Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China

Abstract

BACKGROUND: The ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept all over the world, posing a great pressure on critical care resources due to large number of patients needing critical care. Statements from front-line experts in the field of intensive care are urgently needed. METHODS: Sixteen front-line experts in China fighting against the COVID-19 epidemic in Wuhan were organized to develop an expert statement after 5 rounds of expert seminars and discussions to provide trustworthy recommendation on the management of critically ill COVID-19 patients. Each expert was assigned tasks within their field of expertise to provide draft statements and rationale. Parts of the expert statement are based on epidemiological and clinical evidence, without available scientific evidences. RESULTS: A comprehensive document with 46 statements are presented, including protection of medical personnel, etiological treatment, diagnosis and treatment of tissue and organ functional impairment, psychological interventions, immunity therapy, nutritional support, and transportation of critically ill COVID-19 patients. Among them, 5 recommendations were strong (Grade 1), 21 were weak (Grade 2), and 20 were experts' opinions. A strong agreement from voting participants was obtained for all recommendations. CONCLUSION: There are still no targeted therapies for COVID-19 patients. Dynamic monitoring and supportive treatment for the restoration of tissue vascularization and organ function are particularly important.

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References 151

1. 1.

   World Health Organization. Global Surveillance for human infection with coronavirus disease (COVID-19). 2020. https://www.who.int/publications-detail/global-surveillance-for-human-infection-with-novel-coronavirus-(2019-ncov).

   Not in our library

2. 2.

   World Health Organization. Coronavirus disease (COVID-2019) situation reports. 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.

   Not in our library

3. 3.

   World Health Organization, Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. 2020. https://who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected.

   Not in our library

4. 4.

   The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19)-China. China CDC Weekly. 2020;2:113-122.

   Not in our library

5. 5.

   Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020.

   Not in our library10.1016/s2213-2600(20)30079-5

6. 6.

   National Health Commission & State Administration of Traditional Chinese Medicine. Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial version 7.0). 2020, Mar 3. http://www.nhc.gov.cn/xcs/zhengcwj/202003/46c9294a7dfe4cef80dc7f5912eb1989/files/ce3e6945832a438eaae415350a8ce964.pdf.

   Not in our library

7. 7.

   Wax RS, Christian MD. Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients. Can J Anaesth. 2020.

   Not in our library10.1007/s12630-020-01591-x

8. 8.

   World Health Organization, Five moments for hand hygiene. https://www.who.int/gpsc/tools/Fivemoments/en/.

   Not in our library

9. 9.

   World Health Organization, Infection prevention and control during health care when COVID-19 is suspected. 2020 March 19, https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125.

   Not in our library

10. 10.

    World Health Organization, Coronavirus disease (COVID-19) outbreak: rights, roles and responsibilities of health workers, including key considerations for occupational safety and health. 2020 March 19, https://www.who.int/publications-detail/coronavirus-disease-(covid-19)-outbreak-rights-roles-and-responsibilities-of-health-workers-including-keyconsiderations-for-occupational-safety-and-health.

    Not in our library

11. 11.

    Zhe Jiang University, Handbook of COVID-19 Prevention and Treatment. 2020, http://che.zju.edu.cn/cheen/2020/0401/c27758a2021088/page.htm

    Not in our library

12. 12.

    Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, et al. Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med. 2019.

    Not in our library10.1007/s00134-020-06022-5

13. 13.

    World Health Organization, Rational use of personal protective equipment (PPE) for coronavirus disease (COVID-19). 2020 March 19 https://apps.who.int/iris/bitstream/handle/10665/331498/WHO-2019-nCoV-IPCPPE_use-2020.2-eng.pdf.

    Not in our library

14. 14.

    Twu SJ, Chen TJ, Chen CJ, Olsen SJ, Lee LT, Fisk T, et al. Control measures for severe acute respiratory syndrome (SARS) in Taiwan. Emerg Infect Dis. 2003;9:718-720.

    Not in our library10.3201/eid0906.030283

15. 15.

    Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2019.

    Not in our library10.1001/jama.2020.1585

16. 16.
    Aerosol Generating Procedures and Risk of Transmission of Acute Respiratory Infections to Healthcare Workers: A Systematic Review · 2012

    No notice
17. 17.

