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Prediction of fluid responsiveness: an update

Xavier Monnet, Paul E. Marik, Jean-Louis Teboul

Annals of Intensive Care · 2016 · Review · CC BY-NC-ND

Abstract

In patients with acute circulatory failure, the decision to give fluids or not should not be taken lightly. The risk of overzealous fluid administration has been clearly established. Moreover, volume expansion does not always increase cardiac output as one expects. Thus, after the very initial phase and/or if fluid losses are not obvious, predicting fluid responsiveness should be the first step of fluid strategy. For this purpose, the central venous pressure as well as other "static" markers of preload has been used for decades, but they are not reliable. Robust evidence suggests that this traditional use should be abandoned. Over the last 15 years, a number of dynamic tests have been developed. These tests are based on the principle of inducing short-term changes in cardiac preload, using heart-lung interactions, the passive leg raise or by the infusion of small volumes of fluid, and to observe the resulting effect on cardiac output. Pulse pressure and stroke volume variations were first developed, but they are reliable only under strict conditions. The variations in vena caval diameters share many limitations of pulse pressure variations. The passive leg-raising test is now supported by solid evidence and is more frequently used. More recently, the end-expiratory occlusion test has been described, which is easily performed in ventilated patients. Unlike the traditional fluid challenge, these dynamic tests do not lead to fluid overload. The dynamic tests are complementary, and clinicians should choose between them based on the status of the patient and the cardiac output monitoring technique. Several methods and tests are currently available to identify preload responsiveness. All have some limitations, but they are frequently complementary. Along with elements indicating the risk of fluid administration, they should help clinicians to take the decision to administer fluids or not in a reasoned way.

