiology of mitochondrial lipid oxidation: role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria. Free Radic Biol Med. 2017;111:316-327.
Not in our library10.1016/j.freeradbiomed.2017.04.363
118.
Magtanong L, Ko P-J, To M, Cao JY, Forcina GC, Tarangelo A, et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem Biol. 2019;26(3):420-32.e9.
Not in our library10.1016/j.chembiol.2018.11.016
119.
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma · 2022
No notice
120.
Pope LE, Dixon S. The role of monounsaturated fatty acids in ferroptosis. The FASEB Journal. 2022;36(S1). 10.1096/fasebj.2022.36.S1.0R871.
Not in our library
121.
Tanaka A, Yamamoto A, Murota K, Tsujiuchi T, Iwamori M, Fukushima N. Polyunsaturated fatty acids induce ovarian cancer cell death through ROS-dependent MAP kinase activation. Biochem Biophys Res Commun. 2017;493(1):468-473.
Not in our library10.1016/j.bbrc.2017.08.168
122.
Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy · 2012
No notice
123.
Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis · 2021
No notice
124.
Zou Y, Henry WS, Ricq EL, Graham ET, Phadnis VV, Maretich P, et al. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature. 2020;585(7826):603-608.
Not in our library10.1038/s41586-020-2732-8
125.
Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev. 2011;111(10):6130-6185.
Not in our library10.1021/cr200085w
126.
Bourdillon MT, Ford BA, Knulty AT, Gray CN, Zhang M, Ford D, et al. Oxidation of plasmalogen, low-density lipoprotein and RAW 264.7 cells by photoactivatable atomic oxygen precursors. Photochem Photobiol. 2014;90(2):386-93.
Not in our library10.1111/php.12201
127.
Structural and functional roles of ether lipids · 2017
No notice
128.
Perez MA, Magtanong L, Dixon SJ, Watts JL. Dietary lipids induce ferroptosis in caenorhabditiselegans and human cancer cells. Dev Cell. 2020;54(4):447-54 e4.
Not in our library10.1016/j.devcel.2020.06.019
129.
Balgoma D, Hedeland M. Etherglycerophospholipids and ferroptosis: structure, regulation, and location. Trends Endocrinol Metab. 2021;32(12):960-962.
Not in our library10.1016/j.tem.2021.08.005
130.
Liang D, Feng Y, Zandkarimi F, Wang H, Zhang Z, Kim J, et al. Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones. Cell. 2023;186(13):2748-64 e22.
Not in our library10.1016/j.cell.2023.05.003
131.
Hishikawa D, Shindou H, Kobayashi S, Nakanishi H, Taguchi R, Shimizu T. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc Natl Acad Sci U S A. 2008;105(8):2830-2835.
Not in our library10.1073/pnas.0712245105
132.
Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M, et al. Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chem Biol. 2015;10(7):1604-1609.
Not in our library10.1021/acschembio.5b00245
133.
Küch E-M, Vellaramkalayil R, Zhang I, Lehnen D, Brügger B, Sreemmel W, et al. Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol. Biochim Biophys Acta. 2014;1841(2):227-239.
Not in our library10.1016/j.bbalip.2013.10.018
134.
Grube J, Woitok MM, Mohs A, Erschfeld S, Lynen C, Trautwein C, et al. ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression. Cell Death Dis. 2022;13(8):1-13.
Not in our library10.1038/s41419-022-05137-5
135.
Reed A, Ichu T-A, Milosevich N, Melillo B, Schafroth MA, Otsuka Y, et al. LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis. ACS Chem Biol. 2022;17(6):1607-1618.
Not in our library10.1021/acschembio.2c00317
136.
Mbah NE, Lyssiotis CA. Metabolic regulation of ferroptosis in the tumor microenvironment. J Biol Chem. 2022;298(3). 10.1016/j.jbc.2022.101617.
Not in our library10.1016/j.jbc.2022.101617
137.
Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, et al. PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals. Cell. 2017;171(3):628-41.e26.
Not in our library10.1016/j.cell.2017.09.044
138.
Conrad M, Pratt DA. The chemical basis of ferroptosis. Nat Chem Biol. 2019;15(12):1137-1147.
Not in our library10.1038/s41589-019-0408-1
139.
Fenton HJH. LXXIII.—Oxidation of tartaric acid in presence of iron. J Chem Soc. 1894;65(0):899-910.
Not in our library10.1039/ct8946500899
140.
A R, Cm S. Chemistry of phospholipid oxidation. Biochim Biophys Acta. 2012;1818(10). 10.1016/j.bbamem.2012.02.002.
Not in our library10.1016/j.bbamem.2012.02.002
141.
Kuhn H, Saam J, Eibach S, Holzhutter HG, Ivanov I, Walther M. Structural biology of mammalian lipoxygenases: enzymatic consequences of targeted alterations of the protein structure. Biochem Biophys Res Commun. 2005;338(1):93-101.
Not in our library10.1016/j.bbrc.2005.08.238
142.
Xu S, Mueser TC, Marnett LJ, Funk MO. Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis. Structure. 2012;20(9):1490-1497.
Not in our library10.1016/j.str.2012.06.00
143.
Newcomer ME, Brash AR. The structural basis for specificity in lipoxygenase catalysis. Protein Sci. 2015;24(3):298-309.
Not in our library10.1002/pro.2626
144.
Ou Y, Wang S-J, Li D, Chu B, Gu W. Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci U S A. 2016;113(44):E6806-E6812.
Not in our library10.1073/pnas.1607152113
145.
Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A. 2010;107(16):7455-7460.
Not in our library10.1073/pnas.1001006107
146.
Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. Glutaminolysis and transferrin regulate ferroptosis. Mol Cell. 2015;59(2):298-308.
Not in our library10.1016/j.molcel.2015.06.011
147.
Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, et al. The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity. Cell Rep. 2017;20(7):1692-1704.
Not in our library10.1016/j.celrep.2017.07.055
148.
p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells · 2018
Not checked
149.
Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, et al. ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway. Nat Cell Biol. 2019;21(5):579-591.
Not in our library10.1038/s41556-019-0305-6
150.
Zhao J, O'Donnell VB, Balzar S, St Croix CM, Trudeau JB, Wenzel SE. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proc Natl Acad Sci U S A. 2011;108(34):14246-14251.
Not in our library10.1073/pnas.1018075108
151.
Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, et al. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature. 1999;401(6749):173-177.
Not in our library10.1038/43686
152.
Sheng XH, Cui CC, Shan C, Li YZ, Sheng DH, Sun B, et al. O-Phenylenediamine: a privileged pharmacophore of ferrostatins for radical-trapping reactivity in blocking ferroptosis. Org Biomol Chem. 2018;16(21):3952-3960.
Not in our library10.1039/c8ob00546j
153.
Anthonymuthu TS, Tyurina YY, Sun W-Y, Mikulska-Ruminska K, Shrivastava IH, Tyurin VA, et al. Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis. Redox Biol. 2021;38:101744.
Not in our library10.1016/j.redox.2020.101744
154.
NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology · 2021
No notice
155.
Yang W-H, Huang Z, Wu J, Ding C-KC, Murphy SK, Chi J-T. A TAZ-ANGPTL4-NOX2 axis regulates ferroptotic cell death and chemoresistance in epithelial ovarian cancer. Mol Cancer Res. 2020;18(1):79-90.
Not in our library10.1158/1541-7786.mcr-19-0691
156.
Yang W-H, Ding C-KC, Sun T, Rupprecht G, Lin C-C, Hsu D, et al. The hippo pathway effector TAZ regulates ferroptosis in renal cell carcinoma. Cell Rep. 2019;28(10):2501-8.e4.
Not in our library10.1016/j.celrep.2019.07.107
157.
Pharmacological characterization of the seven human NOX isoforms and their inhibitors · 2019
No notice
158.
Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, et al. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nat Chem Biol. 2020;16(3):302-309.
Not in our library10.1038/s41589-020-0472-6
159.
Riddick DS, Ding X, Wolf CR, Porter TD, Pandey AV, Zhang Q-Y, et al. NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology. Drug Metab Dispos. 2013;41(1):12-23.
Not in our library10.1124/dmd.112.048991
160.
Yan B, Ai Y, Sun Q, Ma Y, Cao Y, Wang J, et al. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. Mol Cell. 2021;81(2):355-69.e10.
Not in our library10.1016/j.molcel.2020.11.024
161.
Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009;30(1–2):1-12.
Not in our library10.1016/j.mam.2008.08.006
162.
Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother. 2003;57(3–4):145-155.
Not in our library10.1016/s0753-3322(03)00043-x
163.
Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions · 2012
No notice
164.
Zitka O, Skalickova S, Gumulec J, Masarik M, Adam V, Hubalek J, et al. Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients. Oncol Lett. 2012;4(6):1247-1253.
Not in our library10.3892/ol.2012.931
165.
Angeli JPF, Proneth B, Hammond VJ, Tyurina YY, Tyurin VA, O`Donnell VB et al. Inactivation of the Ferroptosis Regulator Gpx4 Triggers Acute Renal Failure in a Therapeutically Relevant Mechanism. Nat Cell Biol. 2014;Supplement 1(76):S77-S8. 10.1038/ncb3064.
Not in our library10.1038/ncb3064
166.
Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317-331.
Not in our library10.1016/j.cell.2013.12.010
167.
Bannai S, Kitamura E. Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture. J Biol Chem. 1980;255(6):2372-2376.
Not in our library10.1016/s0021-9258(19)85901-x
168.
Kobayashi S, Sato M, Kasakoshi T, Tsutsui T, Sugimoto M, Osaki M, et al. Cystathionine is a novel substrate of cystine/glutamate transporter: IMPLICATIONS FOR IMMUNE FUNCTION*. J Biol Chem. 2015;290(14):8778-8788.
Not in our library10.1074/jbc.m114.625053
169.
Sato H, Tamba M, Ishii T, Bannai S. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins*. J Biol Chem. 1999;274(17):11455-11458.
Not in our library10.1074/jbc.274.17.11455
170.
Ye P, Mimura J, Okada T, Sato H, Liu T, Maruyama A, et al. Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition. Mol Cell Biol. 2014;34(18):3421-3434.
Not in our library10.1128/mcb.00221-14
171.
Jennis M, Kung CP, Basu S, Budina-Kolomets A, Leu JI, Khaku S, et al. An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model. Genes Dev. 2016;30(8):918-930.
Not in our library10.1101/gad.275891.115
172.
Mandal PK, Seiler A, Perisic T, Kölle P, Banjac Canak A, Förster H, et al. System xc− and thioredoxin reductase 1 cooperatively rescue glutathione deficiency*. J Biol Chem. 2010;285(29):22244-22253.
Not in our library10.1074/jbc.m110.121327
173.
Hayano M, Yang WS, Corn CK, Pagano NC, Stockwell BR. Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation. Cell Death Differ. 2016;23(2):270-278.
Not in our library10.1038/cdd.2015.93
174.
Conrad M, Sato H. The oxidative stress-inducible cystine/glutamate antiporter, system xc−: cystine supplier and beyond. Amino Acids. 2012;42(1):231-246.
Not in our library10.1007/s00726-011-0867-5
175.
Lu SC. Glutathione synthesis. Biochim Biophys Acta. 2013;1830(5):3143-3153.
Not in our library10.1016/j.bbagen.2012.09.008
176.
Lu SC. Regulation of glutathione synthesis. Mol Aspects Med. 2009;30(1–2):42-59.
Not in our library10.1016/j.mam.2008.05.005
177.
Cardoso BR, Hare DJ, Bush AI, Roberts BR. Glutathione peroxidase 4: a new player in neurodegeneration? Mol Psychiatry. 2017;22(3):328-335.
Not in our library10.1038/mp.2016.196
178.
Xu C, Sun S, Johnson T, Qi R, Zhang S, Zhang J, et al. The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity. Cell Rep. 2021;35(11):109235.
Not in our library10.1016/j.celrep.2021.109235
179.
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis · 2019
No notice
180.
Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688-692.
Not in our library10.1038/s41586-019-1705-2
181.
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575(7784):693-698.
Not in our library10.1038/s41586-019-1707-0
182.
Gong M, Hay S, Marshall KR, Munro AW, Scrutton NS. DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis. J Biol Chem. 2007;282(41):30331-30340.
Not in our library10.1074/jbc.m703713200
183.
Wu M, Xu L-G, Li X, Zhai Z, Shu H-B. AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol Chem. 2002;277(28):25617-25623.
Not in our library10.1074/jbc.m202285200
184.
Ferroptosis: past, present and future · 2020
No notice
185.
Nyquist SE, Barr R, Morré DJ. Ubiquinone from rat liver Golgi apparatus fractions. Biochim Biophys Acta. 1970;208(3):532-534.
Not in our library10.1016/0304-4165(70)90228-x
186.
Nguyen HP, Yi D, Lin F, Viscarra JA, Tabuchi C, Ngo K, et al. Aifm2, a NADH oxidase, supports robust glycolysis and Is required for cold- and diet-induced thermogenesis. Mol Cell. 2020;77(3):600-17.e4.
Not in our library10.1016/j.molcel.2019.12.002
187.
A non-canonical vitamin K cycle is a potent ferroptosis suppressor · 2022
No notice
188.
Jin DY, Chen X, Liu Y, Williams CM, Pedersen LC, Stafford DW, et al. A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase. Nat Commun. 2023;14(1):828.
Not in our library10.1038/s41467-023-36446-8
189.
A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers · 2022
No notice
190.
Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation · 2022
No notice
191.
Hendricks JM, Doubravsky CE, Wehri E, Li Z, Roberts MA, Deol KK, et al. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem Biol. 2023.
Not in our library10.1016/j.chembiol.2023.04.007
192.
Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008;8(3):237-248.
Not in our library10.1016/j.cmet.2008.07.005
193.
Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, et al. Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Nature. 2019;572(7769):402-406.
Not in our library10.1038/s41586-019-1426-6
194.
Schneider M, Wortmann M, Mandal PK, Arpornchayanon W, Jannasch K, Alves F, et al. Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity. Neoplasia. 2010;12(3):254-263.
Not in our library10.1593/neo.91782
195.
Zhao B, Lei Q-Y, Guan K-L. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol. 2008;20(6):638-646.
Not in our library10.1016/j.ceb.2008.10.001
196.
Pan D. The hippo signaling pathway in development and cancer. Dev Cell. 2010;19(4):491-505.
Not in our library10.1016/j.devcel.2010.09.011
197.
Chovatiya R, Medzhitov R. Stress, inflammation, and defense of homeostasis. Mol Cell. 2014;54(2):281-288.
Not in our library10.1016/j.molcel.2014.03.030
198.
Green DR, Galluzzi L, Kroemer G. Cell biology. Metabolic control of cell death. Science. 2014;345(6203):1250256.
Not in our library10.1126/science.1250256
199.
Hay N. Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? Nat Rev Cancer. 2016;16(10):635-649.
Not in our library10.1038/nrc.2016.77
200.
LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis · 2020
No notice
201.
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis · 2014
No notice
202.
Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction · 2022
No notice
203.
Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375(6586):1254-1261.
Not in our library10.1126/science.abf0529
204.
Zeng F, Nijiati S, Tang L, Ye J, Zhou Z, Chen X. Ferroptosis detection: from approaches to applications. Angew Chem Int Ed Engl. 2023:e202300379. 10.1002/anie.202300379.
Not in our library10.1002/anie.202300379
205.
Characteristics and Biomarkers of Ferroptosis · 2021
No notice
206.
Zeng C, Lin J, Zhang K, Ou H, Shen K, Liu Q, et al. SHARPIN promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/SLC7A11/GPX4 signaling. Cancer Sci. 2022;113(11):3766-3775.
Not in our library10.1111/cas.15531
207.
He C, Wang C, Liu H, Shan B. Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells. BMC Cancer. 2022;22(1):724.
Not in our library10.1186/s12885-022-09825-5
208.
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation · 2022
No notice
209.
Xia Z, Kon N, Gu AP, Tavana O, Gu W. Deciphering the acetylation code of p53 in transcription regulation and tumor suppression. Oncogene. 2022;41(22):3039-3050.
Not in our library10.1038/s41388-022-02331-9
210.
Yang J, Wei X, Hu F, Dong W, Sun L. Development and validation of a novel 3-gene prognostic model for pancreatic adenocarcinoma based on ferroptosis-related genes. Cancer Cell Int. 2022;22(1):21.
Not in our library10.1186/s12935-021-02431-8
211.
Wang D, Tang L, Zhang Y, Ge G, Jiang X, Mo Y, et al. Regulatory pathways and drugs associated with ferroptosis in tumors. Cell Death Dis. 2022;13(6):544.
Not in our library10.1038/s41419-022-04927-1
212.
Leu JI, Murphy ME, George DL. Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53. Proc Natl Acad Sci U S A. 2019;116(17):8390-8396.
Not in our library10.1073/pnas.1821277116
213.
Wang X, Chen Y, Yang X, Cheng L, He Z, Xin Y, et al. Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis. Cell Death Dis. 2022;13(12):1040.
Not in our library10.1038/s41419-022-05462-9
214.
Egolf S, Zou J, Anderson A, Simpson CL, Aubert Y, Prouty S, et al. MLL4 mediates differentiation and tumor suppression through ferroptosis. Sci Adv. 2021;7(50):eabj9141.
Not in our library10.1126/sciadv.abj9141
215.
Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20(10):1181-1192.
Not in our library10.1038/s41556-018-0178-0
216.
Zhang Y, Zhuang L, Gan B. BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression. Mol Cell Oncol. 2019;6(1):1536845.
Not in our library10.1080/23723556.2018.1536845
217.
Zhang Y, Koppula P, Gan B. Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1. Cell Cycle. 2019;18(8):773-783.
Not in our library10.1080/15384101.2019.1597506
218.
Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. 2017;551(7682):639-643.
Not in our library10.1038/nature24637
219.
Terzi EM, Sviderskiy VO, Alvarez SW, Whiten GC, Possemato R. Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5. Sci Adv. 2021;7(22):eabg4302.
Not in our library10.1126/sciadv.abg4302
220.
Lee J, Shin D, Roh JL. Lipid metabolism alterations and ferroptosis in cancer: Paving the way for solving cancer resistance. Eur J Pharmacol. 2023;941:175497.
Not in our library10.1016/j.ejphar.2023.175497
221.
Dierge E, Debock E, Guilbaud C, Corbet C, Mignolet E, Mignard L, et al. Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects. Cell Metab. 2021;33(8):1701-15.e5.
Not in our library10.1016/j.cmet.2021.05.016
222.
Ma X, Xiao L, Liu L, Ye L, Su P, Bi E, et al. CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability. Cell Metab. 2021;33(5):1001-12.e5.
Not in our library10.1016/j.cmet.2021.02.015
223.
Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, et al. CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569(7755):270-274.
Not in our library10.1038/s41586-019-1170-y
224.
Yao Y, Chen Z, Zhang H, Chen C, Zeng M, Yunis J, et al. Selenium-GPX4 axis protects follicular helper T cells from ferroptosis. Nat Immunol. 2021;22(9):1127-1139.
Not in our library10.1038/s41590-021-00996-0
225.
Zheng H, Jiang L, Tsuduki T, Conrad M, Toyokuni S. Embryonal erythropoiesis and aging exploit ferroptosis. Redox Biol. 2021;48:102175.
Not in our library10.1016/j.redox.2021.102175
226.
Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, et al. Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways. Biomed Pharmacother. 2023;157:114048.
Not in our library10.1016/j.biopha.2022.114048
227.
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans · 2020
No notice
228.
Shen Q, Liang M, Yang F, Deng YZ, Naqvi NI. Ferroptosis contributes to developmental cell death in rice blast. New Phytol. 2020;227(6):1831-1846.
Not in our library10.1111/nph.16636
229.
Zhang L, Li XM, Shi XH, Ye K, Fu XL, Wang X, et al. Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma. Acta Pharmacol Sin. 2023;44(3):622-634.
Not in our library10.1038/s41401-022-00981-9
230.
Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, et al. Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression. Cell Res. 2023;33(4):299-311.
Not in our library10.1038/s41422-023-00788-1
231.
Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, et al. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nat Cell Biol. 2023;25(5):714-725.
Not in our library10.1038/s41556-023-01133-9
232.
Cui X, Yun X, Sun M, Li R, Lyu X, Lao Y, et al. HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility. Hepatol Int. 2023;17(2):377-392.
Not in our library10.1007/s12072-022-10459-9
233.
Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth · 2023
No notice
234.
Xu FL, Wu XH, Chen C, Wang K, Huang LY, Xia J, et al. SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase. Cell Death Dis. 2023;14(1):22.
Not in our library10.1038/s41419-023-05558-w
235.
Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, et al. ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1. Nat Cancer. 2022;3(1):75-89.
Not in our library10.1038/s43018-021-00299-1
236.
Chen Y, Li L, Lan J, Cui Y, Rao X, Zhao J, et al. CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma. Mol Cancer. 2022;21(1):11.
Not in our library10.1186/s12943-021-01466-9
237.
Zhang X, Zheng Q, Yue X, Yuan Z, Ling J, Yuan Y, et al. ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation. J Exp Clin Cancer Res. 2022;41(1):79.