    General Office of National Health Committee. Guideline of Prevention and Control of Novel Coronavirus Infection Within Medical Facilities (first edition). 2020. http://www.nhc.gov.cn/yzygj/s7659/202001/b91fdab7c304431eb082d67847d27e14.shtml.

    Not in our library

18. 18.

    Zuo MZ, Huang YG, Ma WH, Xue ZG, Zhang JQ, Gong YH, et al. Chinese Society of Anesthesiology Task Force on Airway Management: expert recommendations for tracheal intubation in critically ill patients with novel coronavirus disease 2019. Chin Med Sci J. 2020.

    Not in our library10.24920/003724

19. 19.

    Lewis SR, Butler AR, Parker J, Cook TM, Schofield-Robinson OJ, Smith AF. Videolaryngoscopy versus direct laryngoscopy for adult patients requiring tracheal intubation: a Cochrane Systematic Review. Br J Anaesth. 2017;119:369-383.

    Not in our library10.1093/bja/aex228

20. 20.

    Centers for Disease Control and Prevention, Interim Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed Coronavirus Disease 2019 (COVID-19) in Healthcare Settings, 2020. https://www.cdc.gov/coronavirus/2019-ncov/hcp/infection-control.html.

    Not in our library

21. 21.

    Xu Y, Meng M, Li L, Liu J, Chen DC. Recommendations for bronchoscopy procedures in severe COVID-19 patients. Chin J Crit Care Intensive Care Med. 2020;6:E031.

    Not in our library

22. 22.

    Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Sevestre J, et al. Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: a pilot observational study. Travel Med Infect Dis. 2020;1:101663.

    Not in our library10.1016/j.tmaid.2020.101663

23. 23.
    Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection · 2020

    No notice
24. 24.

    Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020.

    Not in our library10.1056/nejmoa2001282

25. 25.

    Zhu Z, Lu Z, Xu T, Chen C, Yang G, Zha T, et al. Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19. J Infect. 2020.

    Not in our library10.1016/j.jinf.2020.03.060

26. 26.

    Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, et al. Compassionate use of remdesivir for patients with severe COVID-19. N Engl J Med. 2020.

    Not in our library10.1056/nehmoa2007016

27. 27.

    Wang YM, Zhang DY, Du GH, Du RH, Zhao JP, Jin Y, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. 2020.

    Not in our library10.1016/s0140-6736(20)31022-9

28. 28.

    Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, et al. Compassionate Use of remdesivir for patients with severe Covid-19. N Engl J Med. 2020.

    Not in our library10.1056/nejmoa2007016

29. 29.

    Gilead. Gilead Announces Approval of Veklury® (remdesivir) in Japan for Patients With Severe COVID-19, 2020. https://www.gilead.com/news-and-press/press-room/press-releases/2020/5/gilead-announces-approval-of-veklury-remdesivir-in-japan-for-patients-with-severe-covid19.

    Not in our library

30. 30.

    Casadevall A, Pirofski LA. The convalescent sera option for containing COVID-19. J Clin Invest. 2020.

    Not in our library10.1172/jci138003

31. 31.

    Luke TC, Kilbane EM, Jackson JL, Hoffman SL. Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? Ann Intern Med. 2006;145:599-609.

    Not in our library10.7326/0003-4819-145-8-200610170-00139

32. 32.

    Cheng Y, Wong R, Soo YOY, Wong WS, Lee CK, Ng MHL, et al. Use of convalescent plasma therapy in SARS patients in Hong Kong. Eur J Clin Microbiol Infect Dis. 2005;24:44-46.

    Not in our library10.1007/s10096-004-1271-9

33. 33.

    Hung IF, To KK, Lee CK, Lee KL, Chan K, Yan WW, et al. Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection. Clin Infect Dis. 2011;52:447-456.

    Not in our library10.1093/cid/ciq106

34. 34.

    Ko JH, Seok H, Cho SY, Ha YE, Baek JY, Kim SH, et al. Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience. Antivir Ther. 2018;23(7):617-622.

    Not in our library10.3851/imp3243

35. 35.

    Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et al. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA. 2020.

    Not in our library10.1001/jama.2020.4783

36. 36.
    Effectiveness of convalescent plasma therapy in severe COVID-19 patients · 2020

    No notice
37. 37.

    Marano G, Vaglio S, Pupella S, Facco G, Catalano L, Liumbruno GM, et al. Convalescent plasma: new evidence for an old therapeutic tool? Blood Transfus. 2016;14:152-157.

