Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

Abstract

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy.

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Cited by papers we hold 2

• Platelets in Sepsis: An Update on Experimental Models and Clinical Data · 2019
  No notice
• Role of Platelet Mitochondria: Life in a Nucleus-Free Zone · 2019
  No notice

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