Not in our library10.1186/s13046-022-02288-3
238.
Wang Y, Zhao M, Zhao L, Geng Y, Li G, Chen L, et al. HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression. Cancer Res. 2023;83(7):1048-1061.
Not in our library10.1158/0008-5472.can-22-3169
239.
Liu J, Liu Y, Wang Y, Li C, Xie Y, Klionsky DJ, et al. TMEM164 is a new determinant of autophagy-dependent ferroptosis. Autophagy. 2023;19(3):945-956.
Not in our library10.1080/15548627.2022.2111635
240.
CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1 · 2022
No notice
241.
Guo S, Deng J, Wang P, Kou F, Wu Z, Zhang N, et al. The malignancy suppression and ferroptosis facilitation of BCL6 in gastric cancer mediated by FZD7 repression are strengthened by RNF180/RhoC pathway. Cell Biosci. 2023;13(1):73.
Not in our library10.1186/s13578-023-01020-8
242.
Qu X, Liu B, Wang L, Liu L, Zhao W, Liu C, et al. Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer. Drug Resist Updat. 2023;68:100936.
Not in our library10.1016/j.drup.2023.100936
243.
CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer · 2023
No notice
244.
Liu MY, Li HM, Wang XY, Xia R, Li X, Ma YJ, et al. TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway. Free Radic Biol Med. 2022;182:219-231.
Not in our library10.1016/j.freeradbiomed.2022.03.002
245.
Chen L, Cai Q, Yang R, Wang H, Ling H, Li T, et al. GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail. Proc Natl Acad Sci U S A. 2023;120(15):e2219585120.
Not in our library10.1073/pnas.2219585120
246.
Xu X, Cui J, Wang H, Ma L, Zhang X, Guo W, et al. IGF2BP3 is an essential N(6)-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells. Mater Today Bio. 2022;17:100503.
Not in our library10.1016/j.mtbio.2022.100503
247.
Wang Q, Gao S, Shou Y, Jia Y, Wei Z, Liu Y, et al. AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis. Int J Biol Sci. 2023;19(4):1266-1283.
Not in our library10.7150/ijbs.79853
248.
Zheng J, Zhang Q, Zhao Z, Qiu Y, Zhou Y, Wu Z, et al. Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1. J Exp Clin Cancer Res. 2023;42(1):127.
Not in our library10.1186/s13046-023-02684-3
249.
Liu Y, Chou FJ, Lang F, Zhang M, Song H, Zhang W, et al. Protein kinase B (PKB/AKT) protects IDH-Mutated glioma from ferroptosis via Nrf2. Clin Cancer Res. 2023;29(7):1305-1316.
Not in our library10.1158/1078-0432.ccr-22-3179
250.
Wen RJ, Dong X, Zhuang HW, Pang FX, Ding SC, Li N, et al. Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis. Phytomedicine. 2023;116:154881.
Not in our library10.1016/j.phymed.2023.154881
251.
Ding Z, Liang X, Wang J, Song Z, Guo Q, Schafer MKE, et al. Inhibition of spinal ferroptosis-like cell death alleviates hyperalgesia and spontaneous pain in a mouse model of bone cancer pain. Redox Biol. 2023;62:102700.
Not in our library10.1016/j.redox.2023.102700
252.
Su Z, Kon N, Yi J, Zhao H, Zhang W, Tang Q, et al. Specific regulation of BACH1 by the hotspot mutant p53(R175H) reveals a distinct gain-of-function mechanism. Nat Cancer. 2023;4(4):564-581.
Not in our library10.1038/s43018-023-00532-z
253.
Asif K, Adeel M, Rahman MM, Caligiuri I, Perin T, Cemazar M, et al. Iron nitroprusside as a chemodynamic agent and inducer of ferroptosis for ovarian cancer therapy. J Mater Chem B. 2023;11(14):3124-3135.
Not in our library10.1039/d2tb02691k
254.
Zhang X, Zheng X, Ying X, Xie W, Yin Y, Wang X. CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer. J Transl Med. 2023;21(1):334.
Not in our library10.1186/s12967-023-04136-0
255.
Anandhan A, Dodson M, Shakya A, Chen J, Liu P, Wei Y, et al. NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8. Sci Adv. 2023;9(5):eade9585.
Not in our library10.1126/sciadv.ade9585
256.
Wang CK, Chen TJ, Tan GYT, Chang FP, Sridharan S, Yu CA, et al. MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis. Cancer Res. 2023;83(2):251-263.
Not in our library10.1158/0008-5472.can-22-1159
257.
Wang ME, Chen J, Lu Y, Bawcom AR, Wu J, Ou J et al. RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis. J Clin Invest. 2023;133(10). 10.1172/JCI166647.
Not in our library10.1172/jci166647
258.
Cheng L, He Q, Liu B, Chen L, Lv F, Li X, et al. SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4. Cell Death Dis. 2023;14(1):74.
Not in our library10.1038/s41419-023-05614-5
259.
Jiang K, Yin X, Zhang Q, Yin J, Tang Q, Xu M, et al. STC2 activates PRMT5 to induce radioresistance through DNA damage repair and ferroptosis pathways in esophageal squamous cell carcinoma. Redox Biol. 2023;60:102626.
Not in our library10.1016/j.redox.2023.102626
260.
Wang S, Yi X, Wu Z, Guo S, Dai W, Wang H, et al. CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK-NRF2 Pathway. J Invest Dermatol. 2022;142(1):189-200.e8.
Not in our library10.1016/j.jid.2021.05.025
261.
Zhang H-L, Hu B-X, Li Z-L, Du T, Shan J-L, Ye Z-P, et al. PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis. Nat Cell Biol. 2022;24(1):88-98.
Not in our library10.1038/s41556-021-00818-3
262.
Wang S, Wang Y, Li Q, Zeng K, Li X, Feng X. RUNX1-IT1 favors breast cancer carcinogenesis through regulation of IGF2BP1/GPX4 axis. Discov Oncol. 2023;14(1):42.
Not in our library10.1007/s12672-023-00652-z
263.
HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk · 2022
No notice
264.
Wang YF, Feng JY, Zhao LN, Zhao M, Wei XF, Geng Y et al. Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription. Acta Pharmacol Sin. 2023. 10.1038/s41401-023-01062-1.
Not in our library10.1038/s41401-023-01062-1
265.
Zhu ZH, Xu XT, Shen CJ, Yuan JT, Lou SY, Ma XL, et al. A novel sesquiterpene lactone fraction from Eupatorium chinense L. suppresses hepatocellular carcinoma growth by triggering ferritinophagy and mitochondrial damage. Phytomedicine. 2023;112:154671.
Not in our library10.1016/j.phymed.2023.154671
266.
Xi J, Tian LL, Xi J, Girimpuhwe D, Huang C, Ma R, et al. Alterperylenol as a novel thioredoxin reductase inhibitor induces liver cancer cell apoptosis and ferroptosis. J Agric Food Chem. 2022;70(50):15763-15775.
Not in our library10.1021/acs.jafc.2c05339
267.
Liu X, Peng X, Cen S, Yang C, Ma Z, Shi X. Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis. Front Pharmacol. 2023;14:1129662.
Not in our library10.3389/fphar.2023.1129662
268.
Xue Q, Yan D, Chen X, Li X, Kang R, Klionsky DJ et al. Copper-dependent autophagic degradation of GPX4 drives ferroptosis. Autophagy. 2023:1–15. 10.1080/15548627.2023.2165323.
Not in our library10.1080/15548627.2023.2165323
269.
Cui W, Zhang J, Wu D, Zhang J, Zhou H, Rong Y, et al. Ponicidin suppresses pancreatic cancer growth by inducing ferroptosis: Insight gained by mass spectrometry-based metabolomics. Phytomedicine. 2022;98:153943.
Not in our library10.1016/j.phymed.2022.153943
270.
Zheng F, Wang Y, Zhang Q, Chen Q, Liang CL, Liu H, et al. Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis. Front Pharmacol. 2023;14:1145407.
Not in our library10.3389/fphar.2023.1145407
271.
Xu X, Li Y, Wu Y, Wang M, Lu Y, Fang Z, et al. Increased ATF2 expression predicts poor prognosis and inhibits sorafenib-induced ferroptosis in gastric cancer. Redox Biol. 2023;59:102564.
Not in our library10.1016/j.redox.2022.102564
272.
Bian Z, Sun X, Liu L, Qin Y, Zhang Q, Liu H et al. Sodium butyrate induces CRC cell ferroptosis via the CD44/SLC7A11 pathway and exhibits a synergistic therapeutic effect with erastin. Cancers (Basel). 2023;15(2). 10.3390/cancers15020423.
Not in our library10.3390/cancers15020423
273.
Miao Q, Deng WQ, Lyu WY, Sun ZT, Fan SR, Qi M et al. Erianin inhibits the growth and metastasis through autophagy-dependent ferroptosis in KRAS(G13D) colorectal cancer. Free Radic Biol Med. 2023. 10.1016/j.freeradbiomed.2023.05.008.
Not in our library10.1016/j.freeradbiomed.2023.05.008
274.
Zhu JF, Liu Y, Li WT, Li MH, Zhen CH, Sun PW, et al. Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway. Cell Death Dis. 2023;14(2):151.
Not in our library10.1038/s41419-023-05664-9
275.
Guo S, Zhao W, Zhang W, Li S, Teng G, Liu L. Vitamin D promotes ferroptosis in colorectal cancer stem cells via SLC7A11 downregulation. Oxid Med Cell Longev. 2023;2023:4772134.
Not in our library10.1155/2023/4772134
276.
Hao J, Chen Q, Feng Y, Jiang Q, Sun H, Deng B, et al. Combination treatment with FAAH inhibitors/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway. Cell Death Dis. 2023;14(4):247.
Not in our library10.1038/s41419-023-05779-z
277.
Kang L, Wang D, Shen T, Liu X, Dai B, Zhou D, et al. PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma. Cell Death Dis. 2023;14(3):193.
Not in our library10.1038/s41419-023-05719-x
278.
Xu C, Jiang ZB, Shao L, Zhao ZM, Fan XX, Sui X, et al. β-Elemene enhances erlotinib sensitivity through induction of ferroptosis by upregulating lncRNA H19 in EGFR-mutant non-small cell lung cancer. Pharmacol Res. 2023;191:106739.
Not in our library10.1016/j.phrs.2023.106739
279.
Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation · 2023
No notice
280.
Zhang W, Jiang B, Liu Y, Xu L, Wan M. Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4. Free Radic Biol Med. 2022;180:75-84.
Not in our library10.1016/j.freeradbiomed.2022.01.009
281.
Han N, Yang ZY, Xie ZX, Xu HZ, Yu TT, Li QR, et al. Dihydroartemisinin elicits immunogenic death through ferroptosis-triggered ER stress and DNA damage for lung cancer immunotherapy. Phytomedicine. 2023;112:154682.
Not in our library10.1016/j.phymed.2023.154682
282.
Hu CY, Wu HT, Shan YS, Wang CT, Shieh GS, Wu CL et al. Evodiamine exhibits anti-bladder cancer activity by suppression of glutathione peroxidase 4 and induction of ferroptosis. Int J Mol Sci. 2023;24(7). 10.3390/ijms24076021.
Not in our library10.3390/ijms24076021
283.
Cai J, Ye Z, Hu Y, Ye L, Gao L, Wang Y, et al. Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma. Cell Death Dis. 2023;14(3):211.
Not in our library10.1038/s41419-023-05738-8
284.
Ni M, Zhou J, Zhu Z, Xu Q, Yin Z, Wang Y, et al. Shikonin and cisplatin synergistically overcome cisplatin resistance of ovarian cancer by inducing ferroptosis via upregulation of HMOX1 to promote Fe(2+) accumulation. Phytomedicine. 2023;112:154701.
Not in our library10.1016/j.phymed.2023.154701
285.
Mao G, Xin D, Wang Q, Lai D. Sodium molybdate inhibits the growth of ovarian cancer cells via inducing both ferroptosis and apoptosis. Free Radic Biol Med. 2022;182:79-92.
Not in our library10.1016/j.freeradbiomed.2022.02.023
286.
Cao YY, Chen YY, Wang MS, Tong JJ, Xu M, Zhao C, et al. A catalase inhibitor: Targeting the NADPH-binding site for castration-resistant prostate cancer therapy. Redox Biol. 2023;63:102751.
Not in our library10.1016/j.redox.2023.102751
287.
Zhao P, Song H, Gao F, Chen L, Qiu J, Jin J et al. A novel derivative of curcumol, HCL-23, inhibits the malignant phenotype of triple-negative breast cancer and induces apoptosis and HO-1-dependent ferroptosis. Molecules. 2023;28(8). 10.3390/molecules28083389.
Not in our library10.3390/molecules28083389
288.
Zhang B, Hou Q, Zhang X, Ma Y, Yuan J, Li S, et al. Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation. Free Radic Biol Med. 2023;195:298-308.
Not in our library10.1016/j.freeradbiomed.2022.12.092
289.
Chen H, Li Z, Xu J, Zhang N, Chen J, Wang G, et al. Curcumin induces ferroptosis in follicular thyroid cancer by upregulating HO-1 expression. Oxid Med Cell Longev. 2023;2023:6896790.
Not in our library10.1155/2023/6896790
290.
Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov. 2022;12(1):31-46.
Not in our library10.1158/2159-8290.cd-21-1059
291.
Advancing Cancer Therapy. Nature Cancer. 2021;2(3):245-6. 10.1038/s43018-021-00192-x.
Not in our library10.1038/s43018-021-00192-x
292.
Saito A, Toyoda H, Kobayashi M, Koiwa Y, Fujii H, Fujita K, et al. Prediction of early recurrence of hepatocellular carcinoma after resection using digital pathology images assessed by machine learning. Mod Pathol. 2021;34(2):417-425.
Not in our library10.1038/s41379-020-00671-z
293.
Poh AR, Ernst M. Functional roles of SRC signaling in pancreatic cancer: Recent insights provide novel therapeutic opportunities. Oncogene. 2023;42(22):1786-1801.
Not in our library10.1038/s41388-023-02701-x
294.
Ferroptosis in cancer therapy: a novel approach to reversing drug resistance · 2022
No notice
295.
Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, et al. A reactivity-based probe of the intracellular labile ferrous iron pool. Nat Chem Biol. 2016;12(9):680-685.
Not in our library10.1038/nchembio.2116
296.
Chen X, Kang R, Kroemer G, Tang D. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18(5):280-296.
Not in our library10.1038/s41571-020-00462-0
297.
Kim E, Han DJ, Kim BH, Yoo J, Kim HJ, Wu HG, et al. Whole-genome sequencing reveals mutational signatures related to radiation-induced sarcomas and DNA-damage-repair pathways. Mod Pathol. 2023;36(1):100004.
Not in our library10.1016/j.modpat.2022.100004
298.
Meng Z, Lu J, Ge G, Wang G, Zhang R, Li Y, et al. Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB. Food Funct. 2023;14(1):240-249.
Not in our library10.1039/d2fo02719d
299.
Truong H, Breen K, Nandakumar S, Sjoberg DD, Kemel Y, Mehta N, et al. Gene-based confirmatory germline testing following tumor-only sequencing of prostate cancer. Eur Urol. 2023;83(1):29-38.
Not in our library10.1016/j.eururo.2022.08.028
300.
Pennington KL, McEwan CM, Woods J, Muir CM, Pramoda Sahankumari AG, Eastmond R, et al. SGK2, 14–3-3, and HUWE1 cooperate to control the localization, stability, and function of the oncoprotein PTOV1. Mol Cancer Res. 2022;20(2):231-243.
Not in our library10.1158/1541-7786.mcr-20-1076
301.
Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J, Karlan BY. Ovarian cancer. Nat Rev Dis Primers. 2016;2:16061.
Not in our library10.1038/nrdp.2016.61
302.
Vasan N, Baselga J, Hyman DM. A view on drug resistance in cancer. Nature. 2019;575(7782):299-309.
Not in our library10.1038/s41586-019-1730-1
303.
Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy · 2019
No notice
304.
Sharifi-Rad J, Herrera-Bravo J, Salazar LA, Shaheen S, Abdulmajid Ayatollahi S, Kobarfard F, et al. The therapeutic potential of wogonin observed in preclinical studies. Evid Based Complement Alternat Med. 2021;2021:9935451.
Not in our library10.1155/2021/9935451
305.
Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS. Lung cancer. Lancet. 2021;398(10299):535-554.
Not in our library10.1016/s0140-6736(21)00312-3
306.
Fan G, Wei X, Xu X. Is the era of sorafenib over? A review of the literature. Ther Adv Med Oncol. 2020;12:1758835920927602.
Not in our library10.1177/1758835920927602
307.
The Role of Ferroptosis in Cancer Development and Treatment Response · 2018
No notice
308.
Li B, Yang L, Peng X, Fan Q, Wei S, Yang S, et al. Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers. Biomed Pharmacother. 2020;130:110710.
Not in our library10.1016/j.biopha.2020.110710
309.
Mikubo M, Inoue Y, Liu G, Tsao MS. Mechanism of drug tolerant persister cancer cells: The landscape and clinical implication for therapy. J Thorac Oncol. 2021;16(11):1798-1809.
Not in our library10.1016/j.jtho.2021.07.017
310.
Zhang Z, Tan Y, Huang C, Wei X. Redox signaling in drug-tolerant persister cells as an emerging therapeutic target. EBioMedicine. 2023;89:104483.
Not in our library10.1016/j.ebiom.2023.104483
311.
Qi R, Bai Y, Li K, Liu N, Xu Y, Dal E, et al. Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs. Drug Resist Updat. 2023;68:100960.
Not in our library10.1016/j.drup.2023.100960
312.
Xiong K, Wang Z, Hounye AH, Peng L, Zhang J, Qi M. Development and validation of ferroptosis-related lncRNA signature and immune-related gene signature for predicting the prognosis of cutaneous melanoma patients. Apoptosis. 2023;28(5–6):840-859.
Not in our library10.1007/s10495-023-01831-7
313.
Yan H, Talty R, Jain A, Cai Y, Zheng J, Shen X, et al. Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations. Redox Biol. 2023;62:102699.
Not in our library10.1016/j.redox.2023.102699
314.
Chen H, Yin L, Yang J, Ren N, Chen J, Lu Q, et al. Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy. Cancer Biol Med. 2023;20(4):297-316.
Not in our library10.20892/j.issn.2095-3941.2022.0711
315.
Liu S, Zhang HL, Li J, Ye ZP, Du T, Li LC, et al. Tubastatin A potently inhibits GPX4 activity to potentiate cancer radiotherapy through boosting ferroptosis. Redox Biol. 2023;62:102677.
Not in our library10.1016/j.redox.2023.102677
316.
Wang C, Zheng C, Wang H, Shui S, Jin H, Liu G, et al. Dual degradation mechanism of GPX4 degrader in induction of ferroptosis exerting anti-resistant tumor effect. Eur J Med Chem. 2023;247:115072.
Not in our library10.1016/j.ejmech.2022.115072
317.
Gu Y, Li Y, Wang J, Zhang L, Zhang J, Wang Y. Targeting ferroptosis: Paving new roads for drug design and discovery. Eur J Med Chem. 2023;247:115015.
Not in our library10.1016/j.ejmech.2022.115015
318.
Zhang X, Xu X, Liu H, Ni N, Liu S, Gong Y et al. CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy. Acta Biomater. 2023. 10.1016/j.actbio.2023.05.006.
Not in our library10.1016/j.actbio.2023.05.006
319.
Zhang Z, Lo H, Zhao X, Li W, Wu K, Zeng F, et al. Mild photothermal/radiation therapy potentiates ferroptosis effect for ablation of breast cancer via MRI/PA imaging guided all-in-one strategy. J Nanobiotechnology. 2023;21(1):150.
Not in our library10.1186/s12951-023-01910-6
320.
Chen Y, Yao Z, Liu P, Hu Q, Huang Y, Ping L, et al. A self-assembly nano-prodrug for triple-negative breast cancer combined treatment by ferroptosis therapy and chemotherapy. Acta Biomater. 2023;159:275-288.
Not in our library10.1016/j.actbio.2023.01.050
321.
Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies · 2019
No notice
322.
Heusch G. Myocardial ischaemia–reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol. 2020;17(12):773-789.
Not in our library10.1038/s41569-020-0403-y
323.
Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. J Pathol. 2000;190(3):255-266.
Not in our library10.1002/(sici)1096-9896(200002)190:3<255::aid-path526>3.0.co;2-6
324.
Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, et al. Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem. 2018;46(4):1650-1667.
Not in our library10.1159/000489241
325.
Chen C, Zheng M, Hou H, Fang S, Chen L, Yang J, et al. Cellular senescence in ischemia/reperfusion injury. Cell Death Discov. 2022;8(1):420.
Not in our library10.1038/s41420-022-01205-z
326.
Verma S, Fedak PW, Weisel RD, Butany J, Rao V, Maitland A, et al. Fundamentals of reperfusion injury for the clinical cardiologist. Circulation. 2002;105(20):2332-2336.
Not in our library10.1161/01.cir.0000016602.96363.36
327.
Mandalaneni K, Rayi A, Jillella DV. Stroke reperfusion injury. 2023.
Not in our library
328.
Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury · 2020
No notice
329.