    Not in our library10.2450/2015.0131-15

38. 38.

    Delclaux C, L’Her E, Alberti C, Mancebo J, Abroug F, Conti G, et al. Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask: a randomized controlled trial. JAMA. 2000;284:2352-2560.

    Not in our library10.1001/jama.284.18.2352

39. 39.

    Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015;372:2185-2196.

    Not in our library10.1056/nejmoa1503326

40. 40.

    Bellani G, Laffey JG, Pham T, Madotto F, Fan E, Brochard L, et al. Non-invasive Ventilation of Patients with ARDS: insights from the LUNG SAFE Study. Am J Respir Crit Care Med. 2017;195(1):67-77.

    Not in our library10.1164/rccm.201606-1306oc

41. 41.

    Agarwal R, Aggarwal AN, Gupta D. Role of noninvasive ventilation in acute lung injury/acute respiratory distress syndrome: a proportion meta-analysis. Respir Care. 2010;55:1653-1660.

    Not in our library

42. 42.

    Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, et al. Timing of intubation and clinical outcomes in adults with acute respiratory distress syndrome. Crit Care Med. 2016;44:120-129.

    Not in our library10.1097/ccm.0000000000001359

43. 43.

    Carteaux G, Millán-Guilarte T, De Prost N, Razazi K, Abid S, Thille AW, et al. Failure of noninvasive ventilation for de novo acute hypoxemic respiratory failure: role of tidal volume. Crit Care Med. 2016;44:282-290.

    Not in our library10.1097/ccm.0000000000001379

44. 44.

    Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, et al. An index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med. 2019;199:1368-1376.

    Not in our library10.1164/rccm.201803-0589oc

45. 45.

    Villar J, Kacmarek RM, Perez-Mendez L, Aguirre-Jaime A. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit Care Med. 2006;34:1311-1318.

    Not in our library10.1097/01.ccm.0000215598.84885.01

46. 46.

    Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301-1308.

    Not in our library10.1056/nejm200005043421801

47. 47.

    Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015;372:747-755.

    Not in our library10.1056/nejmsa1410639

48. 48.

    Hodgson C, Goligher EC, Young ME, Keating JL, Holland AE, Romero L, et al. Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation. Cochrane Database Syst Rev. 2016;11:CD006667.

    Not in our library10.1002/14651858.cd006667.pub3

49. 49.

    Pan C, Chen L, Lu C, Zhang W, Xia JA, Sklar MC, et al. Lung recruitability in SARS-CoV-2 associated acute respiratory distress syndrome: a single-center, observational study. Am J Respir Crit Care Med. 2020.

    Not in our library10.1164/rccm.202003-0527le

50. 50.

    Chen L, Del Sorbo L, Grieco DL, Junhasavasdikul D, Rittayamai N, Soliman I, et al. Potential for lung recruitment estimated by the recruitment-to-inflation ratio in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2019;201:178-187.

    Not in our library10.1164/rccm.201902-0334oc

51. 51.

    Gattinoni L, Pelosi P, Crotti S, Valenza F. Effects of positive end-expiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome. Am J Respir Crit Care Med. 1995;151:1807-1814.

    Not in our library10.1164/ajrccm.151.6.7767524

52. 52.

    Kacmarek RM, Villar J, Sulemanji D, Montiel R, Ferrando C, Blanco J, et al. Open lung approach for the acute respiratory distress syndrome: a pilot. Randomized controlled trial. Crit Care Med. 2016;44:32-42.

    Not in our library10.1097/ccm.0000000000001383

53. 53.

    Sud S, Friedrich JO, Taccone P, Polli F, Adhikari NK, Latini R, et al. Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med. 2010;36:585-599.

    Not in our library10.1007/s00134-009-1748-1

54. 54.

    Blanch LL. Clinical studies of tracheal gas insufflation. Respir Care. 2001;46:158-166.

    Not in our library

55. 55.

    Santini A, Protti A, Langer T, Comini B, Monti M, Sparacino CC, et al. Prone position ameliorates lung elastance and increases functional residual capacity independently from lung recruitment. Intensive Care Med Exp. 2015;3:55.

    Not in our library10.1186/s40635-015-0055-0

56. 56.

    Guerin C, Mancebo J. Prone positioning and neuromuscular blocking agents are part of standard care in severe ARDS patients: yes. Intensive Care Med. 2015;41:2195-2197.

    Not in our library10.1007/s00134-015-3918-7

57. 57.

    Zochios V, Parhar K, Vieillard-Baron A. Protecting the right ventricle in ARDS: the role of prone ventilation. J Cardiothorac Vasc Anesth. 2018;32:2248-2251.

    Not in our library10.1053/j.jvca.2018.01.007

58. 58.

    Guérin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2016;368:2159-2168.

    Not in our library10.1056/nejmoa1214103

59. 59.

    World Health Organization. Coronavirus disease (COVID-2019) situation reports. 2020, March 23. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200323-sitrep-63-covid-19.pdf?sfvrsn=b617302d_4.

    Not in our library

60. 60.

    Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2019.

    Not in our library10.1056/nejmoa2002032

61. 61.

    Wu ZY, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China Summary of a report of 72314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2019.

    Not in our library10.1001/jama.2020.2648

62. 62.
    Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study · 2020

    No notice
63. 63.

    Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China. Lancet. 2020;395:497-506.

    Not in our library10.1016/s0140-6736(20)30183-5

64. 64.

    Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507-513.

    Not in our library10.1016/s0140-6736(20)30211-7

65. 65.

    ELSO Guidance Document: Use of ECMO in COVID-19 Patients During the Pandemic.

    Not in our library

66. 66.

    Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, et al. An official American Thoracic Society/European Society Of Intensive Care Medicine/society of critical care medicine clinical practice guideline: mechanical ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2017;195:1253-1263.

    Not in our library10.1164/rccm.201703-0548st

67. 67.

    Meng L, Qiu H, Wan L, Ai Y, Xue Z, Guo Q, et al. Intubation and Ventilation amid the COVID-19 Outbreak. Anesthesiology. 2020.

    Not in our library10.1097/aln.0000000000003296

68. 68.

    Alhogbani T. Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus. Ann Saudi Med. 2016;36:78-80.

    Not in our library10.5144/0256-4947.2016.78

69. 69.

    Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020.

    Not in our library10.1001/jamacardio.2020.0950

70. 70.

    Li SS, Cheng CW, Fu CL, Chan YH, Lee MP, Chan JW, et al. Left ventricular performance in patients with severe acute respiratory syndrome: a 30-day echocardiographic follow-up study. Circulation. 2003;108:1798-1803.

    Not in our library10.1161/01.cir.0000094737.21775.32

71. 71.

    Oudit GY, Kassiri Z, Jiang C, Liu PP, Poutanen SM, Penninger JM, et al. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Eur J Clin Invest. 2009;39:618-625.

    Not in our library10.1111/j.1365-2362.2009.02153.x

72. 72.

    Mancia G, Rea F, Ludergnani M, Apolone G, Corrao G. Renin-Angiotensin-Aldosterone System Blockers and the Risk of Covid-19. N Engl J Med. 2020.

    Not in our library10.1056/nejmoa2006923

73. 73.

    Fujikura Y, Kawano S, Kouzaki Y, Shinoda M, Hara Y, Shinkai M, et al. Mortality and severity evaluation by routine pneumonia prediction models among Japanese patients with 2009 pandemic influenza A (H1N1) pneumonia. Respir Investig. 2014;52:280-287.

    Not in our library10.1016/j.resinv.2014.04.003

74. 74.

    Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020.

    Not in our library10.1007/s00134-020-05991-x

75. 75.

    Bednarczyk JM, Fridfinnson JA, Kumar A, Blanchard L, Rabbani R, Bell D, et al. Incorporating dynamic assessment of fluid responsiveness into goal-directed therapy: a systematic review and meta-analysis. Crit Care Med. 2017;45:1538-1545.

    Not in our library10.1097/ccm.0000000000002554

76. 76.

    Monnet X, Marik P, Teboul JL. Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis. Intensive Care Med. 2016;42:1935-1947.

    Not in our library10.1007/s00134-015-4134-1

77. 77.
    Does pulse pressure variation predict fluid responsiveness in critically ill patients? A systematic review and meta-analysis · 2014

    No notice
78. 78.

    Preau S, Bortolotti P, Colling D, Dewavrin F, Colas V, Voisin B, et al. Diagnostic accuracy of the inferior vena cava collapsibility to predict fluid responsiveness in spontaneously breathing patients with sepsis and acute circulatory failure. Crit Care Med. 2017;45:e290-e297.