Slegtenhorst BR, Dor FJ, Rodriguez H, Voskuil FJ, Tullius SG. Ischemia/reperfusion injury and its consequences on immunity and inflammation. Curr Transplant Rep. 2014;1(3):147-154.
Not in our library10.1007/s40472-014-0017-6
330.
Sanchez-Hernandez CD, Torres-Alarcon LA, Gonzalez-Cortes A, Peon AN. Ischemia/reperfusion injury: pathophysiology, current clinical management, and potential preventive approaches. Mediators Inflamm. 2020;2020:8405370.
Not in our library10.1155/2020/8405370
331.
Zhou Y, He Y, Yan S, Chen L, Zhang R, Xu J, et al. Reperfusion injury is associated with poor outcome in patients with recanalization after thrombectomy. Stroke. 2023;54(1):96-104.
Not in our library10.1161/strokeaha.122.039337
332.
Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair · 2020
No notice
333.
Fernandez AR, Sanchez-Tarjuelo R, Cravedi P, Ochando J, Lopez-Hoyos M. Review: Ischemia Reperfusion Injury-A Translational Perspective in Organ Transplantation. Int J Mol Sci. 2020;21(22). 10.3390/ijms21228549.
Not in our library10.3390/ijms21228549
334.
Li N, Jiang W, Wang W, Xiong R, Wu X, Geng Q. Ferroptosis and its emerging roles in cardiovascular diseases. Pharmacol Res. 2021;166:105466.
Not in our library10.1016/j.phrs.2021.105466
335.
Eefting F, Rensing B, Wigman J, Pannekoek WJ, Liu WM, Cramer MJ, et al. Role of apoptosis in reperfusion injury. Cardiovasc Res. 2004;61(3):414-426.
Not in our library10.1016/j.cardiores.2003.12.023
336.
Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol. 2012;298:229-317.
Not in our library10.1016/b978-0-12-394309-5.00006-7
337.
Zhou L, Han S, Guo J, Qiu T, Zhou J, Shen L. Ferroptosis-a new dawn in the treatment of organ ischemia-reperfusion injury. Cells. 2022;11(22). 10.3390/cells11223653.
Not in our library10.3390/cells11223653
338.
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion · 2019
No notice
339.
Cai W, Liu L, Shi X, Liu Y, Wang J, Fang X, et al. Alox15/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis. Circulation. 2023;147(19):1444-1460.
Not in our library10.1161/circulationaha.122.060257
340.
Jiang YQ, Yang XY, Duan DQ, Zhang YY, Li NS, Tang LJ, et al. Inhibition of MALT1 reduces ferroptosis in rat hearts following ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway. Eur J Pharmacol. 2023;950:175774.
Not in our library10.1016/j.ejphar.2023.175774
341.
Ji JJ, Chen SY, Yang ZW, Zhang R, Qian LL, Jiang Y, et al. Delivery of Mir-196c-3p with NIR-II light-triggered gel attenuates cardiomyocyte ferroptosis in cardiac ischemia-reperfusion injury. Nanomedicine. 2023;47:102618.
Not in our library10.1016/j.nano.2022.102618
342.
Zhang JK, Zhang Z, Guo ZA, Fu Y, Chen XJ, Chen WJ, et al. The BMSC-derived exosomal lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2/PRDX6 axis. Nutr Metab Cardiovasc Dis. 2022;32(2):515-527.
Not in our library10.1016/j.numecd.2021.10.017
343.
Tang LJ, Zhou YJ, Xiong XM, Li NS, Zhang JJ, Luo XJ, et al. Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion. Free Radic Biol Med. 2021;162:339-352.
Not in our library10.1016/j.freeradbiomed.2020.10.307
344.
Liu H, Mo H, Yang C, Mei X, Song X, Lu W, et al. A novel function of ATF3 in suppression of ferroptosis in mouse heart suffered ischemia/reperfusion. Free Radic Biol Med. 2022;189:122-135.
Not in our library10.1016/j.freeradbiomed.2022.07.006
345.
Zhuang Y, Yang D, Shi S, Wang L, Yu M, Meng X, et al. MiR-375-3p promotes cardiac fibrosis by regulating the ferroptosis mediated by GPX4. Comput Intell Neurosci. 2022;2022:9629158.
Not in our library10.1155/2022/9629158
346.
Wu T, Shi G, Ji Z, Wang S, Geng L, Guo Z. Circulating small extracellular vesicle-encapsulated SEMA5A-IT1 attenuates myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass. Cell Mol Biol Lett. 2022;27(1):95.
Not in our library10.1186/s11658-022-00395-9
347.
Zhang W, Qiao W, Zuo L. A(1) and A(2b) adenosine receptors regulate GPX4 against ferroptosis of cardiomyocytes in myocardial infarction rat model and in vitro. Tissue Cell. 2022;77:101828.
Not in our library10.1016/j.tice.2022.101828
348.
Zhang GY, Gao Y, Guo XY, Wang GH, Guo CX. MiR-199a-5p promotes ferroptosis-induced cardiomyocyte death responding to oxygen-glucose deprivation/reperfusion injury via inhibiting Akt/eNOS signaling pathway. Kaohsiung J Med Sci. 2022;38(11):1093-1102.
Not in our library10.1002/kjm2.12605
349.
USP22 Protects Against Myocardial Ischemia–Reperfusion Injury via the SIRT1-p53/SLC7A11–Dependent Inhibition of Ferroptosis–Induced Cardiomyocyte Death · 2020
Retracted
350.
Activation of NRF2/FPN1 pathway attenuates myocardial ischemia–reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis · 2022
No notice
351.
Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury · 2021
No notice
352.
Stamenkovic A, O'Hara KA, Nelson DC, Maddaford TG, Edel AL, Maddaford G, et al. Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2021;320(3):H1170-H1184.
Not in our library10.1152/ajpheart.00237.2020
353.
ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy · 2021
Corrected
354.
miR-135b-3p Promotes Cardiomyocyte Ferroptosis by Targeting GPX4 and Aggravates Myocardial Ischemia/Reperfusion Injury · 2021
Not checked
355.
Sun W, Wu X, Yu P, Zhang Q, Shen L, Chen J, et al. LncAABR07025387.1 enhances myocardial ischemia/reperfusion injury via miR-205/ACSL4-mediated ferroptosis. Front Cell Dev Biol. 2022;10:672391.
Not in our library10.3389/fcell.2022.672391
356.
Hu M, Huang J, Chen L, Sun XR, Yao ZM, Tong XH, et al. Upregulation of CDGSH iron sulfur domain 2 attenuates cerebral ischemia/reperfusion injury. Neural Regen Res. 2023;18(7):1512-1520.
Not in our library10.4103/1673-5374.355766
357.
Liu Q, Liu Y, Li Y, Hong Z, Li S, Liu C. PUM2 aggravates the neuroinflammation and brain damage induced by ischemia-reperfusion through the SLC7A11-dependent inhibition of ferroptosis via suppressing the SIRT1. Mol Cell Biochem. 2023;478(3):609-620.
Not in our library10.1007/s11010-022-04534-w
358.
Xiong L, Zhang J, Shi H, Zhu G, Ji X, Li M, et al. Downregulation of TNFAIP1 alleviates OGD/R-induced neuronal damage by suppressing Nrf2/GPX4-mediated ferroptosis. Exp Ther Med. 2023;25(1):25.
Not in our library10.3892/etm.2022.11724
359.
Yang J, Guo Q, Wang L, Yu S. POU domain class 2 transcription factor 2 inhibits ferroptosis in cerebral ischemia reperfusion injury by activating sestrin2. Neurochem Res. 2023;48(2):658-670.
Not in our library10.1007/s11064-022-03791-x
360.
Zhang T, Yang M, Ma C, Wei X, Zhang Z. BACH1 encourages ferroptosis by activating KDM4C-mediated COX2 demethylation after cerebral ischemia-reperfusion injury. Eur J Neurosci. 2023. 10.1111/ejn.16035.
Not in our library10.1111/ejn.16035
361.
Tuo QZ, Lei P, Jackman KA, Li XL, Xiong H, Li XL, et al. Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Mol Psychiatry. 2017;22(11):1520-1530.
Not in our library10.1038/mp.2017.171
362.
Li C, Sun G, Chen B, Xu L, Ye Y, He J, et al. Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke. Pharmacol Res. 2021;174:105933.
Not in our library10.1016/j.phrs.2021.105933
363.
Chen W, Jiang L, Hu Y, Tang N, Liang N, Li XF, et al. Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53/SLC7A11-mediated ferroptosis. Brain Res. 2021;1752:147216.
Not in our library10.1016/j.brainres.2020.147216
364.
Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis · 2021
No notice
365.
Huang Y, Liu J, He J, Hu Z, Tan F, Zhu X, et al. UBIAD1 alleviates ferroptotic neuronal death by enhancing antioxidative capacity by cooperatively restoring impaired mitochondria and Golgi apparatus upon cerebral ischemic/reperfusion insult. Cell Biosci. 2022;12(1):42.
Not in our library10.1186/s13578-022-00776-9
366.
Xu Y, Liu Y, Li K, Yuan D, Yang S, Zhou L, et al. COX-2/PGE2 pathway inhibits the ferroptosis induced by cerebral ischemia reperfusion. Mol Neurobiol. 2022;59(3):1619-1631.
Not in our library10.1007/s12035-021-02706-1
367.
Zhao J, Wu Y, Liang S, Piao X. Activation of SSAT1/ALOX15 Axis aggravates cerebral ischemia/reperfusion injury via triggering neuronal ferroptosis. Neuroscience. 2022;485:78-90.
Not in our library10.1016/j.neuroscience.2022.01.017
368.
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion · 2022
No notice
369.
Lu J, Xu F, Lu H. LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53. Life Sci. 2020;260:118305.
Not in our library10.1016/j.lfs.2020.118305
370.
Zou S, Sun H, Peng Y, Liang C, Zheng C, Wang L, et al. Mu-opioid receptor alleviated ferroptosis in hepatic ischemia-reperfusion injury via the HIF-1alpha/KCNQ1OT1 axis. Am J Physiol Cell Physiol. 2023;324(4):C927-C940.
Not in our library10.1152/ajpcell.00394.2022
371.
Li X, Wu L, Tian X, Zheng W, Yuan M, Tian X, et al. miR-29a-3p in exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells alleviates steatotic liver ischemia-reperfusion injury in rats by suppressing ferroptosis via iron responsive element binding protein 2. Oxid Med Cell Longev. 2022;2022:6520789.
Not in our library10.1155/2022/6520789
372.
Wu S, Yang J, Sun G, Hu J, Zhang Q, Cai J, et al. Macrophage extracellular traps aggravate iron overload-related liver ischaemia/reperfusion injury. Br J Pharmacol. 2021;178(18):3783-3796.
Not in our library10.1111/bph.15518
373.
Wu Y, Jiao H, Yue Y, He K, Jin Y, Zhang J, et al. Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury. Cell Death Differ. 2022;29(9):1705-1718.
Not in our library10.1038/s41418-022-00957-6
374.
Shi L, Song Z, Li Y, Huang J, Zhao F, Luo Y, et al. MiR-20a-5p alleviates kidney ischemia/reperfusion injury by targeting ACSL4-dependent ferroptosis. Am J Transplant. 2023;23(1):11-25.
Not in our library10.1016/j.ajt.2022.09.003
375.
Sun X, Huang N, Li P, Dong X, Yang J, Zhang X, et al. TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury. Life Sci. 2023;321:121608.
Not in our library10.1016/j.lfs.2023.121608
376.
Sun Z, Wu J, Bi Q, Wang W. Exosomal lncRNA TUG1 derived from human urine-derived stem cells attenuates renal ischemia/reperfusion injury by interacting with SRSF1 to regulate ASCL4-mediated ferroptosis. Stem Cell Res Ther. 2022;13(1):297.
Not in our library10.1186/s13287-022-02986-x
377.
Huang LL, Liao XH, Sun H, Jiang X, Liu Q, Zhang L. Augmenter of liver regeneration protects the kidney from ischaemia-reperfusion injury in ferroptosis. J Cell Mol Med. 2019;23(6):4153-4164.
Not in our library10.1111/jcmm.14302
378.
Su L, Jiang X, Yang C, Zhang J, Chen B, Li Y, et al. Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury. J Biol Chem. 2019;294(50):19395-19404.
Not in our library10.1074/jbc.ra119.010949
379.
Sui M, Xu D, Zhao W, Lu H, Chen R, Duan Y, et al. CIRBP promotes ferroptosis by interacting with ELAVL1 and activating ferritinophagy during renal ischaemia-reperfusion injury. J Cell Mol Med. 2021;25(13):6203-6216.
Not in our library10.1111/jcmm.16567
380.
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI · 2021
No notice
381.
Eleftheriadis T, Pissas G, Golfinopoulos S, Liakopoulos V, Stefanidis I. Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells. Mol Med Rep. 2021;23(6). 10.3892/mmr.2021.12111.
Not in our library10.3892/mmr.2021.12111
382.
Feng R, Xiong Y, Lei Y, Huang Q, Liu H, Zhao X, et al. Lysine-specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4/NOX4 pathway in mice. J Cell Mol Med. 2022;26(15):4254-4267.
Not in our library10.1111/jcmm.17444
383.
miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury · 2020
No notice
384.
miR-3587 Inhibitor Attenuates Ferroptosis Following Renal Ischemia-Reperfusion Through HO-1 · 2022
Not checked
385.
Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1 · 2020
No notice
386.
Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11 · 2020
No notice
387.
Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11 · 2021
No notice
388.
Li Y, Cao Y, Xiao J, Shang J, Tan Q, Ping F, et al. Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury. Cell Death Differ. 2020;27(9):2635-2650.
Not in our library10.1038/s41418-020-0528-x
389.
Rong Y, Fan J, Ji C, Wang Z, Ge X, Wang J, et al. USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1. Cell Death Differ. 2022;29(6):1164-1175.
Not in our library10.1038/s41418-021-00907-8
390.
Gerber Y, Weston SA, Jiang R, Roger VL. The changing epidemiology of myocardial infarction in Olmsted County, Minnesota, 1995–2012. Am J Med. 2015;128(2):144-151.
Not in our library10.1016/j.amjmed.2014.09.012
391.
Correction: Twenty-five-year trends in myocardial infarction attack and mortality rates, and case-fatality, in six European populations. Heart. 2018;104(16):e2. 10.1136/heartjnl-2014-307310corr1.
Not in our library10.1136/heartjnl-2014-307310corr1
392.
Degano IR, Salomaa V, Veronesi G, Ferrieres J, Kirchberger I, Laks T, et al. Twenty-five-year trends in myocardial infarction attack and mortality rates, and case-fatality, in six European populations. Heart. 2015;101(17):1413-1421.
Not in our library10.1136/heartjnl-2014-307310
393.
Velagaleti RS, Pencina MJ, Murabito JM, Wang TJ, Parikh NI, D'Agostino RB, et al. Long-term trends in the incidence of heart failure after myocardial infarction. Circulation. 2008;118(20):2057-2062.
Not in our library10.1161/circulationaha.108.784215
394.
Lewis EF, Moye LA, Rouleau JL, Sacks FM, Arnold JM, Warnica JW, et al. Predictors of late development of heart failure in stable survivors of myocardial infarction: the CARE study. J Am Coll Cardiol. 2003;42(8):1446-1453.
Not in our library10.1016/s0735-1097(03)01057-x
395.
Jaén RI, Val-Blasco A, Prieto P, Gil-Fernández M, Smani T, López-Sendón JL, et al. Innate immune receptors, key actors in cardiovascular diseases. JACC Basic Transl Sci. 2020;5(7):735-749.
Not in our library10.1016/j.jacbts.2020.03.015
396.
Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury · 2021
No notice
397.
Miyamoto HD, Ikeda M, Ide T, Tadokoro T, Furusawa S, Abe K, et al. Iron overload via heme degradation in the endoplasmic reticulum triggers ferroptosis in myocardial ischemia-reperfusion injury. JACC Basic Transl Sci. 2022;7(8):800-819.
Not in our library10.1016/j.jacbts.2022.03.012
398.
Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. Myocardial ischemia reperfusion injury: from basic science to clinical bedside. Semin Cardiothorac Vasc Anesth. 2012;16(3):123-132.
Not in our library10.1177/1089253211436350
399.
Huang C, Zhou S, Chen C, Wang X, Ding R, Xu Y, et al. Biodegradable redox-responsive AIEgen-based-covalent organic framework nanocarriers for long-term treatment of myocardial ischemia/reperfusion injury. Small. 2022;18(47):e2205062.
Not in our library10.1002/smll.202205062
400.
Li JY, Liu SQ, Yao RQ, Tian YP, Yao YM. A novel insight into the fate of cardiomyocytes in ischemia-reperfusion injury: from iron metabolism to ferroptosis. Front Cell Dev Biol. 2021;9:799499.
Not in our library10.3389/fcell.2021.799499
401.
ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage · 2022
No notice
402.
Lin JH, Yang KT, Lee WS, Ting PC, Luo YP, Lin DJ, et al. Xanthohumol protects the rat myocardium against ischemia/reperfusion injury-induced ferroptosis. Oxid Med Cell Longev. 2022;2022:9523491.
Not in our library10.1155/2022/9523491
403.
Chen W, Zhang Y, Wang Z, Tan M, Lin J, Qian X, et al. Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition. Front Pharmacol. 2023;14:1078205.
Not in our library10.3389/fphar.2023.1078205
404.
Zhao Y, Zhang X, Chen X, Wei Y. Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review). Int J Mol Med. 2022;49(2). 10.3892/ijmm.2021.5070.
Not in our library10.3892/ijmm.2021.5070
405.
Cetin N, Dasdelen D, Mogulkoc R, Menevse E, Baltaci AK. Role of exogenous putrescine in the status of energy, DNA damage, inflammation, and spermidine/spermine-n(1)- acetyltransferase in brain ischemia-reperfusion in rats. Iran J Basic Med Sci. 2022;25(5):597-603.
Not in our library10.22038/ijbms.2022.63733.14046
406.
Bu ZQ, Yu HY, Wang J, He X, Cui YR, Feng JC, et al. Emerging role of ferroptosis in the pathogenesis of ischemic stroke: a new therapeutic target? ASN Neuro. 2021;13:17590914211037505.
Not in our library10.1177/17590914211037505
407.
Yang L, Du B, Zhang S, Wang M. RXRγ attenuates cerebral ischemia-reperfusion induced ferroptosis in neurons in mice through transcriptionally promoting the expression of GPX4. Metab Brain Dis. 2022;37(5):1351-1363.
Not in our library10.1007/s11011-022-00988-5
408.
Chen Y, He W, Wei H, Chang C, Yang L, Meng J, et al. Srs11-92, a ferrostatin-1 analog, improves oxidative stress and neuroinflammation via Nrf2 signal following cerebral ischemia/reperfusion injury. CNS Neurosci Ther. 2023;29(6):1667-1677.
Not in our library10.1111/cns.14130
409.
Xu S, Li X, Li Y, Li X, Lv E, Zhang X, et al. Neuroprotective effect of Dl-3-n-butylphthalide against ischemia-reperfusion injury is mediated by ferroptosis regulation via the SLC7A11/GSH/GPX4 pathway and the attenuation of blood-brain barrier disruption. Front Aging Neurosci. 2023;15:1028178.
Not in our library10.3389/fnagi.2023.1028178
410.
Chen L, Huang J, Yao ZM, Sun XR, Tong XH, Hu M et al. Procyanidins alleviated cerebral ischemia/reperfusion injury by inhibiting ferroptosis via the Nrf2/HO-1 signaling pathway. Molecules. 2023;28(8). 10.3390/molecules28083582.
Not in our library10.3390/molecules28083582
411.
Peralta C, Jiménez-Castro MB, Gracia-Sancho J. Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu. J Hepatol. 2013;59(5):1094-1106.
Not in our library10.1016/j.jhep.2013.06.017
412.
Precision Navigation of Hepatic Ischemia–Reperfusion Injury Guided by Lysosomal Viscosity-Activatable NIR-II Fluorescence · 2022
No notice
413.
Gao F, Qiu X, Wang K, Shao C, Jin W, Zhang Z, et al. Targeting the hepatic microenvironment to improve ischemia/reperfusion injury: New insights into the immune and metabolic compartments. Aging Dis. 2022;13(4):1196-1214.
Not in our library10.14336/ad.2022.0109
414.
The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope? · 2020
No notice
415.
Ye J, Peng J, Liu K, Zhang T, Huang W. MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2022;323(3):G283-G293.
Not in our library10.1152/ajpgi.00354.2021
416.
Guo J, Song Z, Yu J, Li C, Jin C, Duan W, et al. Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis. Cell Death Dis. 2022;13(12):1072.
Not in our library10.1038/s41419-022-05518-w
417.
Qiu S, Li X, Zhang J, Shi P, Cao Y, Zhuang Y, et al. Neutrophil membrane-coated taurine nanoparticles protect against hepatic ischemia-reperfusion injury. Eur J Pharmacol. 2023;949:175712.
Not in our library10.1016/j.ejphar.2023.175712
418.