    Not in our library10.1097/ccm.0000000000002090

79. 79.

    Pan J, Peng M, Liao C, Hu X, Wang A, Li X. Relative efficacy and safety of early lactate clearance-guided therapy resuscitation in patients with sepsis: a meta-analysis. Medicine (Baltimore). 2019;98:e14453.

    Not in our library10.1097/md.0000000000014453

80. 80.

    Jozwiak M, Silva S, Persichini R, Anguel N, Osman D, Richard C, et al. Extravascular lung water is an independent prognostic factor in patients with acute respiratory distress syndrome. Crit Care Med. 2013;41:472-480.

    Not in our library10.1097/ccm.0b013e31826ab377

81. 81.

    Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006;34:344-353.

    Not in our library10.1097/01.ccm.0000194725.48928.3a

82. 82.

    Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020.

    Not in our library10.1016/s2213-2600(20)30076-x

83. 83.

    Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354:2564-2575.

    Not in our library10.1056/nejmoa062200

84. 84.

    Lewis SR, Pritchard MW, Evans DJ, Butler AR, Alderson P, Smith AF, et al. Colloids versus crystalloids for fluid resuscitation in critically ill people. Cochrane Database Syst Rev. 2018;8:CD000567.

    Not in our library10.1002/14651858.cd000567.pub7

85. 85.
    Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease · 2020

    Not checked
86. 86.

    Zhou Y, Zhang Z, Tian J, Xiong S. Risk factors associated with disease progression in a cohort of patients infected with the 2019 novel coronavirus. Ann Palliat Med. 2019.

    Not in our library10.21037/apm.2020.03.26

87. 87.

    Okumura J, Shindo Y, Takahashi K, Sano M, Sugino Y, Yagi T, et al. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: impact of β-lactam plus macrolide combination therapy. Respirology. 2018;23:526-534.

    Not in our library10.1111/resp.13232

88. 88.

    Wu KK, Chan SK, Ma TM. Posttraumatic stress, anxiety, and depression in survivors of severe acute respiratory syndrome (SARS). J Trauma Stress. 2005;18:39-42.

    Not in our library10.1002/jts.20004

89. 89.

    Lee AM, Wong JG, McAlonan GM, Cheung V, Cheung C, Sham PC, et al. Stress and psychological distress among SARS survivors 1 year after the outbreak. Can J Psychiatry. 2007;52:233-240.

    Not in our library10.1177/070674370705200405

90. 90.

    Carthy T, Benaroya-Milshtein N, Valevski A, Apter A. Emotional reactivity and regulation following citalopram therapy in children and adolescents with anxiety disorders. J Child Adolesc Psychopharmacol. 2017;27:43-51.

    Not in our library10.1089/cap.2015.0067

91. 91.

    Flint AJ, Meyers BS, Rothschild AJ, Whyte EM, Alexopoulos GS, Rudorfer MV, et al. Effect of continuing olanzapine vs placebo on relapse among patients with psychotic depression in remission: the STOP-PD II randomized clinical trial. JAMA. 2019;322:622-631.

    Not in our library10.1001/jama.2019.10517

92. 92.

    Pisani MA, Friese RS, Gehlbach BK, Schwab RJ, Weinhouse GL, Jones SF. Sleep in the intensive care unit. Am J Respir Crit Care Med. 2015;191:731-738.

    Not in our library10.1164/rccm.201411-2099ci

93. 93.

    Boyko Y, Jennum P, Nikolic M, Holst R, Oerding H, Toft P. Sleep in intensive care unit: the role of environment. J Crit Care. 2017;37:99-105.

    Not in our library10.1016/j.jcrc.2016.09.005

94. 94.

    Akansel N, Kaymakci S. Effects of intensive care unit noise on patients: a study on coronary artery bypass graft surgery patients. J Clin Nurs. 2008;17:1581-1590.

    Not in our library10.1111/j.1365-2702.2007.02144.x

95. 95.

    Voigt LP, Reynolds K, Mehryar M, Chan WS, Kostelecky N, Pastores SM, et al. Monitoring sound and light continuously in an intensive care unit patient room: a pilot study. J Crit Care. 2017;39:36-39.

    Not in our library10.1016/j.jcrc.2016.12.020

96. 96.