Qi D, Chen P, Bao H, Zhang L, Sun K, Song S, et al. Dimethyl fumarate protects against hepatic ischemia-reperfusion injury by alleviating ferroptosis via the NRF2/SLC7A11/HO-1 axis. Cell Cycle. 2023;22(7):818-828.
Not in our library10.1080/15384101.2022.2155016
419.
Sharfuddin AA, Molitoris BA. Pathophysiology of ischemic acute kidney injury. Nat Rev Nephrol. 2011;7(4):189-200.
Not in our library10.1038/nrneph.2011.16
420.
Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 2011;121(11):4210-4221.
Not in our library10.1172/jci45161
421.
Reuter S, Mrowka R. Acute kidney injury. Acta Physiol (Oxf). 2015;215(2):73-75.
Not in our library10.1111/apha.12555
422.
Mechanisms and therapeutic targets of ischemic acute kidney injury · 2019
Not checked
423.
Thapa K, Singh TG, Kaur A. Targeting ferroptosis in ischemia/reperfusion renal injury. Naunyn Schmiedebergs Arch Pharmacol. 2022;395(11):1331-1341.
Not in our library10.1007/s00210-022-02277-5
424.
Wang Y, Quan F, Cao Q, Lin Y, Yue C, Bi R, et al. Quercetin alleviates acute kidney injury by inhibiting ferroptosis. J Adv Res. 2021;28:231-243.
Not in our library10.1016/j.jare.2020.07.007
425.
Du YW, Li XK, Wang TT, Zhou L, Li HR, Feng L, et al. Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway. Mol Med. 2023;29(1):42.
Not in our library10.1186/s10020-023-00642-5
426.
Qi Y, Hu M, Qiu Y, Zhang L, Yan Y, Feng Y, et al. Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET. Toxicol Appl Pharmacol. 2023;465:116440.
Not in our library10.1016/j.taap.2023.116440
427.
Zhang Y, Ren X, Wang Y, Chen D, Jiang L, Li X, et al. Targeting ferroptosis by polydopamine nanoparticles protects heart against ischemia/reperfusion injury. ACS Appl Mater Interfaces. 2021;13(45):53671-53682.
Not in our library10.1021/acsami.1c18061
428.
He P, Zhang M, Zhao M, Zhang M, Ma B, Lv H, et al. A novel polysaccharide from chuanminshen violaceum and its protective effect against myocardial injury. Front Nutr. 2022;9:961182.
Not in our library10.3389/fnut.2022.961182
429.
Peng Y, Liao B, Zhou Y, Zeng W, Zeng ZY. Atorvastatin inhibits ferroptosis of H9C2 cells by regulatingSMAD7/Hepcidin expression to improve ischemia-reperfusion injury. Cardiol Res Pract. 2022;2022:3972829.
Not in our library10.1155/2022/3972829
430.
Wang Z, Yao M, Jiang L, Wang L, Yang Y, Wang Q, et al. Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3beta/Nrf2 axis. Biomed Pharmacother. 2022;154:113572.
Not in our library10.1016/j.biopha.2022.113572
431.
Ma X, Xu J, Gao N, Tian J, Song T. Dexmedetomidine attenuates myocardial ischemia-reperfusion injury via inhibiting ferroptosis by the cAMP/PKA/CREB pathway. Mol Cell Probes. 2023;68:101899.
Not in our library10.1016/j.mcp.2023.101899
432.
Li T, Tan Y, Ouyang S, He J, Liu L. Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis. Gene. 2022;808:145968.
Not in our library10.1016/j.gene.2021.145968
433.
Mei SL, Xia ZY, Qiu Z, Jia YF, Zhou JJ, Zhou B. Shenmai injection attenuates myocardial ischemia/reperfusion injury by targeting Nrf2/GPX4 signalling-mediated ferroptosis. Chin J Integr Med. 2022;28(11):983-991.
Not in our library10.1007/s11655-022-3620-x
434.
Zhang F, Li Z, Gao P, Zou J, Cui Y, Qian Y, et al. HJ11 decoction restrains development of myocardial ischemia-reperfusion injury in rats by suppressing ACSL4-mediated ferroptosis. Front Pharmacol. 2022;13:1024292.
Not in our library10.3389/fphar.2022.1024292
435.
Ding Y, Li W, Peng S, Zhou G, Chen S, Wei Y, et al. Puerarin protects against myocardial ischemia/reperfusion injury by inhibiting ferroptosis. Biol Pharm Bull. 2023;46(4):524-532.
Not in our library10.1248/bpb.b22-00174
436.
Guo L, Shi L. Vitexin Improves Cerebral ischemia-reperfusion Injury by Attenuating Oxidative Injury and Ferroptosis via Keap1/Nrf2/HO-1signaling. Neurochem Res. 2023;48(3):980-995.
Not in our library10.1007/s11064-022-03829-0
437.
Liu J, Zhou Y, Xie C, Li C, Ma L, Zhang Y. Anti-Ferroptotic Effects of bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Loaded with Ferrostatin-1 in Cerebral ischemia-reperfusion Injury Associate with the GPX4/COX-2 Axis. Neurochem Res. 2023;48(2):502-518.
Not in our library10.1007/s11064-022-03770-2
438.
Zhao J, Ma M, Li L, Fang G. Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis. Mol Med Rep. 2023;27(2). 10.3892/mmr.2023.12931.
Not in our library10.3892/mmr.2023.12931
439.
Tuo Q-Z, Masaldan S, Southon A, Mawal C, Ayton S, Bush AI, et al. Characterization of selenium compounds for anti-ferroptotic activity in neuronal cells and after cerebral ischemia-reperfusion injury. Neurotherapeutics. 2021;18(4):2682-2691.
Not in our library10.1007/s13311-021-01111-9
440.
Shi Y, Han L, Zhang X, Xie L, Pan P, Chen F. Selenium alleviates cerebral ischemia/reperfusion injury by regulating oxidative stress, mitochondrial fusion and ferroptosis. Neurochem Res. 2022;47(10):2992-3002.
Not in our library10.1007/s11064-022-03643-8
441.
Guan X, Li X, Yang X, Yan J, Shi P, Ba L, et al. The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation. Life Sci. 2019;235:116795.
Not in our library10.1016/j.lfs.2019.116795
442.
Fu C, Wu Y, Liu S, Luo C, Lu Y, Liu M, et al. Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia. J Ethnopharmacol. 2022;289:115021.
Not in our library10.1016/j.jep.2022.115021
443.
Guan X, Li Z, Zhu S, Cheng M, Ju Y, Ren L, et al. Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils. Life Sci. 2021;264:118660.
Not in our library10.1016/j.lfs.2020.118660
444.
Guo H, Zhu L, Tang P, Chen D, Li Y, Li J et al. Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats. Int J Mol Med. 2021;47(4). 10.3892/ijmm.2021.4885.
Not in our library10.3892/ijmm.2021.4885
445.
Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis · 2021
No notice
446.
Feng Y, Madungwe NB, Imam Aliagan AD, Tombo N, Bopassa JC. Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels. Biochem Biophys Res Commun. 2019;520(3):606-611.
Not in our library10.1016/j.bbrc.2019.10.006
447.
Xu Y, Li X, Cheng Y, Yang M, Wang R. Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia-reperfusion. FASEB J. 2020;34(12):16262-16275.
Not in our library10.1096/fj.202001758r
448.
Yamada N, Karasawa T, Wakiya T, Sadatomo A, Ito H, Kamata R, et al. Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: Potential role of ferroptosis. Am J Transplant. 2020;20(6):1606-1618.
Not in our library10.1111/ajt.15773
449.
Ma L, Liu X, Zhang M, Zhou L, Jiang L, Gao L, et al. Paeoniflorin alleviates ischemia/reperfusion induced acute kidney injury by inhibiting Slc7a11-mediated ferroptosis. Int Immunopharmacol. 2023;116:109754.
Not in our library10.1016/j.intimp.2023.109754
450.
Kar F, Yildiz F, Hacioglu C, Kar E, Donmez DB, Senturk H, et al. LoxBlock-1 or Curcumin attenuates liver, pancreas and cardiac ferroptosis, oxidative stress and injury in Ischemia/reperfusion-damaged rats by facilitating ACSL/GPx4 signaling. Tissue Cell. 2023;82:102114.
Not in our library10.1016/j.tice.2023.102114
451.
Kolbrink B, von Samson-Himmelstjerna FA, Messtorff ML, Riebeling T, Nische R, Schmitz J, et al. Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury. Cell Mol Life Sci. 2022;79(7):387.
Not in our library10.1007/s00018-022-04416-w
452.
Jiang GP, Liao YJ, Huang LL, Zeng XJ, Liao XH. Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injury. Mol Med Rep. 2021;23(1). 10.3892/mmr.2020.11704.
Not in our library10.3892/mmr.2020.11704
453.
Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, et al. Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A. 2014;111(47):16836-16841.
Not in our library10.1073/pnas.1415518111
454.
XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury · 2020
No notice
455.
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury · 2021
No notice
456.
Yang J, Sun X, Huang N, Li P, He J, Jiang L, et al. Entacapone alleviates acute kidney injury by inhibiting ferroptosis. FASEB J. 2022;36(7):e22399.
Not in our library10.1096/fj.202200241rr
457.
Wang Y, Chen Z, Luo J, Zhang J, Sang AM, Cheng ZS, et al. Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis. Int Immunopharmacol. 2023;115:109731.
Not in our library10.1016/j.intimp.2023.109731
458.
Zhongyin Z, Wei W, Juan X, Guohua F. Isoliquiritin apioside relieves intestinal ischemia/reperfusion-induced acute lung injury by blocking Hif-1alpha-mediated ferroptosis. Int Immunopharmacol. 2022;108:108852.
Not in our library10.1016/j.intimp.2022.108852
459.
Ma X, Yan W, He N. Lidocaine attenuates hypoxia/reoxygenation‑induced inflammation, apoptosis and ferroptosis in lung epithelial cells by regulating the p38 MAPK pathway. Mol Med Rep. 2022;25(5). 10.3892/mmr.2022.12666.
Not in our library10.3892/mmr.2022.12666
460.
Chen K, Xu Z, Liu Y, Wang Z, Li Y, Xu X et al. Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury. Sci Transl Med. 2017;9(418). 10.1126/scitranslmed.aao6298.
Not in our library10.1126/scitranslmed.aao6298
461.
Zhang J, Bi J, Ren Y, Du Z, Li T, Wang T, et al. Involvement of GPX4 in irisin's protection against ischemia reperfusion-induced acute kidney injury. J Cell Physiol. 2021;236(2):931-945.
Not in our library10.1002/jcp.29903
462.
Kang Y, Tiziani S, Park G, Kaul M, Paternostro G. Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity. Nat Commun. 2014;5:3672.
Not in our library10.1038/ncomms4672
463.
Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, et al. The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress. Cell Death Dis. 2013;4(1):e470.
Not in our library10.1038/cddis.2012.216
464.
Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16(12):1180-1191.
Not in our library10.1038/ncb3064
465.
Bartzokis G, Tishler TA, Shin I-S, Lu PH, Cummings JL. Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases. Ann N Y Acad Sci. 2004;1012:224-236.
Not in our library10.1196/annals.1306.019
466.
Connor JR, Menzies SL, St Martin SM, Mufson EJ. A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J Neurosci Res. 1992;31(1):75-83.
Not in our library10.1002/jnr.490310111
467.
Jellinger K, Paulus W, Grundke-Iqbal I, Riederer P, Youdim MB. Brain iron and ferritin in Parkinson's and Alzheimer's diseases. J Neural Transm Park Dis Dement Sect. 1990;2(4):327-340.
Not in our library10.1007/bf02252926
468.
Quintana C, Bellefqih S, Laval JY, Guerquin-Kern JL, Wu TD, Avila J, et al. Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J Struct Biol. 2006;153(1):42-54.
Not in our library10.1016/j.jsb.2005.11.001
469.
Belaidi AA, Masaldan S, Southon A, Kalinowski P, Acevedo K, Appukuttan AT, et al. Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy. Mol Psychiatry. 2022.
Not in our library10.1038/s41380-022-01568-w
470.
Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE · 2015
No notice
471.
Wu Y, Torabi S-F, Lake RJ, Hong S, Yu Z, Wu P, et al. Simultaneous Fe2+/Fe3+ imaging shows Fe3+ over Fe2+ enrichment in Alzheimer's disease mouse brain. Sci Adv. 2023;9(16):eade7622.
Not in our library10.1126/sciadv.ade7622
472.
Greenough MA, Lane DJR, Balez R, Anastacio HTD, Zeng Z, Ganio K, et al. Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations. Cell Death Differ. 2022;29(11):2123-2136.
Not in our library10.1038/s41418-022-01003-1
473.
Zhu Z-Y, Liu Y-D, Gong Y, Jin W, Topchiy E, Turdi S, et al. Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis. Acta Pharmacol Sin. 2022;43(1):39-49.
Not in our library10.1038/s41401-021-00635-2
474.
Chen L, Dar NJ, Na R, McLane KD, Yoo K, Han X et al. Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice. Free Radic Biol Med. 2022;180. 10.1016/j.freeradbiomed.2022.01.002.
Not in our library10.1016/j.freeradbiomed.2022.01.002
475.
Park MW, Cha HW, Kim J, Kim JH, Yang H, Yoon S, et al. NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases. Redox Biol. 2021;41:101947.
Not in our library10.1016/j.redox.2021.101947
476.
Wang S, Jiang Y, Liu Y, Liu Q, Sun H, Mei M, et al. Ferroptosis promotes microtubule-associated protein tau aggregation via GSK-3β activation and proteasome inhibition. Mol Neurobiol. 2022;59(3):1486-1501.
Not in our library10.1007/s12035-022-02731-8
477.
Sun J, Lin X-M, Lu D-H, Wang M, Li K, Li S-R et al. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. J Clin Invest. 2023;133(10). 10.1172/JCI165228.
Not in our library10.1172/jci165228
478.
Bouchaoui H, Mahoney-Sanchez L, Garçon G, Berdeaux O, Alleman LY, Devos D, et al. ACSL4 and the lipoxygenases 15/15B are pivotal for ferroptosis induced by iron and PUFA dyshomeostasis in dopaminergic neurons. Free Radic Biol Med. 2023;195:145-157.
Not in our library10.1016/j.freeradbiomed.2022.12.086
479.
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration · 2022
No notice
480.
Oun A, Soliman A, Trombetta-Lima M, Tzepapadaki A, Tsagkari D, Kortholt A, et al. LRRK2 protects immune cells against erastin-induced ferroptosis. Neurobiol Dis. 2022;175:105917.
Not in our library10.1016/j.nbd.2022.105917
481.
Mahoney-Sanchez L, Bouchaoui H, Boussaad I, Jonneaux A, Timmerman K, Berdeaux O, et al. Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition. Cell Rep. 2022;40(8):111231.
Not in our library10.1016/j.celrep.2022.111231
482.
Huang Z, Han J, Wu P, Wu C, Fan Y, Zhao L, et al. Sorting nexin 5 plays an important role in promoting ferroptosis in Parkinson's Disease. Oxid Med Cell Longev. 2022;2022:5463134.
Not in our library10.1155/2022/5463134
483.
Lee WJ, Lee HG, Hur J, Lee GH, Won JP, Kim E et al. PPARδ activation mitigates 6-OHDA-induced neuronal damage by regulating intracellular iron levels. Antioxidants (Basel). 2022;11(5). 10.3390/antiox11050810.
Not in our library10.3390/antiox11050810
484.
Han K, Jin X, Guo X, Cao G, Tian S, Song Y, et al. Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice. Free Radic Biol Med. 2021;162:592-602.
Not in our library10.1016/j.freeradbiomed.2020.11.019
485.
Kambey PA, Liu W-Y, Wu J, Bosco B, Nadeem I, Kanwore K, et al. Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect. Neural Regen Res. 2023;18(9):2037-2046.
Not in our library10.4103/1673-5374.366493
486.
Zhang N, Yu X, Song L, Xiao Z, Xie J, Xu H. Ferritin confers protection against iron-mediated neurotoxicity and ferroptosis through iron chelating mechanisms in MPP(+)-induced MES23.5 dopaminergic cells. Free Radic Biol Med. 2022;193(Pt 2):751-63.
Not in our library10.1016/j.freeradbiomed.2022.11.018
487.
Bai L, Yan F, Deng R, Gu R, Zhang X, Bai J. Thioredoxin-1 rescues MPP+/MPTP-induced ferroptosis by increasing glutathione peroxidase 4. Mol Neurobiol. 2021;58(7):3187-3197.
Not in our library10.1007/s12035-021-02320-1
488.
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1 · 2022
No notice
489.
Wang T, Tomas D, Perera ND, Cuic B, Luikinga S, Viden A, et al. Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis. Cell Death Differ. 2022;29(6):1187-1198.
Not in our library10.1038/s41418-021-00910-z
490.
Peng J, Pan J, Mo J, Peng Y. MPO/HOCl facilitates apoptosis and ferroptosis in the SOD1G93A motor neuron of Amyotrophic Lateral Sclerosis. Oxid Med Cell Longev. 2022;2022:8217663.
Not in our library10.1155/2022/8217663
491.
Song S, Su Z, Kon N, Chu B, Li H, Jiang X, et al. ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease. Genes Dev. 2023;37(5–6):204-217.
Not in our library10.1101/gad.350211.122
492.
Ralhan I, Chang J, Moulton MJ, Goodman LD, Lee NYJ, Plummer G et al. Autolysosomal exocytosis of lipids protect neurons from ferroptosis. J Cell Biol. 2023;222(6). 10.1083/jcb.202207130.
Not in our library10.1083/jcb.202207130
493.
Massive iron accumulation in PKAN-derived neurons and astrocytes: light on the human pathological phenotype · 2022
Not checked
494.
Musheshe N, Oun A, Sabogal-Guáqueta AM, Trombetta-Lima M, Mitchel SC, Adzemovic A et al. Pharmacological inhibition of epac1 averts ferroptosis cell death by preserving mitochondrial integrity. Antioxidants (Basel, Switzerland). 2022;11(2). 10.3390/antiox11020314.
Not in our library10.3390/antiox11020314
495.
Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death · 2021
Not checked
496.
Fernández-Mendívil C, Luengo E, Trigo-Alonso P, García-Magro N, Negredo P, López MG. Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. Redox Biol. 2021;38:101789.
Not in our library10.1016/j.redox.2020.101789
497.
Diaw SH, Ganos C, Zittel S, Plötze-Martin K, Kulikovskaja L, Vos M et al. Mutant WDR45 leads to altered ferritinophagy and ferroptosis in β-propeller protein-associated neurodegeneration. Int J Mol Sci. 2022;23(17). 10.3390/ijms23179524.
Not in our library10.3390/ijms23179524
498.
Zhang H, Zhou W, Li J, Qiu Z, Wang X, Xu H, et al. Senegenin rescues PC12 cells with oxidative damage through inhibition of ferroptosis. Mol Neurobiol. 2022;59(11):6983-6992.
Not in our library10.1007/s12035-022-03014-y
499.
Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation · 2022
No notice
500.
Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation · 2022
No notice
501.
Liu Y, Han C, Dai R, Li B. Rational design, synthesis and activities of hydroxylated chalcones as highly potent dual functional agents against Alzheimer's disease. Bioorg Chem. 2022;122:105662.
Not in our library10.1016/j.bioorg.2022.105662
502.
Yang S, Wang L, Zeng Y, Wang Y, Pei T, Xie Z, et al. Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice. Phytomedicine. 2023;114:154762.
Not in our library10.1016/j.phymed.2023.154762
503.
Gao Y, Li J, Wu Q, Wang S, Yang S, Li X, et al. Tetrahydroxy stilbene glycoside ameliorates Alzheimer's disease in APP/PS1 mice via glutathione peroxidase related ferroptosis. Int Immunopharmacol. 2021;99:108002.
Not in our library10.1016/j.intimp.2021.108002
504.
Quercetin Protects against MPP + /MPTP‐Induced Dopaminergic Neuron Death in Parkinson’s Disease by Inhibiting Ferroptosis · 2022
No notice
505.
Li K, Wang M, Huang Z-H, Wang M, Sun W-Y, Kurihara H et al. ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis. Pharmacol Res. 2023:106779. 10.1016/j.phrs.2023.106779.
Not in our library10.1016/j.phrs.2023.106779
506.
Xi J, Zhang Z, Wang Z, Wu Q, He Y, Xu Y, et al. Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection. Free Radic Biol Med. 2022;190:202-215.
Not in our library10.1016/j.freeradbiomed.2022.08.011
507.
Sun W-Y, Tyurin VA, Mikulska-Ruminska K, Shrivastava IH, Anthonymuthu TS, Zhai Y-J, et al. Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal. Nat Chem Biol. 2021;17(4):465-476.
Not in our library10.1038/s41589-020-00734-x
508.
Cao Z, Wang X, Zhang T, Fu X, Zhang F, Zhu J. Discovery of novel 2-(4-(benzyloxy)-5-(hydroxyl) phenyl) benzothiazole derivatives as multifunctional MAO-B inhibitors for the treatment of Parkinson's disease. J Enzyme Inhib Med Chem. 2023;38(1):2159957.
Not in our library10.1080/14756366.2022.2159957
509.