    Litton E, Carnegie V, Elliott R, Webb SA. The efficacy of earplugs as a sleep hygiene strategy for reducing delirium in the ICU: a systematic review and meta-analysis. Crit Care Med. 2016;44:992-999.

    Not in our library10.1097/ccm.0000000000001557

97. 97.

    Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, et al. Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium: a randomized clinical trial. JAMA. 2016;315:1460-1468.

    Not in our library10.1001/jama.2016.2707

98. 98.

    Al-Aama T, Brymer C, Gutmanis I, Woolmore-Goodwin SM, Esbaugh J, Dasgupta M. Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. Int J Geriatr Psychiatry. 2011;26:687-694.

    Not in our library10.1002/gps.2582

99. 99.

    Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, et al. Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial. JAMA Psychiatry. 2014;71:397-403.

    Not in our library10.1001/jamapsychiatry.2013.3320

100. 100.

     Fontaine GV, Der Nigoghossian C, Hamilton LA. Melatonin, ramelteon, suvorexant, and dexmedetomidine to promote sleep and prevent delirium in critically ill patients: a narrative review with practical applications. Crit Care Nurs Q. 2020;43:232-250.

     Not in our library10.1097/cnq.0000000000000304

101. 101.

     Balas MC, Weinhouse GL, Denehy L, Chanques G, Rochwerg B, Misak CJ, et al. Interpreting and implementing the 2018 pain, agitation/sedation, delirium, immobility, and sleep disruption clinical practice guideline. Crit Care Med. 2018;46:1464-1470.

     Not in our library10.1097/ccm.0000000000003307

102. 102.

     Conti G, Arcangeli A, Antonelli M, Cavaliere F, Costa R, Simeoni F, et al. Sedation with sufentanil in patients receiving pressure support ventilation has no effects on respiration: a pilot study. Can J Anaesth. 2004;51:494-499.

     Not in our library10.1007/bf03018315

103. 103.

     Zhu Y, Wang Y, Du B, Xi X. Could remifentanil reduce duration of mechanical ventilation in comparison with other opioids for mechanically ventilated patients? A systematic review and meta-analysis. Crit Care. 2017;21:206.

     Not in our library10.1186/s13054-017-1789-8

104. 104.

     Cooke M, Chaboyer W, Schluter P, Foster M, Harris D, Teakle R. The effect of music on discomfort experienced by intensive care unit patients during turning: a randomized cross-over study. Int J Nurs Pract. 2010;16:125-131.

     Not in our library10.1111/j.1440-172x.2010.01819.x

105. 105.

     Gorji HM, Nesami BM, Ayyasi M, Ghafari R, Yazdani J. Comparison of ice packs application and relaxation therapy in pain reduction during chest tube removal following cardiac surgery. N Am J Med Sci. 2014;6:19-24.

     Not in our library10.4103/1947-2714.125857

106. 106.

     Balzer F, Weiß B, Kumpf O, Treskatsch S, Spies C, Wernecke KD, et al. Early deep sedation is associated with decreased in-hospital and two-year follow-up survival. Crit Care. 2015;19:197.

     Not in our library10.1186/s13054-015-0929-2

107. 107.

     Shehabi Y, Bellomo R, Reade MC, Bailey M, Bass F, Howe B, et al. Early goal-directed sedation versus standard sedation in mechanically ventilated critically ill patients: a pilot study. Crit Care Med. 2013;41:1983-1991.

     Not in our library10.1097/ccm.0b013e31828a437d

108. 108.

     Shehabi Y, Botha JA, Boyle MS, Ernest D, Freebairn RC, Jenkins IR, et al. Sedation and delirium in the intensive care unit: an Australian and New Zealand perspective. Anaesth Intensive Care. 2008;36:570-578.

     Not in our library10.1177/0310057x0803600423

109. 109.

     Shehabi Y, Chan L, Kadiman S, Alias A, Ismail WN, Tan MA, et al. Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med. 2013;39:910-918.

     Not in our library10.1007/s00134-013-2830-2

110. 110.

     Tanaka LM, Azevedo LC, Park M, Schettino G, Nassar AP, Réa-Neto A, et al. Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study. Crit Care. 2018;18:R156.

     Not in our library10.1186/cc13995

111. 111.

     Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet. 2008;371:126-134.

     Not in our library10.1016/s0140-6736(08)60105-1

112. 112.

     Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41:263-306.

     Not in our library10.1097/ccm.0b013e3182783b72

113. 113.

     Bucknall TK, Manias E, Presneill JJ. A randomized trial of protocol-directed sedation management for mechanical ventilation in an Australian intensive care unit. Crit Care Med. 2008;36:1444-1450.

     Not in our library10.1097/ccm.0b013e318168f82d

114. 114.

     Zeng Q, Li YZ, Huang G, Wu W, Dong SY, Xu Y. Mortality of COVID-19 is associated with cellular immune function compared to immune function in Chinese Han population. MedRxiv. 2020.

     Not in our library10.1101/2020.03.08.20031229

115. 115.

     Leap J, Hill J, Patel K, Shah A. Paralytics, sedation, and steroids in acute respiratory distress syndrome. Crit Care Nurs Q. 2019;42:376-391.

     Not in our library10.1097/cnq.0000000000000278

116. 116.

     Chen RC, Tang XP, Tan SY, Liang BL, Wan ZY, Fang JQ, et al. Treatment of Severe Acute Respiratory Syndrome With Glucosteroids: the Guangzhou Experience. Chest. 2006;129:1441-1452.

     Not in our library10.1378/chest.129.6.1441

117. 117.
     Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial · 2016

     No notice
118. 118.

     Steinberg KP, Hudson LD, Goodman RB, Hough CL, Lanken PN, Hyzy R, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med. 2006;354:1671-1684.

     Not in our library10.1056/nejmoa051693

119. 119.

     Moreno G, Rodríguez A, Reyes LF, Gomez J, Sole-Violan J, Díaz E, et al. Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study. Intensive Care Med. 2018;44:1470-1482.

     Not in our library10.1007/s00134-018-5332-4

120. 120.

     Kim SH, Hong SB, Yun SC, Choi WI, Ahn JJ, Lee YJ, Lee HB, Lim CM, Koh Y. Corticosteroid treatment in critically ill patients with pandemic influenza A/H1N1 2009 infection: analytic strategy using propensity scores. Am J Respir Crit Care Med. 2011;183:1207-1214.

     Not in our library10.1164/rccm.201101-0110oc

121. 121.

     Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2019.

     Not in our library10.1001/jamainternmed.2020.0994

122. 122.

     King R, Tuthill C. Immune modulation with thymosin alpha 1 treatment. Vitam Horm. 2016;102:151-178.

     Not in our library10.1016/bs.vh.2016.04.003

123. 123.

     Wu J, Zhou L, Liu J, Ma G, Kou Q, He Z, et al. The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial. Crit Care. 2013;17:R8.

     Not in our library10.1186/cc11932

124. 124.
     Effective treatment of severe COVID-19 patients with tocilizumab · 2020

     No notice
125. 125.

     U.S. Phase 2/3 adaptive-designed trial in hospitalized COVID-19 patients. https://seekingalpha.com/pr/17848770-sanofi-and-regeneron-provide-update-on-u-s-phase-2-3-adaptive-designed-trial-in-hospitalized.

     Not in our library

126. 126.

     Schauwvlieghe AFAD, Rijnders BJA, Philips N, Verwijs R, Vanderbeke L, Van Tienen C, et al. Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study. Lancet Respir Med. 2018;6:782-792.

     Not in our library10.1016/s2213-2600(18)30274-1

127. 127.

     Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63:e61-e111.

     Not in our library10.1093/cid/ciw353

128. 128.

     Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O’Grady NP, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;49:1-45.

     Not in our library10.1086/599376

129. 129.

     Yang X, Yang Q, Wang Y, Wu Y, Xu J, Yu Y, et al. Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost. 2020.

     Not in our library10.1111/jth.14848

130. 130.

     Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020.

     Not in our library10.1016/s0140-6736(20)30566-3

131. 131.

     Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020.

     Not in our library10.1111/jth.14768

132. 132.

     Wada H, Thachil J, Di Nisio M, Mathew P, Kurosawa S, Gando S, et al. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. J Thromb Haemost. 2013.

     Not in our library10.1111/jth.12155

133. 133.

     Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020.

     Not in our library10.1111/jth.14830

134. 134.

     Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM, Kaptein FHJ, van Paassen J, Stals MAM, Huisman MV, Endeman H. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020.

     Not in our library10.1016/j.thromres.2020.04.013

135. 135.

     Li X, Ma X. The role of heparin in sepsis: much more than just an anticoagulant. Br J Haematol. 2017;179:389-398.