Shen Z-B, Meng H-W, Meng X-S, Lv Z-K, Fang M-Y, Zhang L-L, et al. Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease. Eur J Med Chem. 2023;255:115417.
Not in our library10.1016/j.ejmech.2023.115417
510.
Sun Y, He L, Wang W, Xie Z, Zhang X, Wang P, et al. Activation of Atg7-dependent autophagy by a novel inhibitor of the Keap1-Nrf2 protein-protein interaction from Penthorum chinense Pursh. attenuates 6-hydroxydopamine-induced ferroptosis in zebrafish and dopaminergic neurons. Food Funct. 2022;13(14):7885-900.
Not in our library10.1039/d2fo00357k
511.
Liang Z, Soriano-Castell D, Kepchia D, Duggan BM, Currais A, Schubert D, et al. Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors. Free Radic Biol Med. 2022;180:33-51.
Not in our library10.1016/j.freeradbiomed.2022.01.001
512.
Tang W, Li Y, He S, Jiang T, Wang N, Du M, et al. Caveolin-1 alleviates diabetes-associated cognitive dysfunction through modulating neuronal ferroptosis-mediated mitochondrial homeostasis. Antioxid Redox Signal. 2022;37(13–15):867-886.
Not in our library10.1089/ars.2021.0233
513.
Li Y, Sun M, Cao F, Chen Y, Zhang L, Li H et al. The ferroptosis inhibitor liproxstatin-1 ameliorates LPS-induced cognitive impairment in mice. Nutrients. 2022;14(21). 10.3390/nu14214599.
Not in our library10.3390/nu14214599
514.
Knopman DS, Amieva H, Petersen RC, Chetelat G, Holtzman DM, Hyman BT, et al. Alzheimer disease. Nat Rev Dis Primers. 2021;7(1):33.
Not in our library10.1038/s41572-021-00269-y
515.
Ayton S, Wang Y, Diouf I, Schneider JA, Brockman J, Morris MC, et al. Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology. Mol Psychiatry. 2020;25(11):2932-2941.
Not in our library10.1038/s41380-019-0375-7
516.
Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death · 2020
No notice
517.
Yang Y, Wang X, Xiao A, Han J, Wang Z, Wen M. Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer's disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1/Nrf2 pathway. Front Aging Neurosci. 2022;14:998292.
Not in our library10.3389/fnagi.2022.998292
518.
Feng J, Song G, Wu Y, Chen X, Pang J, Xu Y, et al. Plasmalogens improve swimming performance by modulating the expression of genes involved in amino acid and lipid metabolism, oxidative stress, and ferroptosis in an Alzheimer's disease zebrafish model. Food Funct. 2021;12(23):12087-12097.
Not in our library10.1039/d1fo01471d
519.
Faucheux BA, Martin M-E, Beaumont C, Hunot S, Hauw J-J, Agid Y, et al. Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease. J Neurochem. 2002;83(2):320-330.
Not in our library10.1046/j.1471-4159.2002.01118.x
520.
Ayton S, Lei P, Duce JA, Wong BXW, Sedjahtera A, Adlard PA, et al. Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease. Ann Neurol. 2013;73(4):554-559.
Not in our library10.1002/ana.23817
521.
Bi M, Du X, Jiao Q, Liu Z, Jiang H. α-synuclein regulates iron homeostasis via preventing Parkin-mediated DMT1 ubiquitylation in Parkinson's Disease models. ACS Chem Neurosci. 2020;11(11):1682-1691.
Not in our library10.1021/acschemneuro.0c00196
522.
Zhang Y, Li S, Hou L, Wu M, Liu J, Wang R, et al. NLRP3 mediates the neuroprotective effects of SVHRSP derived from scorpion venom in rotenone-induced experimental Parkinson's disease model. J Ethnopharmacol. 2023;312:116497.
Not in our library10.1016/j.jep.2023.116497
523.
Desouky MA, George MY, Michel HE, Elsherbiny DA. Roflumilast escalates α-synuclein aggregate degradation in rotenone-induced Parkinson's disease in rats: Modulation of the ubiquitin-proteasome system and endoplasmic reticulum stress. Chem Biol Interact. 2023;379:110491.
Not in our library10.1016/j.cbi.2023.110491
524.
Masrori P, Van Damme P. Amyotrophic lateral sclerosis: a clinical review. Eur J Neurol. 2020;27(10):1918-1929.
Not in our library10.1111/ene.14393
525.
Akçimen F, Lopez ER, Landers JE, Nath A, Chiò A, Chia R, et al. Amyotrophic lateral sclerosis: translating genetic discoveries into therapies. Nat Rev Genet. 2023.
Not in our library10.1038/s41576-023-00592-y
526.
Matsuo T, Adachi-Tominari K, Sano O, Kamei T, Nogami M, Ogi K, et al. Involvement of ferroptosis in human motor neuron cell death. Biochem Biophys Res Commun. 2021;566:24-29.
Not in our library10.1016/j.bbrc.2021.05.095
527.
Moreau C, Danel V, Devedjian JC, Grolez G, Timmerman K, Laloux C, et al. Could conservative iron chelation lead to neuroprotection in amyotrophic lateral sclerosis? Antioxid Redox Signal. 2018;29(8):742-748.
Not in our library10.1089/ars.2017.7493
528.
Tabrizi SJ, Flower MD, Ross CA, Wild EJ. Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities. Nat Rev Neurol. 2020;16(10):529-546.
Not in our library10.1038/s41582-020-0389-4
529.
Klepac N, Relja M, Klepac R, Hećimović S, Babić T, Trkulja V. Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects: a cross-sectional study. J Neurol. 2007;254(12):1676-1683.
Not in our library10.1007/s00415-007-0611-y
530.
Rosas HD, Chen YI, Doros G, Salat DH, Chen N-K, Kwong KK, et al. Alterations in brain transition metals in Huntington disease: an evolving and intricate story. Arch Neurol. 2012;69(7):887-93.
Not in our library10.1001/archneurol.2011.2945
531.
Trend analysis of cardiovascular disease mortality, incidence, and mortality-to-incidence ratio: results from global burden of disease study 2017 · 2021
No notice
532.
Wang K, Chen XZ, Wang YH, Cheng XL, Zhao Y, Zhou LY, et al. Emerging roles of ferroptosis in cardiovascular diseases. Cell Death Discov. 2022;8(1):394.
Not in our library10.1038/s41420-022-01183-2
533.
Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation · 2022
No notice
534.
Wang R, Xu Y, Fang Y, Wang C, Xue Y, Wang F, et al. Pathogenetic mechanisms of septic cardiomyopathy. J Cell Physiol. 2022;237(1):49-58.
Not in our library10.1002/jcp.30527
535.
Izzy M, Oh J, Watt KD. Cirrhotic cardiomyopathy after transplantation: neither the transient nor innocent bystander. Hepatology. 2018;68(5):2008-2015.
Not in our library10.1002/hep.30040
536.
Maron BJ, Maron MS. Hypertrophic cardiomyopathy. Lancet. 2013;381(9862):242-255.
Not in our library10.1016/s0140-6736(12)60397-3
537.
Wang Y, Lu Y, Chen W, Xie X. Inhibition of ferroptosis alleviates high-power microwave-induced myocardial injury. Front Cardiovasc Med. 2023;10:1157752.
Not in our library10.3389/fcvm.2023.1157752
538.
Liu F, Jiang LJ, Zhang YX, Xu ST, Liu SL, Ye JT, et al. Inhibition of miR-214-3p attenuates ferroptosis in myocardial infarction via regulating ME2. Biochem Biophys Res Commun. 2023;661:64-74.
Not in our library10.1016/j.bbrc.2023.04.031
539.
Jiang Y, Qiao Y, He D, Tian A, Li Z. Adaptor protein HIP-55-mediated signalosome protects against ferroptosis in myocardial infarction. Cell Death Differ. 2023;30(3):825-838.
Not in our library10.1038/s41418-022-01110-z
540.
Cao G, Yang C, Jin Z, Wei H, Xin C, Zheng C, et al. FNDC5/irisin reduces ferroptosis and improves mitochondrial dysfunction in hypoxic cardiomyocytes by Nrf2/HO-1 axis. Cell Biol Int. 2022;46(5):723-736.
Not in our library10.1002/cbin.11763
541.
Gao F, Zhao Y, Zhang B, Xiao C, Sun Z, Gao Y, et al. Suppression of lncRNA Gm47283 attenuates myocardial infarction via miR-706/ Ptgs2/ferroptosis axis. Bioengineered. 2022;13(4):10786-10802.
Not in our library10.1080/21655979.2022.2065743
542.
Wu Y, Huang T, Li X, Shen C, Ren H, Wang H, et al. Retinol dehydrogenase 10 reduction mediated retinol metabolism disorder promotes diabetic cardiomyopathy in male mice. Nat Commun. 2023;14(1):1181.
Not in our library10.1038/s41467-023-36837-x
543.
Zhang J, Qiu Q, Wang H, Chen C, Luo D. TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination. Exp Cell Res. 2021;407(2):112800.
Not in our library10.1016/j.yexcr.2021.112800
544.
Wang N, Ma H, Li J, Meng C, Zou J, Wang H, et al. HSF1 functions as a key defender against palmitic acid-induced ferroptosis in cardiomyocytes. J Mol Cell Cardiol. 2021;150:65-76.
Not in our library10.1016/j.yjmcc.2020.10.010
545.
Wang X, Chen X, Zhou W, Men H, Bao T, Sun Y, et al. Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways. Acta Pharm Sin B. 2022;12(2):708-722.
Not in our library10.1016/j.apsb.2021.10.005
546.
Chen L, Yin Z, Qin X, Zhu X, Chen X, Ding G, et al. CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis. Pharmacol Res. 2022;176:106086.
Not in our library10.1016/j.phrs.2022.106086
547.
Leng B, Deng L, Tan J, Lee WT, Cao CR, Wang ZP, et al. Targeting the Na(+)/K(+) ATPase DR-region with DR-Ab improves doxorubicin-induced cardiotoxicity. Free Radic Biol Med. 2023;204:38-53.
Not in our library10.1016/j.freeradbiomed.2023.04.008
548.
Wang Y, Yan S, Liu X, Deng F, Wang P, Yang L, et al. PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway. Cell Death Differ. 2022;29(10):1982-1995.
Not in our library10.1038/s41418-022-00990-5
549.
Ta N, Qu C, Wu H, Zhang D, Sun T, Li Y, et al. Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy. Proc Natl Acad Sci U S A. 2022;119(36):e2117396119.
Not in our library10.1073/pnas.2117396119
550.
Wang AJ, Tang Y, Zhang J, Wang BJ, Xiao M, Lu G, et al. Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2. Redox Biol. 2022;52:102310.
Not in our library10.1016/j.redox.2022.102310
551.
Kawano I, Adamcova M. MicroRNAs in doxorubicin-induced cardiotoxicity: the DNA damage response. Front Pharmacol. 2022;13:1055911.
Not in our library10.3389/fphar.2022.1055911
552.
Pan J, Xiong W, Zhang A, Zhang H, Lin H, Gao L, et al. The imbalance of p53-Park7 signaling axis induces iron homeostasis dysfunction in doxorubicin-challenged cardiomyocytes. Adv Sci (Weinh). 2023;10(15):e2206007.
Not in our library10.1002/advs.202206007
553.
Yu Y, Wu T, Lu Y, Zhao W, Zhang J, Chen Q, et al. Exosomal thioredoxin-1 from hypoxic human umbilical cord mesenchymal stem cells inhibits ferroptosis in doxorubicin-induced cardiotoxicity via mTORC1 signaling. Free Radic Biol Med. 2022;193(Pt 1):108-121.
Not in our library10.1016/j.freeradbiomed.2022.10.268
554.
Hu C, Zhang X, Song P, Yuan YP, Kong CY, Wu HM, et al. Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway. Redox Biol. 2020;37:101747.
Not in our library10.1016/j.redox.2020.101747
555.
Wu X, Wang L, Wang K, Li J, Chen R, Wu X, et al. ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity. Mol Ther. 2022;30(1):400-414.
Not in our library10.1016/j.ymthe.2021.07.004
556.
Yu W, Chen C, Xu C, Xie D, Wang Q, Liu W, et al. Activation of p62-NRF2 axis protects against doxorubicin-induced ferroptosis in cardiomyocytes: a novel Role and molecular mechanism of resveratrol. Am J Chin Med. 2022;50(8):2103-2123.
Not in our library10.1142/s0192415x22500902
557.
Peng H, Fu S, Wang S, Xu H, Dhanasekaran M, Chen H, et al. Ablation of FUNDC1-dependent mitophagy renders myocardium resistant to paraquat-induced ferroptosis and contractile dysfunction. Biochim Biophys Acta Mol Basis Dis. 2022;1868(9):166448.
Not in our library10.1016/j.bbadis.2022.166448
558.
Kong C, Ni X, Wang Y, Zhang A, Zhang Y, Lin F, et al. ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking. Cell Death Dis. 2022;8(1):187.
Not in our library10.1038/s41420-022-00957-y
559.
Chen Z, Cao Z, Gui F, Zhang M, Wu X, Peng H et al. TMEM43 protects against sepsis-induced cardiac injury via inhibiting ferroptosis in mice. Cells. 2022;11(19). 10.3390/cells11192992.
Not in our library10.3390/cells11192992
560.
Shen H, Xie K, Tian Y, Wang X. N6-methyladenosine writer METTL3 accelerates the sepsis-induced myocardial injury by regulating m6A-dependent ferroptosis. Apoptosis. 2023;28(3–4):514-524.
Not in our library10.1007/s10495-022-01808-y
561.
Wang JX, Zhao Y, Chen MS, Zhang H, Cui JG, Li JL. Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis. Environ Pollut. 2023;317:120717.
Not in our library10.1016/j.envpol.2022.120717
562.
Chen D, Geng Y, Deng Z, Li P, Xue S, Xu T et al. Inhibition of TLR4 alleviates heat stroke-Induced cardiomyocyte injury by down-regulating inflammation and ferroptosis. Molecules. 2023;28(5). 10.3390/molecules28052297.
Not in our library10.3390/molecules28052297
563.
Zhang X, Zheng C, Gao Z, Chen H, Li K, Wang L, et al. SLC7A11/xCT prevents cardiac hypertrophy by inhibiting ferroptosis. Cardiovasc Drugs Ther. 2022;36(3):437-447.
Not in our library10.1007/s10557-021-07220-z
564.
Ahola S, Rivera Mejías P, Hermans S, Chandragiri S, Giavalisco P, Nolte H, et al. OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. Cell Metab. 2022;34(11):1875-91.e7.
Not in our library10.1016/j.cmet.2022.08.017
565.
Liao J, Xie SS, Deng Y, Wu DD, Meng H, Lan WF, et al. PRDX6-mediated pulmonary artery endothelial cell ferroptosis contributes to monocrotaline-induced pulmonary hypertension. Microvasc Res. 2023;146:104471.
Not in our library10.1016/j.mvr.2022.104471
566.
Li H, Ding J, Liu W, Wang X, Feng Y, Guan H, et al. Plasma exosomes from patients with acute myocardial infarction alleviate myocardial injury by inhibiting ferroptosis through miR-26b-5p/SLC7A11 axis. Life Sci. 2023;322:121649.
Not in our library10.1016/j.lfs.2023.121649
567.
Li D, Zhang G, Wang Z, Guo J, Liu Y, Lu Y, et al. Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction. Eur J Pharmacol. 2023;943:175569.
Not in our library10.1016/j.ejphar.2023.175569
568.
Curcumin Attenuates Ferroptosis-Induced Myocardial Injury in Diabetic Cardiomyopathy through the Nrf2 Pathway · 2022
Not checked
569.
Chen Y, Li S, Yin M, Li Y, Chen C, Zhang J, et al. Isorhapontigenin attenuates cardiac microvascular injury in diabetes via the inhibition of mitochondria-associated ferroptosis through PRDX2-MFN2-ACSL4 pathways. Diabetes. 2023;72(3):389-404.
Not in our library10.2337/db22-0553
570.
Xu C, Ou E, Li Z, Chen Z, Jia Q, Xu X, et al. Synthesis and in vivo evaluation of new steviol derivatives that protect against cardiomyopathy by inhibiting ferroptosis. Bioorg Chem. 2022;129:106142.
Not in our library10.1016/j.bioorg.2022.106142
571.
Tadokoro T, Ikeda M, Abe K, Ide T, Miyamoto HD, Furusawa S, et al. Ethoxyquin is a competent radical-trapping antioxidant for preventing ferroptosis in doxorubicin cardiotoxicity. J Cardiovasc Pharmacol. 2022;80(5):690-699.
Not in our library10.1097/fjc.0000000000001328
572.
Zhu X, Wang X, Zhu B, Ding S, Shi H, Yang X. Disruption of histamine/H(1)R-STAT3-SLC7A11 axis exacerbates doxorubicin-induced cardiac ferroptosis. Free Radic Biol Med. 2022;192:98-114.
Not in our library10.1016/j.freeradbiomed.2022.09.012
573.
Luo LF, Guan P, Qin LY, Wang JX, Wang N, Ji ES. Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling. Mol Cell Biochem. 2021;476(7):2603-2611.
Not in our library10.1007/s11010-021-04112-6
574.
Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Furusawa S, et al. Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis. Sci Signal. 2022;15(758):eabn8017.
Not in our library10.1126/scisignal.abn8017
575.
Zhang Y, Liu S, Peng J, Cheng S, Zhang Q, Zhang N et al. Biomimetic nanozymes suppressed ferroptosis to ameliorate doxorubicin-induced cardiotoxicity via synergetic effect of antioxidant stress and GPX4 restoration. Nutrients. 2023;15(5). 10.3390/nu15051090.
Not in our library10.3390/nu15051090
576.
Liu X, Li D, Pi W, Wang B, Xu S, Yu L, et al. LCZ696 protects against doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via AKT/SIRT3/SOD2 signaling pathway activation. Int Immunopharmacol. 2022;113(Pt A):109379.
Not in our library10.1016/j.intimp.2022.109379
577.
Wang M, Liu M, Tang L, Shen L, Xiao J, Li R. Liquiritin reduces ferroptosis in doxorubicin-induced cardiotoxicity through targeting SLC7A11/GPX4 pathway. Naunyn Schmiedebergs Arch Pharmacol. 2023. 10.1007/s00210-023-02515-4.
Not in our library10.1007/s00210-023-02515-4
578.
Sun L, Wang H, Xu D, Yu S, Zhang L, Li X. Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K/AKT signaling pathway. Bioengineered. 2022;13(1):48-60.
Not in our library10.1080/21655979.2021.2004980
579.
Cheah IK, Tang RMY, Wang X, Sachaphibulkij K, Chong SY, Lim LHK et al. Protection against doxorubicin-induced cardiotoxicity by ergothioneine. Antioxidants. 2023;12(2). 10.3390/antiox12020320.
Not in our library10.3390/antiox12020320
580.
Chen H, Zhu J, Le Y, Pan J, Liu Y, Liu Z, et al. Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway. Phytomedicine. 2022;99:153964.
Not in our library10.1016/j.phymed.2022.153964
581.
He H, Wang L, Qiao Y, Yang B, Yin D, He M. Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy. Redox Biol. 2021;48:102185.
Not in our library10.1016/j.redox.2021.102185
582.
Shubhra QTH, Guo K, Liu Y, Razzak M, Serajum Manir M, Moshiul Alam AKM. Dual targeting smart drug delivery system for multimodal synergistic combination cancer therapy with reduced cardiotoxicity. Acta Biomater. 2021;131:493-507.
Not in our library10.1016/j.actbio.2021.06.016
583.
Fu X, Eggert M, Yoo S, Patel N, Zhong J, Steinke I, et al. The cardioprotective mechanism of phenylaminoethyl selenides (PAESe) against doxorubicin-induced cardiotoxicity involves frataxin. Front Pharmacol. 2020;11:574656.
Not in our library10.3389/fphar.2020.574656
584.
Song C, Li D, Zhang J, Zhao X. Berberine hydrochloride alleviates imatinib mesylate - induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis. Food Funct. 2023;14(2):1087-1098.
Not in our library10.1039/d2fo03331c
585.
Ma S, He LL, Zhang GR, Zuo QJ, Wang ZL, Zhai JL, et al. Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction. Naunyn Schmiedebergs Arch Pharmacol. 2022;395(8):945-962.
Not in our library10.1007/s00210-022-02243-1
586.
Zhang W, Lu J, Wang Y, Sun P, Gao T, Xu N et al. Canagliflozin attenuates lipotoxicity in cardiomyocytes by inhibiting inflammation and ferroptosis through activating AMPK pathway. Int J Mol Sci. 2023;24(1). 10.3390/ijms24010858.
Not in our library10.3390/ijms24010858
587.
Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus · 2021
No notice
588.
Li D, Song C, Zhang J, Zhao X. Resveratrol alleviated 5-FU-induced cardiotoxicity by attenuating GPX4 dependent ferroptosis. J Nutr Biochem. 2023;112:109241.
Not in our library10.1016/j.jnutbio.2022.109241
589.
Wang X, Simayi A, Fu J, Zhao X, Xu G. Resveratrol mediates the miR-149/HMGB1 axis and regulates the ferroptosis pathway to protect myocardium in endotoxemia mice. Am J Physiol Endocrinol Metab. 2022;323(1):E21-e32.