     Not in our library10.1111/bjh.14885

136. 136.

     Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2019.

     Not in our library10.1111/jth.14817

137. 137.

     Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney impairment is associated with in-hospital death of COVID-19 patients. MedRxiv. 2020.

     Not in our library10.1101/2020.02.18.20023242

138. 138.

     Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of 2019 novel coronavirus infection in China. MedRxiv. 2019.

     Not in our library10.1101/2020.02.06.20020974

139. 139.

     Yang L, Xing G, Wang L, Wu Y, Li S, Xu G, et al. Acute kidney injury in China: a cross-sectional survey. Lancet. 2015;386:1465-1471.

     Not in our library10.1016/s0140-6736(15)00344-x

140. 140.

     Xu X, Nie S, Liu Z, Chen C, Xu G, Zha Y, et al. Epidemiology and Clinical Correlates of AKI in Chinese Hospitalized Adults. Clin J Am Soc Nephrol. 2015;10:1510-1518.

     Not in our library10.2215/cjn.02140215

141. 141.

     Yang XH, Sun RH, Chen DC. Diagnosis and treatment of COVID-19: acute kidney injury cannot be ignored. Zhonghua Yi Xue Za Zhi. 2020;100:E017.

     Not in our library10.3760/cma.j.cn112137-20200229-00520

142. 142.

     Gaudry S, Hajage D, Schortgen F, Martin-Lefevre L, Pons B, Boulet E, et al. Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med. 2016;375:122-133.

     Not in our library10.1056/nejmoa1603017

143. 143.

     Barbar SD, Clere-Jehl R, Bourredjem A, Hernu R, Montini F, Bruyère R, et al. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis. N Engl J Med. 2018;379:1431-1442.

     Not in our library10.1056/nejmoa1803213

144. 144.

     Yang XH, Sun RH, Zhao MY, Chen EZ, Liu J, Wang HG, et al. Expert recommendation for novel coronavirus pneumonia patients with blood purification treatment. Natl Med J China. 2020.

     Not in our library10.3760/cma.j.cn112137-20200224-00420

145. 145.

     Chinese Society for Parenteral and Enteral Nutrition. Recommendations for parenteral and enteral nutrition therapy in critically ill COVID-19 patients. J Surg Concept Pract. 2020;25:35-39.

     Not in our library

146. 146.

     Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2018;38:48-79.

     Not in our library10.1016/j.clnu.2018.08.037

147. 147.

     Choi EY, Park DA, Park J. Calorie intake of enteral nutrition and clinical outcomes in acutely critically ill patients: a meta-analysis of randomized controlled trial. J Parenter Enteral Nutr. 2015;39:291-300.

     Not in our library10.1177/0148607114544322

148. 148.

     McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Gudielines for the provision and assessment of nutrition support therapy in the adult critically ill patient: society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N). J Parenter Enteral Nutr. 2016;40:159-211.

     Not in our library10.1177/0148607115621863

149. 149.

     Elke G, Hartl WH, Kreymann KG, Adolph M, Felbinger TW, Graf T, et al. Clinical nutrition in critical care medicine-Guideline of the German Society for Nutrition Medicine(DGEM). Clin Nutr ESPEN. 2019;33:220-275.

     Not in our library10.1016/j.clnesp.2019.05.002

150. 150.

     Zhang JY, Shao CH, Yang JH, Su JG, Qian T, Liu JF, et al. Recommendations for nutrition therapy in critically ill COVID-19 patients. Chin J Clin Med. 2020. http://kns.cnki.net/kcms/detail/31.1794. R.20200311.0958.002.html.

     Not in our library

151. 151.

     Liew MF, Siow WT, Yau YW, See KC. Safe patient transport for COVID-19. Crit Care. 2020;24:94.

     Not in our library10.1186/s13054-020-2828-4

Cited by papers we hold 5

• Case Report: The Experience of Managing a Moderate ARDS Caused by SARS-CoV-2 Omicron BA.2 Variant in Chongqing, China: Can We Do Better? · 2022
  Not checked
• Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19 · 2021
  No notice
• Prognostic Accuracy of Early Warning Scores for Clinical Deterioration in Patients With COVID-19 · 2021
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• Tracheostomy in 80 COVID-19 Patients: A Multicenter, Retrospective, Observational Study · 2020
  Not checked
• Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study · 2020
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