Not in our library10.1152/ajpendo.00227.2021
590.
Min J, Wu L, Liu Y, Song G, Deng Q, Jin W, et al. Empagliflozin attenuates trastuzumab-induced cardiotoxicity through suppression of DNA damage and ferroptosis. Life Sci. 2023;312:121207.
Not in our library10.1016/j.lfs.2022.121207
591.
Bian J, Ding Y, Wang S, Jiang Y, Wang M, Wei K, et al. Celastrol confers ferroptosis resistance via AKT/GSK3β signaling in high-fat diet-induced cardiac injury. Free Radic Biol Med. 2023;200:36-46.
Not in our library10.1016/j.freeradbiomed.2023.03.004
592.
Liu T, Shu J, Liu Y, Xie J, Li T, Li H, et al. Atorvastatin attenuates ferroptosis-dependent myocardial injury and inflammation following coronary microembolization via the Hif1a/Ptgs2 pathway. Front Pharmacol. 2022;13:1057583.
Not in our library10.3389/fphar.2022.1057583
593.
Zhou B, Zhang J, Chen Y, Liu Y, Tang X, Xia P, et al. Puerarin protects against sepsis-induced myocardial injury through AMPK-mediated ferroptosis signaling. Aging (Albany NY). 2022;14(8):3617-3632.
Not in our library10.18632/aging.204033
594.
Zhang J, Wang X, Guan B, Wang X, An X, Wang T, et al. Qing-Xin-Jie-Yu Granule inhibits ferroptosis and stabilizes atherosclerotic plaques by regulating the GPX4/xCT signaling pathway. J Ethnopharmacol. 2023;301:115852.
Not in our library10.1016/j.jep.2022.115852
595.
Yu LM, Dong X, Huang T, Zhao JK, Zhou ZJ, Huang YT, et al. Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1. Apoptosis. 2023;28(3–4):607-626.
Not in our library10.1007/s10495-023-01814-8
596.
Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 · 2020
Corrected
597.
Li RL, Fan CH, Gong SY, Kang S. Effect and mechanism of LRP6 on cardiac myocyte ferroptosis in myocardial infarction. Oxid Med Cell Longev. 2021;2021:8963987.
Not in our library10.1155/2021/8963987
598.
Liu K, Chen S, Lu R. Identification of important genes related to ferroptosis and hypoxia in acute myocardial infarction based on WGCNA. Bioengineered. 2021;12(1):7950-7963.
Not in our library10.1080/21655979.2021.1984004
599.
Libby P. The changing landscape of atherosclerosis. Nature. 2021;592(7855):524-533.
Not in our library10.1038/s41586-021-03392-8
600.
Ferroptosis: the potential value target in atherosclerosis · 2021
No notice
601.
Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, et al. Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction. Eur Heart J. 2020;41(28):2681-2695.
Not in our library10.1093/eurheartj/ehz112
602.
Guo Z, Ran Q, Roberts LJ, Zhou L, Richardson A, Sharan C, et al. Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med. 2008;44(3):343-352.
Not in our library10.1016/j.freeradbiomed.2007.09.009
603.
Poch D, Mandel J. Pulmonary hypertension. Ann Intern Med. 2021;174(4):Itc49-itc64.
Not in our library10.7326/aitc202104200
604.
Kamada H, Kaneyama J, Inoue YY, Noda T, Ueda N, Nakajima K, et al. Long term prognosis in patients with pulmonary hypertension undergoing catheter ablation for supraventricular tachycardia. Sci Rep. 2021;11(1):16176.
Not in our library10.1038/s41598-021-95508-3
605.
Liu SF, Nambiar Veetil N, Li Q, Kucherenko MM, Knosalla C, Kuebler WM. Pulmonary hypertension: linking inflammation and pulmonary arterial stiffening. Front Immunol. 2022;13:959209.
Not in our library10.3389/fimmu.2022.959209
606.
Xu D, Hu YH, Gou X, Li FY, Yang XY, Li YM et al. Oxidative stress and antioxidative therapy in pulmonary arterial hypertension. Molecules. 2022;27(12). doi:10.3390/molecules27123724.
Not in our library10.3390/molecules27123724
607.
Zou HX, Qiu BQ, Lai SQ, Zhou XL, Gong CW, Wang LJ, et al. Iron metabolism and idiopathic pulmonary arterial hypertension: new insights from bioinformatic analysis. Biomed Res Int. 2021;2021:5669412.
Not in our library10.1155/2021/5669412
608.
Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation · 2022
No notice
609.
Murtaza G, Virk HUH, Khalid M, Lavie CJ, Ventura H, Mukherjee D, et al. Diabetic cardiomyopathy - a comprehensive updated review. Prog Cardiovasc Dis. 2019;62(4):315-326.
Not in our library10.1016/j.pcad.2019.03.003
610.
Paolillo S, Marsico F, Prastaro M, Renga F, Esposito L, De Martino F, et al. Diabetic cardiomyopathy: definition, diagnosis, and therapeutic implications. Heart Fail Clin. 2019;15(3):341-347.
Not in our library10.1016/j.hfc.2019.02.003
611.
Pathophysiology of Type 2 Diabetes Mellitus · 2020
No notice
612.
Yang P, Feng J, Peng Q, Liu X, Fan Z. Advanced glycation end products: potential mechanism and therapeutic target in cardiovascular complications under diabetes. Oxid Med Cell Longev. 2019;2019:9570616.
Not in our library10.1155/2019/9570616
613.
Wilson AJ, Gill EK, Abudalo RA, Edgar KS, Watson CJ, Grieve DJ. Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting. Heart. 2018;104(4):293-299.
Not in our library10.1136/heartjnl-2017-311448
614.
Yang S, Wong KH, Hua P, He C, Yu H, Shao D, et al. ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy. Acta Biomater. 2022;140:492-505.
Not in our library10.1016/j.actbio.2021.11.042
615.
Maron BJ, Desai MY, Nishimura RA, Spirito P, Rakowski H, Towbin JA, et al. Management of hypertrophic cardiomyopathy: JACC state-of-the-art review. J Am Coll Cardiol. 2022;79(4):390-414.
Not in our library10.1016/j.jacc.2021.11.021
616.
Wang Z, Xia Q, Su W, Cao M, Sun Y, Zhang M, et al. Exploring the communal pathogenesis, ferroptosis mechanism, and potential therapeutic targets of dilated cardiomyopathy and hypertrophic cardiomyopathy via a microarray data analysis. Front Cardiovasc Med. 2022;9:824756.
Not in our library10.3389/fcvm.2022.824756
617.
Khalili-Tanha G, Moghbeli M. Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells. Cell Mol Biol Lett. 2021;26(1):39.
Not in our library10.1186/s11658-021-00282-9
618.
Mitochondrial-Targeted Therapy for Doxorubicin-Induced Cardiotoxicity · 2022
No notice
619.
Ozcan M, Guo Z, Valenzuela Ripoll C, Diab A, Picataggi A, Rawnsley D, et al. Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity. Cell Metab. 2023.
Not in our library10.1016/j.cmet.2023.02.006
620.
Chen Y, Shi S, Dai Y. Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy. Biomed Pharmacother. 2022;156:113903.
Not in our library10.1016/j.biopha.2022.113903
621.
Therapeutic Targets for DOX-Induced Cardiomyopathy: Role of Apoptosis vs. Ferroptosis · 2022
No notice
622.
Wang Q, Jiang F, Zhao C, Song J, Hu M, Lv Y, et al. miR-21–5p prevents doxorubicin-induced cardiomyopathy by downregulating BTG2. Heliyon. 2023;9(5):e15451.
Not in our library10.1016/j.heliyon.2023.e15451
623.
Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level · 2022
No notice
624.
Fan J, Jiang T, He D. Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases. Front Immunol. 2023;14:1120519.
Not in our library10.3389/fimmu.2023.1120519
625.
Ferroptosis and Autoimmune Diseases · 2022
Not checked
626.
Chen Q, Wang J, Xiang M, Wang Y, Zhang Z, Liang J, et al. The potential role of ferroptosis in systemic lupus erythematosus. Front Immunol. 2022;13:855622.
Not in our library10.3389/fimmu.2022.855622
627.
Zhao T, Yang Q, Xi Y, Xie Z, Shen J, Li Z, et al. Ferroptosis in rheumatoid arthritis: a potential therapeutic strategy. Front Immunol. 2022;13:779585.
Not in our library10.3389/fimmu.2022.779585
628.
Li P, Jiang M, Li K, Li H, Zhou Y, Xiao X, et al. Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity. Nat Immunol. 2021;22(9):1107-1117.
Not in our library10.1038/s41590-021-00993-3
629.
López-Pedrera C, Villalba JM, Patiño-Trives AM, Luque-Tévar M, Barbarroja N, Aguirre M et al. Therapeutic potential and immunomodulatory role of coenzyme Q(10) and its analogues in systemic autoimmune diseases. Antioxidants (Basel). 2021;10(4). 10.3390/antiox10040600.
Not in our library10.3390/antiox10040600
630.
Vats K, Kruglov O, Mizes A, Samovich SN, Amoscato AA, Tyurin VA, et al. Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure. Redox Biol. 2021;47:102143.
Not in our library10.1016/j.redox.2021.102143
631.
Song X, Zhang H, Zhao Y, Lin Y, Tang Q, Zhou X, et al. HMGB1 activates myeloid dendritic cells by up-regulating mTOR pathway in systemic lupus erythematosus. Front Med. 2021;8:636188.
Not in our library10.3389/fmed.2021.636188
632.
Ling H, Li M, Yang C, Sun S, Zhang W, Zhao L, et al. Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis. Rheumatology. 2022;61(11):4521-4534.
Not in our library10.1093/rheumatology/keac069
633.
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models · 2022
No notice
634.
Xie M, Zhu C, Ye Y. Ferroptosis-related molecular clusters and diagnostic model in rheumatoid arthritis. Int J Mol Sci. 2023;24(8). 10.3390/ijms24087342.
Not in our library10.3390/ijms24087342
635.
Xie Z, Hou H, Luo D, An R, Zhao Y, Qiu C. ROS-dependent lipid peroxidation and reliant antioxidant ferroptosis-suppressor-protein 1 in rheumatoid arthritis: a covert clue for potential therapy. Inflammation. 2021;44(1):35-47.
Not in our library10.1007/s10753-020-01338-2
636.
Li RL, Duan HX, Liang Q, Huang YL, Wang LY, Zhang Q, et al. Targeting matrix metalloproteases: a promising strategy for herbal medicines to treat rheumatoid arthritis. Front Immunol. 2022;13:1046810.
Not in our library10.3389/fimmu.2022.1046810
637.
Homma T, Kobayashi S, Fujii J. Methionine deprivation reveals the pivotal roles of cell cycle progression in ferroptosis that is induced by cysteine starvation. Cells. 2022;11(10). 10.3390/cells11101603.
Not in our library10.3390/cells11101603
638.
Hu J, Zhang R, Chang Q, Ji M, Zhang H, Geng R, et al. p53: a regulator of ferroptosis induced by galectin-1 derived peptide 3 in MH7A cells. Front Genet. 2022;13:920273.
Not in our library10.3389/fgene.2022.920273
639.
Zhan Y, Yang Z, Zhan F, Huang Y, Lin S. SIRT1 is transcriptionally repressed by YY1 and suppresses ferroptosis in rheumatoid arthritis. Adv Rheumatol. 2023;63(1):9.
Not in our library10.1186/s42358-023-00289-0
640.
Yang Z, Lin SD, Zhan F, Liu Y, Zhan YW. LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis. Autoimmunity. 2021;54(1):13-22.
Not in our library10.1080/08916934.2020.1846183
641.
SIRT1: A Potential Therapeutic Target in Autoimmune Diseases · 2021
No notice
642.
Wu YJ, Fang WJ, Pan S, Zhang SS, Li DF, Wang ZF, et al. Regulation of Sirt1 on energy metabolism and immune response in rheumatoid arthritis. Int Immunopharmacol. 2021;101(Pt A):108175.
Not in our library10.1016/j.intimp.2021.108175
643.
Chen Y, Wang J, Li J, Zhu J, Wang R, Xi Q, et al. Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway. Eur J Pharmacol. 2021;911:174518.
Not in our library10.1016/j.ejphar.2021.174518
644.
Gu SC, Yuan CX, Gu C. Identification of ferroptosis-related gene signatures associated with multiple sclerosis using weighted gene co-expression network analysis. Medicine. 2022;101(51):e31802.
Not in our library10.1097/md.0000000000031802
645.
Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression · 2021
No notice
646.
Jhee JH, Nam BY, Park JT, Kim HW, Chang TI, Kang EW, et al. CD71 mesangial IgA1 receptor and the progression of IgA nephropathy. Transl Res. 2021;230:34-43.
Not in our library10.1016/j.trsl.2020.10.007
647.
Mohammad G, Matakidou A, Robbins PA, Lakhal-Littleton S. The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload. Kidney Int. 2021;100(3):559-569.
Not in our library10.1016/j.kint.2021.04.034
648.
Fan J, Han Y, Sun H, Sun S, Wang Y, Guo R, et al. Mesenchymal stem cell-derived exosomal microRNA-367–3p alleviates experimental autoimmune encephalomyelitis via inhibition of microglial ferroptosis by targeting EZH2. Biomed Pharmacother. 2023;162:114593.
Not in our library10.1016/j.biopha.2023.114593
649.
HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression · 2021
No notice
650.
Li H, Zeng Y, Luo S, Li Z, Huang F, Liu Z. GPX4 aggravates experimental autoimmune encephalomyelitis by inhibiting the functions of CD4+ T cells. Biochem Biophys Res Commun. 2023;642:57-65.
Not in our library10.1016/j.bbrc.2022.12.034
651.
Luoqian J, Yang W, Ding X, Tuo QZ, Xiang Z, Zheng Z, et al. Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis. Cell Mol Immunol. 2022;19(8):913-924.
Not in our library10.1038/s41423-022-00883-0
652.
Li Q, Chen Z, Yang C, Wang L, Ma J, He T, et al. Role of ferroptosis-associated genes in ankylosing spondylitis and immune cell infiltration. Front Genet. 2022;13:948290.
Not in our library10.3389/fgene.2022.948290
653.
Dong S, Lu Y, Peng G, Li J, Li W, Li M, et al. Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway. Dig Liver Dis. 2021;53(10):1276-1285.
Not in our library10.1016/j.dld.2021.02.011
654.
Jiang H, Fang Y, Wang Y, Li T, Lin H, Lin J, et al. FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3. Int Immunopharmacol. 2023;116:109762.
Not in our library10.1016/j.intimp.2023.109762
655.
Yao X, Sun K, Yu S, Luo J, Guo J, Lin J, et al. Chondrocyte ferroptosis contribute to the progression of osteoarthritis. J Orthop Translat. 2021;27:33-43.
Not in our library10.1016/j.jot.2020.09.006
656.
Ferroptosis in inflammatory arthritis: A promising future · 2022
Not checked
657.
Tang B, Zhu J, Fang S, Wang Y, Vinothkumar R, Li M, et al. Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis. Free Radic Biol Med. 2021;172:312-329.
Not in our library10.1016/j.freeradbiomed.2021.06.012
658.
Hou L, Gong F, Liu B, Yang X, Chen L, Li G, et al. Orally administered titanium carbide nanosheets as anti-inflammatory therapy for colitis. Theranostics. 2022;12(8):3834-3846.
Not in our library10.7150/thno.70668
659.
Li X, Chu Y, Ma R, Dou M, Li S, Song Y, et al. Ferroptosis as a mechanism of oligodendrocyte loss and demyelination in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2022;373:577995.
Not in our library10.1016/j.jneuroim.2022.577995
660.
Zhu L, Chen D, Zhu Y, Pan T, Xia D, Cai T, et al. GPX4-regulated ferroptosis mediates s100-induced experimental autoimmune hepatitis associated with the Nrf2/HO-1 signaling pathway. Oxid Med Cell Longev. 2021;2021:6551069.
Not in our library10.1155/2021/6551069
661.
Luo H, Zhang R. Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the Xc-/GPX4 axis. Exp Ther Med. 2021;21(1):72.
Not in our library10.3892/etm.2020.9504
662.
Zhao C, Chen J, Ye J, Li Z, Su L, Wang J, et al. Structural transformative antioxidants for dual-responsive anti-inflammatory delivery and photoacoustic inflammation imaging. Angew Chem Int Ed Engl. 2021;60(26):14458-14466.
Not in our library10.1002/anie.202100873
663.
Lin D, Zhang M, Luo C, Wei P, Cui K, Chen Z. Targeting ferroptosis attenuates inflammation, fibrosis, and mast cell activation in chronic prostatitis. J Immunol Res. 2022;2022:6833867.
Not in our library10.1155/2022/6833867
664.
Alli AA, Desai D, Elshika A, Conrad M, Proneth B, Clapp W, et al. Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis. Clin Immunol. 2023;248:109213.
Not in our library10.1016/j.clim.2022.109213
665.
Pons-Estel GJ, Alarcón GS, Scofield L, Reinlib L, Cooper GS. Understanding the epidemiology and progression of systemic lupus erythematosus. Semin Arthritis Rheum. 2010;39(4):257-268.
Not in our library10.1016/j.semarthrit.2008.10.007
666.
Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE · 2016
No notice
667.
Li P, Jiang M, Li K, Li H, Zhou Y, Xiao X, et al. Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity. Nat Immunol. 2021;22(9):1107-1117.
Not in our library10.1038/s41590-021-00993-3
668.
Kim SJ, Lee K, Diamond B. Follicular helper T cells in systemic lupus erythematosus. Front Immunol. 2018;9:1793.
Not in our library10.3389/fimmu.2018.01793
669.
Gao X, Song Y, Wu J, Lu S, Min X, Liu L et al. Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus. J Clin Invest. 2022;132(9). 10.1172/jci152345.
Not in our library10.1172/jci152345
670.
Philippou E, Petersson SD, Rodomar C, Nikiphorou E. Rheumatoid arthritis and dietary interventions: systematic review of clinical trials. Nutr Rev. 2021;79(4):410-428.
Not in our library10.1093/nutrit/nuaa033
671.
Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023-2038.
Not in our library10.1016/s0140-6736(16)30173-8
672.
Nygaard G, Firestein GS. Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat Rev Rheumatol. 2020;16(6):316-333.
Not in our library10.1038/s41584-020-0413-5
673.
Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L. Crohn's disease. Lancet. 2017;389(10080):1741-1755.
Not in our library10.1016/s0140-6736(16)31711-1
674.
Ordás I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet. 2012;380(9853):1606-1619.
Not in our library10.1016/s0140-6736(12)60150-0
675.
Zhong W, Xia Z, Hinrichs D, Rosenbaum JT, Wegmann KW, Meyrowitz J, et al. Hemin exerts multiple protective mechanisms and attenuates dextran sulfate sodium-induced colitis. J Pediatr Gastroenterol Nutr. 2010;50(2):132-139.
Not in our library10.1097/mpg.0b013e3181c61591
676.
Pasparakis M. Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases. Nat Rev Immunol. 2009;9(11):778-788.
Not in our library10.1038/nri2655
677.
Chen PH, Wu J, Ding CC, Lin CC, Pan S, Bossa N, et al. Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism. Cell Death Differ. 2020;27(3):1008-1022.
Not in our library10.1038/s41418-019-0393-7
678.
The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection · 2018
No notice
679.
Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis · 2020
No notice
680.
Tan S, Xu J, Lai A, Cui R, Bai R, Li S, et al. Curculigoside exerts significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway. Mol Med Rep. 2019;19(3):2057-2064.
Not in our library10.3892/mmr.2019.9854
681.
Wang S, Liu W, Wang J, Bai X. Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4. Life Sci. 2020;259:118356.
Not in our library10.1016/j.lfs.2020.118356
682.
Chen Y, Zhang P, Chen W, Chen G. Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2/HO-1 signaling pathway. Immunol Lett. 2020;225:9-15.
Not in our library10.1016/j.imlet.2020.06.005
683.
Rodríguez Murúa S, Farez MF, Quintana FJ. The immune response in multiple sclerosis. Annu Rev Pathol. 2022;17:121-139.
Not in our library10.1146/annurev-pathol-052920-040318
684.
Voet S, Prinz M, van Loo G. Microglia in central nervous system inflammation and multiple sclerosis pathology. Trends Mol Med. 2019;25(2):112-123.
Not in our library10.1016/j.molmed.2018.11.005
685.
Gao J, Wang Q, Tang YD, Zhai J, Hu W, Zheng C. When ferroptosis meets pathogenic infections. Trends Microbiol. 2023;31(5):468-479.
Not in our library10.1016/j.tim.2022.11.006
686.
Lopez-Jimenez AT, Mostowy S. Emerging technologies and infection models in cellular microbiology. Nat Commun. 2021;12(1):6764.
Not in our library10.1038/s41467-021-26641-w
687.
Chen X, Kang R, Kroemer G, Tang D. Ferroptosis in infection, inflammation, and immunity. J Exp Med. 2021;218(6). 10.1084/jem.20210518.
Not in our library10.1084/jem.20210518
688.
Wang MP, Joshua B, Jin NY, Du SW, Li C. Ferroptosis in viral infection: the unexplored possibility. Acta Pharmacol Sin. 2022;43(8):1905-1915.
Not in our library10.1038/s41401-021-00814-1
689.
Newton HJ, Ang DK, van Driel IR, Hartland EL. Molecular pathogenesis of infections caused by Legionella pneumophila. Clin Microbiol Rev. 2010;23(2):274-298.
Not in our library10.1128/cmr.00052-09
690.
The molecular machinery of regulated cell death · 2019
No notice
691.
Yamane D, Hayashi Y, Matsumoto M, Nakanishi H, Imagawa H, Kohara M, et al. FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication. Cell Chem Biol. 2022;29(5):799-810.e4.
Not in our library10.1016/j.chembiol.2021.07.022
692.
Qiang L, Zhang Y, Lei Z, Lu Z, Tan S, Ge P, et al. A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination. Nat Commun. 2023;14(1):1430.
Not in our library10.1038/s41467-023-37148-x
693.
Amaral EP, Costa DL, Namasivayam S, Riteau N, Kamenyeva O, Mittereder L, et al. A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis. J Exp Med. 2019;216(3):556-570.
Not in our library10.1084/jem.20181776
694.
Sestrin2 protects dendrite cells against ferroptosis induced by sepsis · 2021
No notice
695.
Wang Y, Chen D, Xie H, Jia M, Sun X, Peng F, et al. AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3. Cell Mol Life Sci. 2022;79(5):228.
Not in our library10.1007/s00018-022-04248-8
696.
Shen K, Wang X, Wang Y, Jia Y, Zhang Y, Wang K, et al. miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury. Redox Biol. 2023;62:102655.
Not in our library10.1016/j.redox.2023.102655
697.
Wang YM, Gong FC, Qi X, Zheng YJ, Zheng XT, Chen Y, et al. Mucin 1 inhibits ferroptosis and sensitizes vitamin e to alleviate sepsis-induced acute lung injury through GSK3β/Keap1-Nrf2-GPX4 pathway. Oxid Med Cell Longev. 2022;2022:2405943.
Not in our library10.1155/2022/2405943
698.
Shimizu J, Murao A, Nofi C, Wang P, Aziz M. Extracellular CIRP promotes GPX4-mediated ferroptosis in sepsis. Front Immunol. 2022;13:903859.
Not in our library10.3389/fimmu.2022.903859
699.
Neutrophil extracellular traps mediate m 6 A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells · 2022
No notice
700.
Amaral EP, Foreman TW, Namasivayam S, Hilligan KL, Kauffman KD, Barbosa Bomfim CC et al. GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection. J Exp Med. 2022;219(11). 10.1084/jem.20220504.
Not in our library10.1084/jem.20220504
701.
Ma C, Wu X, Zhang X, Liu X, Deng G. Corrigendum: Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of intracellular iron and reactive oxygen species of macrophages in response to Bacillus Calmette-Guerin infection. Front Cell Infect Microbiol. 2022;12:1105336.
Not in our library10.3389/fcimb.2022.1105336
702.
Shi X, Li C, Cheng L, Ullah H, Sha S, Kang J, et al. Mycobacterium tuberculosis Rv1324 protein contributes to mycobacterial persistence and causes pathological lung injury in mice by inducing ferroptosis. Microbiol Spectr. 2023;11(1):e0252622.
Not in our library10.1128/spectrum.02526-22
703.
Liu Y, Chen W, Cen Y, Zhao X, Chen Z, Liang Y, et al. Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis. Chem Biol Interact. 2023;376:110439.
Not in our library10.1016/j.cbi.2023.110439
704.
Dar HH, Epperly MW, Tyurin VA, Amoscato AA, Anthonymuthu TS, Souryavong AB et al. P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis. JCI Insight. 2022;7(4). 10.1172/jci.insight.156013.
Not in our library10.1172/jci.insight.156013
705.
Dar HH, Anthonymuthu TS, Ponomareva LA, Souryavong AB, Shurin GV, Kapralov AO, et al. A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO(•) sabotage of theft-ferroptosis. Redox Biol. 2021;45:102045.
Not in our library10.1016/j.redox.2021.102045
706.
Vaillancourt M, Galdino ACM, Limsuwannarot SP, Celedonio D, Dimitrova E, Broerman M, et al. A compensatory RNase E variation increases Iron Piracy and Virulence in multidrug-resistant Pseudomonas aeruginosa during Macrophage infection. PLoS Pathog. 2023;19(4):e1010942.
Not in our library10.1371/journal.ppat.1010942
707.
Wang Y, Wang L, Sun T, Shen S, Li Z, Ma X, et al. Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs. Int J Oral Sci. 2023;15(1):8.
Not in our library10.1038/s41368-022-00213-0
708.
Komissarov AA, Karaseva MA, Roschina MP, Shubin AV, Lunina NA, Kostrov SV et al. Individual expression of hepatitis a virus 3C protease induces ferroptosis in human cells In vitro. Int J Mol Sci. 2021;22(15). 10.3390/ijms22157906.
Not in our library10.3390/ijms22157906
709.
Zhang Q, Qu Y, Zhang Q, Li F, Li B, Li Z, et al. Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis. Cell Biol Toxicol. 2022.
Not in our library10.1007/s10565-021-09684-z
710.
Liu L, Lv Z, Wang M, Zhang D, Liu D, Zhu F. HBV enhances sorafenib resistance in hepatocellular carcinoma by reducing ferroptosis via SRSF2-mediated abnormal PCLAF splicing. Int J Mol Sci. 2023;24(4). 10.3390/ijms24043263.
Not in our library10.3390/ijms24043263
711.
Miao X, Yin Y, Chen Y, Bi W, Yin Y, Chen S et al. Bidirectionally regulating viral and cellular ferroptosis with metastable iron sulfide against influenza virus. Adv Sci (Weinh). 2023:e2206869. 10.1002/advs.202206869.
Not in our library10.1002/advs.202206869
712.
Liu C, Wu X, Bing X, Qi W, Zhu F, Guo N, et al. H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells. Free Radic Biol Med. 2023;204:226-242.
Not in our library10.1016/j.freeradbiomed.2023.05.004
713.
Kung YA, Chiang HJ, Li ML, Gong YN, Chiu HP, Hung CT, et al. Acyl-coenzyme a synthetase long-chain family member 4 Is involved in viral replication organelle formation and facilitates virus replication via ferroptosis. mBio. 2022;13(1):e0271721.
Not in our library10.1128/mbio.02717-21
714.
Dysregulation of Cytosolic c-di-GMP in Edwardsiella piscicida Promotes Cellular Non-Canonical Ferroptosis · 2022
Not checked
715.
Xu XQ, Xu T, Ji W, Wang C, Ren Y, Xiong X, et al. Herpes simplex virus 1-induced ferroptosis contributes to viral encephalitis. mBio. 2023;14(1):e0237022.
Not in our library10.1128/mbio.02370-22
716.
Cao L, Qin R, Liu J. Farnesoid X receptor protects against lipopolysaccharide-induced endometritis by inhibiting ferroptosis and inflammatory response. Int Immunopharmacol. 2023;118:110080.
Not in our library10.1016/j.intimp.2023.110080
717.
Burton EM, Voyer J, Gewurz BE. Epstein-Barr virus latency programs dynamically sensitize B cells to ferroptosis. Proc Natl Acad Sci U S A. 2022;119(11):e2118300119.
Not in our library10.1073/pnas.2118300119
718.
TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1 · 2022
No notice
719.
Wang Y, Tian Q, Hao Y, Yao W, Lu J, Chen C, et al. The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4(+) T cells by preventing ferroptosis. Nat Immunol. 2022;23(2):303-317.
Not in our library10.1038/s41590-021-01090-1
720.
Xiao Q, Yan L, Han J, Yang S, Tang Y, Li Q, et al. Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4(+) T lymphocytes in HIV-infected immune non-responders. EBioMedicine. 2022;86:104382.
Not in our library10.1016/j.ebiom.2022.104382
721.
Kannan M, Sil S, Oladapo A, Thangaraj A, Periyasamy P, Buch S. HIV-1 Tat-mediated microglial ferroptosis involves the miR-204-ACSL4 signaling axis. Redox Biol. 2023;62:102689.
Not in our library10.1016/j.redox.2023.102689
722.
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages · 2022
No notice
723.
Uridine Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Ferroptosis of Macrophage · 2023
No notice
724.
Lv YW, Du Y, Ma SS, Shi YC, Xu HC, Deng L, et al. Proanthocyanidins attenuates ferroptosis against influenza-induced acute lung injury in mice by reducing IFN-γ. Life Sci. 2023;314:121279.
Not in our library10.1016/j.lfs.2022.121279
725.
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury · 2022
No notice
726.
Kang R, Zeng L, Zhu S, Xie Y, Liu J, Wen Q, et al. Lipid peroxidation drives gasdermin d-mediated pyroptosis in lethal polymicrobial sepsis. Cell Host Microbe. 2018;24(1):97-108.e4.
Not in our library10.1016/j.chom.2018.05.009
727.
Geng S, Hao P, Wang D, Zhong P, Tian F, Zhang R, et al. Zinc oxide nanoparticles have biphasic roles on Mycobacterium-induced inflammation by activating autophagy and ferroptosis mechanisms in infected macrophages. Microb Pathog. 2023;180:106132.
Not in our library10.1016/j.micpath.2023.106132
728.
Huang M, Wang Z, Yao L, Zhang L, Gou X, Mo H, et al. Ferric chloride induces ferroptosis in Pseudomonas aeruginosa and heals wound infection in a mouse model. Int J Antimicrob Agents. 2023;61(5):106794.
Not in our library10.1016/j.ijantimicag.2023.106794
729.
Ousingsawat J, Schreiber R, Gulbins E, Kamler M, Kunzelmann KP. aeruginosa induced lipid peroxidation causes ferroptotic Cell death in airways. Cell Physiol Biochem. 2021;55(5):590-604.
Not in our library10.33594/000000437
730.
Nishiga M, Jahng JWS, Wu JC. Ferroptosis of pacemaker cells in COVID-19. Circ Res. 2022;130(7):978-980.
Not in our library10.1161/circresaha.122.320951
731.
Carota G, Ronsisvalle S, Panarello F, Tibullo D, Nicolosi A, Li Volti G. Role of iron chelation and protease inhibition of natural products on COVID-19 infection. J Clin Med. 2021;10(11). 10.3390/jcm10112306.
Not in our library10.3390/jcm10112306
732.
Chavarría AP, Vázquez RRV, Cherit JGD, Bello HH, Suastegui HC, Moreno-Castañeda L, et al. Antioxidants and pentoxifylline as coadjuvant measures to standard therapy to improve prognosis of patients with pneumonia by COVID-19. Comput Struct Biotechnol J. 2021;19:1379-1390.
Not in our library10.1016/j.csbj.2021.02.009
733.
Li S, Xu W, Wang H, Tang T, Ma J, Cui Z, et al. Ferroptosis plays an essential role in the antimalarial mechanism of low-dose dihydroartemisinin. Biomed Pharmacother. 2022;148:112742.
Not in our library10.1016/j.biopha.2022.112742
734.
Parkins MD, Somayaji R, Waters VJ. Epidemiology, Biology, and Impact of Clonal Pseudomonas aeruginosa Infections in Cystic Fibrosis. Clin Microbiol Rev. 2018;31(4). 10.1128/cmr.00019-18.
Not in our library10.1128/cmr.00019-18
735.
de Sousa T, Hébraud M, Dapkevicius M, Maltez L, Pereira JE, Capita R et al. Genomic and metabolic characteristics of the pathogenicity in pseudomonas aeruginosa. Int J Mol Sci. 2021;22(23). 10.3390/ijms222312892.
Not in our library10.3390/ijms222312892
736.
Langton Hewer SC, Smith S, Rowbotham NJ, Yule A, Smyth AR. Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis. Cochrane Database Syst Rev. 2023;6(6):Cd004197.
Not in our library10.1002/14651858.cd004197.pub6
737.
Albin OR, Kaye KS, McCreary EK, Pogue JM. Less is more? antibiotic treatment duration in pseudomonas aeruginosa ventilator-associated pneumonia. Clin Infect Dis. 2023;76(4):745-749.
Not in our library10.1093/cid/ciac784
738.
Jean SS, Liu IM, Hsieh PC, Kuo DH, Liu YL, Hsueh PR. Off-label use versus formal recommendations of conventional and novel antibiotics for the treatment of infections caused by multidrug-resistant bacteria. Int J Antimicrob Agents. 2023;61(5):106763.
Not in our library10.1016/j.ijantimicag.2023.106763
739.
Kanj SS, Bassetti M, Kiratisin P, Rodrigues C, Villegas MV, Yu Y, et al. Clinical data from studies involving novel antibiotics to treat multidrug-resistant Gram-negative bacterial infections. Int J Antimicrob Agents. 2022;60(3):106633.
Not in our library10.1016/j.ijantimicag.2022.106633
740.
Jeong GJ, Khan F, Khan S, Tabassum N, Mehta S, Kim YM. Pseudomonas aeruginosa virulence attenuation by inhibiting siderophore functions. Appl Microbiol Biotechnol. 2023;107(4):1019-1038.
Not in our library10.1007/s00253-022-12347-6
741.
Rada B, Leto TL. Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections. Trends Microbiol. 2013;21(2):73-81.
Not in our library10.1016/j.tim.2012.10.004
742.
Bourzac K. Infectious disease: beating the big three. Nature. 2014;507(7490):S4-7.
Not in our library10.1038/507s4a
743.
Ma C, Wu X, Zhang X, Liu X, Deng G. Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of intracellular iron and reactive oxygen species of macrophages in response to Bacillus Calmette-Guerin infection. Front Cell Infect Microbiol. 2022;12:1004148.
Not in our library10.3389/fcimb.2022.1004148
744.
Ferroptosis in sepsis: The mechanism, the role and the therapeutic potential · 2022
No notice
745.
Haak BW, Wiersinga WJ. The role of the gut microbiota in sepsis. Lancet Gastroenterol Hepatol. 2017;2(2):135-143.
Not in our library10.1016/s2468-1253(16)30119-4
746.
van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017;17(7):407-420.
Not in our library10.1038/nri.2017.36
747.
Matsushita M, Freigang S, Schneider C, Conrad M, Bornkamm GW, Kopf M. T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J Exp Med. 2015;212(4):555-568.
Not in our library10.1084/jem.20140857
748.
Xie Z, Xu M, Xie J, Liu T, Xu X, Gao W, et al. Inhibition of ferroptosis attenuates glutamate excitotoxicity and nuclear autophagy in a CLP septic mouse model. Shock. 2022;57(5):694-702.
Not in our library10.1097/shk.0000000000001893
749.
Gao N, Tang AL, Liu XY, Chen J, Zhang GQ. p53-Dependent ferroptosis pathways in sepsis. Int Immunopharmacol. 2023;118:110083.
Not in our library10.1016/j.intimp.2023.110083
750.
Terrault NA, Levy MT, Cheung KW, Jourdain G. Viral hepatitis and pregnancy. Nat Rev Gastroenterol Hepatol. 2021;18(2):117-130.
Not in our library10.1038/s41575-020-00361-w
751.
Castaneda D, Gonzalez AJ, Alomari M, Tandon K, Zervos XB. From hepatitis A to E: a critical review of viral hepatitis. World J Gastroenterol. 2021;27(16):1691-1715.
Not in our library10.3748/wjg.v27.i16.1691
752.
Odenwald MA, Paul S. Viral hepatitis: past, present, and future. World J Gastroenterol. 2022;28(14):1405-1429.
Not in our library10.3748/wjg.v28.i14.1405
753.
Cell Death in Liver Diseases: A Review · 2020
No notice
754.
Liu C, Zhao K, Chen Y, Yao Y, Tang J, Wang J, et al. Mitochondrial glycerol-3-phosphate dehydrogenase restricts HBV replication via the TRIM28-mediated degradation of HBx. J Virol. 2023;97(5):e0058023.
Not in our library10.1128/jvi.00580-23
755.
Han Y, Zhu J, Yang L, Nilsson-Payant BE, Hurtado R, Lacko LA, et al. SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells. Circ Res. 2022;130(7):963-977.
Not in our library10.1161/circresaha.121.320518
756.
Nuszkiewicz J, Sutkowy P, Wróblewski M, Pawłowska M, Wesołowski R, Wróblewska J et al. Links between vitamin K, ferroptosis and SARS-CoV-2 infection. Antioxidants. 2023;12(3). 10.3390/antiox12030733.
Not in our library10.3390/antiox12030733
757.
Peterlin BM, Trono D. Hide, shield and strike back: how HIV-infected cells avoid immune eradication. Nat Rev Immunol. 2003;3(2):97-107.
Not in our library10.1038/nri998
758.
Redd AD, Quinn TC, Tobian AA. Frequency and implications of HIV superinfection. Lancet Infect Dis. 2013;13(7):622-628.
Not in our library10.1016/s1473-3099(13)70066-5
759.
Subashini D, Dinesha TR, Srirama RB, Boobalan J, Poongulali S, Chitra DA, et al. Mitochondrial DNA content of peripheral blood mononuclear cells in ART untreated & stavudine/zidovudine treated HIV-1-infected patients. Indian J Med Res. 2018;148(2):207-214.
Not in our library10.4103/ijmr.ijmr_1144_16
760.
Perrin S, Cremer J, Roll P, Faucher O, Ménard A, Reynes J, et al. HIV-1 infection and first line ART induced differential responses in mitochondria from blood lymphocytes and monocytes: the ANRS EP45 "Aging" study. PLoS One. 2012;7(7):e41129.
Not in our library10.1371/journal.pone.0041129
761.
Sena-Dos-Santos C, Braga-da-Silva C, Marques D, Azevedo Dos Santos Pinheiro J, Ribeiro-Dos-Santos Â, Cavalcante GC. Unraveling cell death pathways during malaria infection: What do we know so far? Cells. 2021;10(2). 10.3390/cells10020479.
Not in our library10.3390/cells10020479
762.
Malaria's WHO moment. Nat Biotechnol. 2021;39(11):1322. 10.1038/s41587-021-01129-6.
Not in our library10.1038/s41587-021-01129-6
763.
Chen S, Fan F, Zhang Y, Zeng J, Li Y, Xu N, et al. Metabolites from scutellarin alleviating deferoxamine-induced hypoxia injury in BV2 cells cultured on microfluidic chip combined with a mass spectrometer. Talanta. 2023;259:124478.
Not in our library10.1016/j.talanta.2023.124478
764.
Gattermann N, Muckenthaler MU, Kulozik AE, Metzgeroth G, Hastka J. The evaluation of iron deficiency and iron overload. Dtsch Arztebl Int. 2021;118(49):847-856.
Not in our library10.3238/arztebl.m2021.0290
765.
Loughnan R, Ahern J, Tompkins C, Palmer CE, Iversen J, Thompson WK, et al. Association of genetic variant linked to hemochromatosis with brain magnetic resonance imaging measures of iron and movement disorders. JAMA Neurol. 2022;79(9):919-928.
Not in our library10.1001/jamaneurol.2022.2030
766.
Crichton R. Iron metabolism: from molecular mechanisms to clinical consequences. other: other. 2018.
Not in our library
767.
Griffiths WJH, Besser M, Bowden DJ, Kelly DA. Juvenile haemochromatosis. Lancet Child Adolesc Health. 2021;5(7):524-530.
Not in our library10.1016/s2352-4642(20)30392-8
768.
Iron Overload, Oxidative Stress, and Ferroptosis in the Failing Heart and Liver · 2021
No notice
769.
Iron and the Pathophysiology of Diabetes · 2023
No notice
770.
Hsu CC, Senussi NH, Fertrin KY, Kowdley KV. Iron overload disorders. Hepatol Commun. 2022;6(8):1842-1854.
Not in our library10.1002/hep4.2012
771.
Baas FS, Rishi G, Swinkels DW, Subramaniam VN. Genetic diagnosis in hereditary hemochromatosis: discovering and understanding the biological relevance of variants. Clin Chem. 2021;67(10):1324-1341.
Not in our library10.1093/clinchem/hvab130
772.
Baschant U, Altamura S, Steele-Perkins P, Muckenthaler MU, Spasi MV, Hofbauer LC, et al. Iron effects versus metabolic alterations in hereditary hemochromatosis driven bone loss. Trends Endocrinol Metab. 2022;33(9):652-663.
Not in our library10.1016/j.tem.2022.06.004
773.
Cartella I, Tavecchia GA, Quattrocchi G, Giannattasio C, Volpato E, Palazzini M, et al. A heart of iron: juvenile haemochromatosis presents with cardiac failure. Lancet. 2022;400(10352):616.
Not in our library10.1016/s0140-6736(22)01285-5
774.
Palmer WC, Vishnu P, Sanchez W, Aqel B, Riegert-Johnson D, Seaman LAK, et al. Diagnosis and management of genetic iron overload disorders. J Gen Intern Med. 2018;33(12):2230-2236.
Not in our library10.1007/s11606-018-4669-2
775.
Srole DN, Ganz T. Erythroferrone structure, function, and physiology: iron homeostasis and beyond. J Cell Physio. 2021;236(7):4888-4901.
Not in our library10.1002/jcp.30247
776.
Ferroptosis in liver disease: new insights into disease mechanisms · 2021
No notice
777.
Kim E, Jean J, Kearns C, Ballard DH. Perivenous hepatic iron deposition in alcoholic cirrhosis. Radiographics. 2021;41(6):1570-1571.
Not in our library10.1148/rg.2021210190
778.
Li Y, Qin M, Zhong W, Liu C, Deng G, Yang M, et al. RAGE promotes dysregulation of iron and lipid metabolism in alcoholic liver disease. Redox Biol. 2023;59:102559.
Not in our library10.1016/j.redox.2022.102559
779.
Harrison-Findik DD, Schafer D, Klein E, Timchenko NA, Kulaksiz H, Clemens D, et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006;281(32):22974-22982.
Not in our library10.1074/jbc.m602098200
780.
Arezes J, Foy N, McHugh K, Sawant A, Quinkert D, Terraube V, et al. Erythroferrone inhibits the induction of hepcidin by BMP6. Blood. 2018;132(14):1473-1477.
Not in our library10.1182/blood-2018-06-857995
781.
Rosato BE, Marra R, D'Onofrio V, Del Giudice F, Della Monica S, Iolascon A et al. SEC23B loss-of-function suppresses hepcidin expression by impairing glycosylation pathway in human hepatic cells. Int J Mol Sci. 2022;23(3). 10.3390/ijms23031304.
Not in our library10.3390/ijms23031304
782.
Marketa D-C, Kamila B, Karolina K, Jitka C, Vaclav H, Jan H, et al. Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease. J Cell Mol Med. 2014;18(9):1840-1850.
Not in our library10.1111/jcmm.12310
783.
Jiang L, Wang J, Wang K, Wang H, Wu Q, Yang C, et al. RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation. Blood. 2021;138(8):689-705.
Not in our library10.1182/blood.2020008986
784.
Xue M, Tian Y, Sui Y, Zhao H, Gao H, Liang H, et al. Protective effect of fucoidan against iron overload and ferroptosis-induced liver injury in rats exposed to alcohol. Biomed Pharmacother. 2022;153:113402.
Not in our library10.1016/j.biopha.2022.113402
785.
Yuan R, Tao X, Liang S, Pan Y, He L, Sun J, et al. Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative stress. Biomed Pharmacother. 2018;99:537-542.
Not in our library10.1016/j.biopha.2018.01.079
786.
CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload · 2021
No notice
787.
Corradini E, Buzzetti E, Dongiovanni P, Scarlini S, Caleffi A, Pelusi S, et al. Ceruloplasmin gene variants are associated with hyperferritinemia and increased liver iron in patients with NAFLD. J Hepatol. 2021;75(3):506-513.
Not in our library10.1016/j.jhep.2021.03.014
788.
Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, et al. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022;34(8):1201-13.e5.
Not in our library10.1016/j.cmet.2022.07.006
789.
Feng H, Liu Q, Deng Z, Li H, Zhang H, Song J, et al. Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis. Stem Cell Res Ther. 2022;13(1):450.
Not in our library10.1186/s13287-022-03147-w
790.
Duygu Dee H-F, Elizabeth K, Callie C, John E, Nikolai T, John G. Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology. 2007;46(6):1979-1985.
Not in our library10.1002/hep.21895
791.
Yu L, He M, Liu S, Dou X, Li L, Gu N, et al. Fluorescent egg white-based carbon dots as a high-sensitivity iron chelator for the therapy of nonalcoholic fatty liver disease by iron overload in zebrafish. ACS Appl Mater Interfaces. 2021;13(46):54677-54689.
Not in our library10.1021/acsami.1c14674
792.
Zhang L, Dai X, Wang L, Cai J, Shen J, Shen Y, et al. Iron overload accelerated lipid metabolism disorder and liver injury in rats with non-alcoholic fatty liver disease. Front Nutr. 2022;9:961892.
Not in our library10.3389/fnut.2022.961892
793.
Bathish B, Robertson H, Dillon JF, Dinkova-Kostova AT, Hayes JD. Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2. Free Radic Biol Med. 2022;188:221-261.
Not in our library10.1016/j.freeradbiomed.2022.06.226
794.
Qi X, Song A, Ma M, Wang P, Zhang X, Lu C, et al. Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease. Cell Prolif. 2021;54(9):e13107.
Not in our library10.1111/cpr.13107
795.
Hu Z, Li Y, Ma B, Lei S, Wang X. Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLD. Front Nutr. 2022;9:952056.
Not in our library10.3389/fnut.2022.952056
796.
Targeting Mitochondrial ROS-Mediated Ferroptosis by Quercetin Alleviates High-Fat Diet-Induced Hepatic Lipotoxicity · 2022
Not checked
797.
Tong J, Lan XT, Zhang Z, Liu Y, Sun DY, Wang XJ, et al. Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis. Acta Pharmacol Sin. 2023;44(5):1014-1028.
Not in our library10.1038/s41401-022-01010-5
798.
Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine · 2013
Corrected
799.
Domínguez JF, Ng AC, Poudel G, Stout JC, Churchyard A, Chua P, et al. Iron accumulation in the basal ganglia in Huntington's disease: cross-sectional data from the IMAGE-HD study. J Neurol Neurosurg Psychiatry. 2016;87(5):545-549.
Not in our library10.1136/jnnp-2014-310183
800.
Ayton S, Portbury S, Kalinowski P, Agarwal P, Diouf I, Schneider JA, et al. Regional brain iron associated with deterioration in Alzheimer's disease: a large cohort study and theoretical significance. Alzheimers Dement. 2021;17(7):1244-1256.
Not in our library10.1002/alz.12282
801.
Peng Y, Chang X, Lang M. Iron homeostasis disorder and Alzheimer's Disease. Int J Mol Sci. 2021;22(22). 10.3390/ijms222212442.
Not in our library10.3390/ijms222212442
802.
Aberrant Cerebral Iron Trafficking Co-morbid With Chronic Inflammation: Molecular Mechanisms and Pharmacologic Intervention · 2022
Not checked
803.
Spagnoli C, Fusco C, Pisani F. Pediatric-onset epilepsy and developmental epileptic encephalopathies followed by early-onset parkinsonism. Int J Mol Sci. 2023;24(4). 10.3390/ijms24043796.
Not in our library10.3390/ijms24043796
804.
Petit F, Drecourt A, Dussiot M, Zangarelli C, Hermine O, Munnich A, et al. Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts. Blood. 2021;137(15):2090-2102.
Not in our library10.1182/blood.2020006987
805.
Payne RM. Cardiovascular research in friedreich ataxia: unmet needs and opportunities. JACC Basic Transl Sci. 2022;7(12):1267-1283.
Not in our library10.1016/j.jacbts.2022.04.005
806.
Pellerin D, Danzi MC, Wilke C, Renaud M, Fazal S, Dicaire MJ, et al. Deep intronic FGF14 GAA repeat expansion in late-onset cerebellar ataxia. N Engl J Med. 2023;388(2):128-141.
Not in our library10.1056/nejmoa2207406
807.
Rodrigues AV, Batelu S, Hinton TV, Rotondo J, Thompson L, Brunzelle JS, et al. Drosophila melanogaster frataxin: protein crystal and predicted solution structure with identification of the iron-binding regions. Acta crystallographica Section D, Structural Biology. 2023;79(Pt 1):22-30.
Not in our library10.1107/s2059798322011639
808.
Rodríguez-Pascau L, Britti E, Calap-Quintana P, Dong YN, Vergara C, Delaspre F, et al. PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia. Neurobiol Dis. 2021;148:105162.
Not in our library10.1016/j.nbd.2020.105162
809.
The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia · 2021
Not checked
810.
Xu L, Sun Z, Xing Z, Liu Y, Zhao H, Tang Z, et al. Cur@SF NPs alleviate Friedreich's ataxia in a mouse model through synergistic iron chelation and antioxidation. J Nanobiotechnology. 2022;20(1):118.
Not in our library10.1186/s12951-022-01333-9
811.
Villa C, Legato M, Umbach A, Riganti C, Jones R, Martini B et al. Treatment with ROS detoxifying gold quantum clusters alleviates the functional decline in a mouse model of Friedreich ataxia. Sci Transl Med. 2021;13(607). 10.1126/scitranslmed.abe1633.
Not in our library10.1126/scitranslmed.abe1633
812.
Zhang X, Li LX, Ding H, Torres VE, Yu C, Li X. Ferroptosis promotes cyst growth in autosomal dominant polycystic kidney disease mouse models. J Am Soc Nephrol. 2021;32(11):2759-2776.
Not in our library10.1681/asn.2021040460
813.
Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities · 2023
No notice
814.
Karmi O, Sohn YS, Marjault HB, Israeli T, Leibowitz G, Ioannidis K et al. A combined drug treatment that reduces mitochondrial iron and reactive oxygen levels recovers insulin secretion in NAF-1-deficient pancreatic cells. Antioxidants. 2021;10(8). 10.3390/antiox10081160.
Not in our library10.3390/antiox10081160
815.
Zhao X, Ma Y, Shi M, Huang M, Xin J, Ci S, et al. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1. Cell Mol Life Sci. 2023;80(6):159.
Not in our library10.1007/s00018-023-04802-y
816.
Petry SF, A Rm, Rawat D, Brunner L, Lerch N, Zhou M et al. Loss and recovery of glutaredoxin 5 is inducible by diet in a murine model of diabesity and mediated by free fatty acids in vitro. Antioxidants. 2022;11(4). 10.3390/antiox11040788.
Not in our library10.3390/antiox11040788
817.
Tasnim H, Ding H. Electron transfer activity of the nanodisc-bound mitochondrial outer membrane protein mitoNEET. Free Radic Biol Med. 2022;187:50-58.
Not in our library10.1016/j.freeradbiomed.2022.05.011
818.
You Y, Liu C, Liu T, Tian M, Wu N, Yu Z, et al. FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease. Free Radic Biol Med. 2022;193(Pt 2):808-819.
Not in our library10.1016/j.freeradbiomed.2022.10.322
819.
Xiong H, Zhang C, Han L, Xu T, Saeed K, Han J, et al. Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity. Hepatology. 2022;76(2):387-403.
Not in our library10.1002/hep.32270
820.
Chakraborty S, Andrieux G, Kastl P, Adlung L, Altamura S, Boehm ME, et al. Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo. Cell Rep. 2022;40(12):111360.
Not in our library10.1016/j.celrep.2022.111360
821.
Jadhav S, Protchenko O, Li F, Baratz E, Shakoury-Elizeh M, Maschek A, et al. Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1. Free Radical Biol Med. 2021;175:18-27.
Not in our library10.1016/j.freeradbiomed.2021.08.232
822.
Federti E, Vinchi F, Iatcenko I, Ghigo A, Matte A, Toya SCM, et al. Duality of Nrf2 in iron-overload cardiomyopathy. Haematologica. 2023;108(5):1335-1348.
Not in our library10.3324/haematol.2022.281995
823.
Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V et al. Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. J Clin Invest. 2021;131(11). 10.1172/JCI136459.
Not in our library10.1172/jci136459
824.
Medina-Carbonero M, Sanz-Alcázar A, Britti E, Delaspre F, Cabiscol E, Ros J, et al. Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations. Cell Mol Life Sci. 2022;79(2):74.
Not in our library10.1007/s00018-021-04100-5
825.
Cotticelli MG, Xia S, Truitt R, Doliba NM, Rozo AV, Tobias JW et al. Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response. Dis Model Mech. 2023;16(5). 10.1242/dmm.049497.
Not in our library10.1242/dmm.049497
826.
Culley MK, Rao RJ, Mehta M, Zhao J, El Khoury W, Harvey LD, et al. Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function. Vascul Pharmacol. 2023;151:107181.
Not in our library10.1016/j.vph.2023.107181
827.
Guo T, Yu Y, Yan W, Zhang M, Yi X, Liu N, et al. Erythropoietin ameliorates cognitive dysfunction in mice with type 2 diabetes mellitus via inhibiting iron overload and ferroptosis. Exp Neurol. 2023;365:114414.
Not in our library10.1016/j.expneurol.2023.114414
828.
Lv Z, Han J, Li J, Guo H, Fei Y, Sun Z, et al. Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis. EBioMedicine. 2022;84:104258.
Not in our library10.1016/j.ebiom.2022.104258
829.
Miao Y, Chen Y, Xue F, Liu K, Zhu B, Gao J, et al. Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression. EBioMedicine. 2022;76:103847.
Not in our library10.1016/j.ebiom.2022.103847
830.
Noonan ML, Ni P, Solis E, Marambio YG, Agoro R, Chu X, et al. Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23. Bone Res. 2023;11(1):7.
Not in our library10.1038/s41413-022-00241-w
831.
Sun K, Hou L, Guo Z, Wang G, Guo J, Xu J, et al. JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy. Free Radic Biol Med. 2023;200:87-101.
Not in our library10.1016/j.freeradbiomed.2023.03.008
832.
Di Modica SM, Tanzi E, Olivari V, Lidonnici MR, Pettinato M, Pagani A, et al. Transferrin receptor 2 (Tfr2) genetic deletion makes transfusion-independent a murine model of transfusion-dependent β-thalassemia. Am J Hematol. 2022;97(10):1324-1336.
Not in our library10.1002/ajh.26673
833.
Ledesma-Colunga MG, Baschant U, Weidner H, Alves TC, Mirtschink P, Hofbauer LC, et al. Transferrin receptor 2 deficiency promotes macrophage polarization and inflammatory arthritis. Redox Biol. 2023;60:102616.
Not in our library10.1016/j.redox.2023.102616
834.
Xiao X, Moschetta GA, Xu Y, Fisher AL, Alfaro-Magallanes VM, Dev S, et al. Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia. Blood. 2023;141(4):422-432.
Not in our library10.1182/blood.2022017811
835.
Wang Y, Bi R, Quan F, Cao Q, Lin Y, Yue C, et al. Ferroptosis involves in renal tubular cell death in diabetic nephropathy. Eur J Pharmacol. 2020;888:173574.
Not in our library10.1016/j.ejphar.2020.173574
836.
Chiang S, Kalinowski DS, Dharmasivam M, Braidy N, Richardson DR, Huang MLH. The potential of the novel NAD(+) supplementing agent, SNH6, as a therapeutic strategy for the treatment of Friedreich's ataxia. Pharmacol Res. 2020;155:104680.
Not in our library10.1016/j.phrs.2020.104680
837.
Abdul Y, Li W, Ward R, Abdelsaid M, Hafez S, Dong G, et al. Deferoxamine treatment prevents post-stroke vasoregression and neurovascular unit remodeling leading to improved functional outcomes in yype 2 male diabetic rats: role of endothelial ferroptosis. Transl Stroke Res. 2021;12(4):615-630.
Not in our library10.1007/s12975-020-00844-7
838.
Pan Z, He Q, Zeng J, Li S, Li M, Chen B, et al. Naringenin protects against iron overload-induced osteoarthritis by suppressing oxidative stress. Phytomedicine. 2022;105:154330.
Not in our library10.1016/j.phymed.2022.154330
839.
Mattè A, Kosinski PA, Federti E, Dang L, Recchiuti A, Russo R et al. Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice. Haematologica. 2023. 10.3324/haematol.2022.282614.
Not in our library10.3324/haematol.2022.282614
840.
Sripetchwandee J, Khamseekaew J, Svasti S, Srichairatanakool S, Fucharoen S, Chattipakorn N et al. Corrigendum to "Deferiprone and efonidipine mitigated iron-overload induced neurotoxicity in wild-type and thalassemic mice" [Life Sci. 239 (2019) 116878]. Life Sci. 2023;315:121401. 10.1016/j.lfs.2023.121401.
Not in our library10.1016/j.lfs.2023.121401
841.
Adramerina A, Printza N, Hatzipantelis E, Symeonidis S, Tarazi L, Teli A et al. Use of deferasirox film-coated tablets in pediatric patients with transfusion dependent thalassemia: a single center experience. Biology. 2022;11(2). 10.3390/biology11020247.
Not in our library10.3390/biology11020247
842.
Sriwichaiin S, Thiennimitr P, Thonusin C, Sarichai P, Buddhasiri S, Kumfu S, et al. Deferiprone has less benefits on gut microbiota and metabolites in high iron-diet induced iron overload thalassemic mice than in iron overload wild-type mice: a preclinical study. Life Sci. 2022;307:120871.
Not in our library10.1016/j.lfs.2022.120871
843.
Abbina S, Abbasi U, Gill A, Leitch H, Kizhakkedathu JN. Active transport nanochelators for the reduction of liver iron burden in iron overload. J Control Release. 2022;350:857-869.
Not in our library10.1016/j.jconrel.2022.08.056
844.
Burton LH, Afzali MF, Radakovich LB, Campbell MA, Culver LA, Olver CS, et al. Systemic administration of a pharmacologic iron chelator reduces cartilage lesion development in the Dunkin-Hartley model of primary osteoarthritis. Free Radic Biol Med. 2022;179:47-58.
Not in our library10.1016/j.freeradbiomed.2021.12.257
845.
Feng W, Xiao Y, Zhao C, Zhang Z, Liu W, Ma J, et al. New deferric amine compounds efficiently chelate excess iron to treat iron overload disorders and to prevent ferroptosis. Adv Sci. 2022;9(29):e2202679.
Not in our library10.1002/advs.202202679
846.
Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551-4556.
Not in our library10.1021/ja411006a
847.
Ferroptosis Induction in Pentylenetetrazole Kindling and Pilocarpine-Induced Epileptic Seizures in Mice · 2019
No notice
848.
Chen KN, Guan QW, Yin XX, Wang ZJ, Zhou HH, Mao XY. Ferrostatin-1 obviates seizures and associated cognitive deficits in ferric chloride-induced posttraumatic epilepsy via suppressing ferroptosis. Free Radic Biol Med. 2022;179:109-118.
Not in our library10.1016/j.freeradbiomed.2021.12.268
849.
van Vuren A, Kerkhoffs JL, Schols S, Rijneveld A, Nur E, Peereboom D, et al. Proton pump inhibition for secondary hemochromatosis in hereditary anemia: a phase III placebo-controlled randomized cross-over clinical trial. Am J Hematol. 2022;97(7):924-932.
Not in our library10.1002/ajh.26581
850.
Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin · 2021
No notice
851.
Sindone AP, De Pasquale C, Amerena J, Burdeniuk C, Chan A, Coats A, et al. Consensus statement on the current pharmacological prevention and management of heart failure. Med J Aust. 2022;217(4):212-217.
Not in our library10.5694/mja2.51656
852.
Fuchs Andersen C, Omar M, Glenth?j A, El Fassi D, HJ Ml, Lindholm Kurtzhals JA et al. Effects of empagliflozin on erythropoiesis in heart failure: data from the Empire HF trial. Eur J Heart Fail. 2023;25(2):226–34. 10.1002/ejhf.2735.
Not in our library10.1002/ejhf.2735
853.
Chifotides HT, Bose P, Verstovsek S. Momelotinib: an emerging treatment for myelofibrosis patients with anemia. J Hematol Oncol. 2022;15(1):7.
Not in our library10.1186/s13045-021-01157-4
854.
Radadiya PS, Thornton MM, Puri RV, Yerrathota S, Dinh-Phan J, Magenheimer B et al. Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease. JCI insight. 2021;6(8). 10.1172/jci.insight.141299.
Not in our library10.1172/jci.insight.141299
855.
He Q, Yang J, Pan Z, Zhang G, Chen B, Li S, et al. Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis. Biomed Pharmacother. 2023;157:113915.
Not in our library10.1016/j.biopha.2022.113915
856.
Du K, Zhou Q, Wang Z, Mo C, Dong W, Wei N et al. Polydatin ameliorates inflammation and oxidative stress associated with MSU-induced gouty arthritis in mice by regulating PPAR-γ and ferritin activation. Life Sci. 2023:121766. 10.1016/j.lfs.2023.121766.
Not in our library10.1016/j.lfs.2023.121766
857.
Stockwell BR. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Cell. 2022;185(14):2401-2421.
Not in our library10.1016/j.cell.2022.06.003
858.
Wu H, Li D, Zhang T, Zhao G. Novel mechanisms of perioperative neurocognitive disorders: ferroptosis and pyroptosis. Neurochem Res. 2023. 10.1007/s11064-023-03963-3.
Not in our library10.1007/s11064-023-03963-3
859.
Li P, Yu J, Huang F, Zhu YY, Chen DD, Zhang ZX, et al. SLC7A11-associated ferroptosis in acute injury diseases: mechanisms and strategies. Eur Rev Med Pharmacol Sci. 2023;27(10):4386-4398.
Not in our library10.26355/eurrev_202305_32444
860.
Xie Y, Kang R, Klionsky DJ, Tang D. GPX4 in cell death, autophagy, and disease. Autophagy. 2023:1–18. 10.1080/15548627.2023.2218764.
Not in our library10.1080/15548627.2023.2218764
861.
Yang M, Luo H, Yi X, Wei X, Jiang DS. The epigenetic regulatory mechanisms of ferroptosis and its implications for biological processes and diseases. MedComm. 2023;4(3):e267.
Not in our library10.1002/mco2.267

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In defence of ferroptosis · 2025
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