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References 90

1.
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368-1377.
Not in our library10.1056/nejmoa010307
2.
Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med. 2011;39:259-265.
Not in our library10.1097/ccm.0b013e3181feeb15
3.
Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006;34:344-353.
Not in our library10.1097/01.ccm.0000194725.48928.3a
4.
Fluid balance and cardiac function in septic shock as predictors of hospital mortality · 2013
No notice
5.
Murphy CV, Schramm GE, Doherty JA, Reichley RM, Gajic O, Afessa B, et al. The importance of fluid management in acute lung injury secondary to septic shock. Chest. 2009;136:102-109.
Not in our library10.1378/chest.08-2706
6.
Rosenberg AL, Dechert RE, Park PK, Bartlett RH, Network NNA. Review of a large clinical series: association of cumulative fluid balance on outcome in acute lung injury: a retrospective review of the ARDSnet tidal volume study cohort. J Intensive Care Med. 2009;24:35-46.
Not in our library10.1177/0885066608329850
7.
Jozwiak M, Silva S, Persichini R, Anguel N, Osman D, Richard C, et al. Extravascular lung water is an independent prognostic factor in patients with acute respiratory distress syndrome. Crit Care Med. 2013;41:472-480.
Not in our library10.1097/ccm.0b013e31826ab377
8.
Kirkpatrick AW, Roberts DJ, De Waele J, Jaeschke R, Malbrain ML, De Keulenaer B, et al. Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome. Intensive Care Med. 2013;39:1190-1206.
Not in our library10.1007/s00134-013-2906-z
9.
Bouchard J, Soroko SB, Chertow GM, Himmelfarb J, Ikizler TA, Paganini EP, et al. Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int. 2009;76:422-427.
Not in our library10.1038/ki.2009.159
10.
A positive fluid balance is associated with a worse outcome in patients with acute renal failure · 2008
No notice
11.
Benes J, Kirov M, Kuzkov V, Lainscak M, Molnar Z, Voga G, et al. Fluid therapy: double-edged sword during critical care? Biomed Res Int. 2015;2015:729075.
Not in our library10.1155/2015/729075
12.
Monnet X, Pinsky MR. Predicting the determinants of volume responsiveness. Intensive Care Med. 2015;41:354-356.
Not in our library10.1007/s00134-014-3637-5
13.
Michard F, Teboul JL. Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence. Chest. 2002;121:2000-2008.
Not in our library10.1378/chest.121.6.2000
14.
Bentzer P, Griesdale DE, Boyd J, MacLean K, Sirounis D, Ayas NT. Will this hemodynamically unstable patient respond to a bolus of intravenous fluids? JAMA. 2016;316:1298-1309.
Not in our library10.1001/jama.2016.12310
15.
Hemodynamic parameters to guide fluid therapy · 2011
No notice
16.
Marik PE, Cavallazzi R. Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense. Crit Care Med. 2013;41:1774-1781.
Not in our library10.1097/ccm.0b013e31828a25fd
17.
Cecconi M, Hofer C, Teboul JL, Pettila V, Wilkman E, Molnar Z, et al. Fluid challenges in intensive care: the FENICE study: a global inception cohort study. Intensive Care Med. 2015;41:1529-1537.
Not in our library10.1007/s00134-015-3850-x
18.
Hemodynamic monitoring and management in patients undergoing high risk surgery: a survey among North American and European anesthesiologists · 2011
No notice
19.
Eskesen TG, Wetterslev M, Perner A. Systematic review including re-analyses of 1148 individual data sets of central venous pressure as a predictor of fluid responsiveness. Intensive Care Med. 2016;42:324-332.
Not in our library10.1007/s00134-015-4168-4
20.
Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study · 2013
No notice
21.
Marik PE. Iatrogenic salt water drowning and the hazards of a high central venous pressure. Ann Intensive Care. 2014;4:21.
Not in our library10.1186/s13613-014-0021-0
22.
Michard F, Boussat S, Chemla D, Anguel N, Mercat A, Lecarpentier Y, et al. Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure. Am J Respir Crit Care Med. 2000;162:134-138.
Not in our library10.1164/ajrccm.162.1.9903035
23.
Does pulse pressure variation predict fluid responsiveness in critically ill patients? A systematic review and meta-analysis · 2014
No notice
24.
Marik PE, Cavallazzi R, Vasu T, Hirani A. Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature. Crit Care Med. 2009;37:2642-2647.
Not in our library10.1097/ccm.0b013e3181a590da
25.
Cannesson M, Le Manach Y, Hofer CK, Goarin JP, Lehot JJ, Vallet B, et al. Assessing the diagnostic accuracy of pulse pressure variations for the prediction of fluid responsiveness: a “Gray Zone” approach. Anesthesiology. 2011;115:231-241.
Not in our library10.1097/aln.0b013e318225b80a
26.
Monnet X, Dres M, Ferre A, Le Teuff G, Jozwiak M, Bleibtreu A, et al. Prediction of fluid responsiveness by a continuous non-invasive assessment of arterial pressure in critically ill patients: comparison with four other dynamic indices. Br J Anaesth. 2012;109:330-338.
Not in our library10.1093/bja/aes182
27.
Monnet X, Rienzo M, Osman D, Anguel N, Richard C, Pinsky MR, et al. Esophageal Doppler monitoring predicts fluid responsiveness in critically ill ventilated patients. Intensive Care Med. 2005;31:1195-1201.
Not in our library10.1007/s00134-005-2731-0
28.
Sandroni C, Cavallaro F, Marano C, Falcone C, De Santis P, Antonelli M. Accuracy of plethysmographic indices as predictors of fluid responsiveness in mechanically ventilated adults: a systematic review and meta-analysis. Intensive Care Med. 2012;38:1429-1437.
Not in our library10.1007/s00134-012-2621-1
29.
Compton F, Hoffmann C, Zidek W, Schmidt S, Schaefer JH. Volumetric hemodynamic parameters to guide fluid removal on hemodialysis in the intensive care unit. Hemodial Int. 2007;11:231-237.
Not in our library10.1111/j.1542-4758.2007.00174.x
30.
Chu H, Wang Y, Sun Y, Wang G. Accuracy of pleth variability index to predict fluid responsiveness in mechanically ventilated patients: a systematic review and meta-analysis. J Clin Monit Comput. 2015;30:265-274.
Not in our library10.1007/s10877-015-9742-3
31.
Biais M, Cottenceau V, Petit L, Masson F, Cochard JF, Sztark F. Impact of norepinephrine on the relationship between pleth variability index and pulse pressure variations in ICU adult patients. Crit Care. 2011;15:R168.
Not in our library10.1186/cc10310
32.
Monnet X, Guerin L, Jozwiak M, Bataille A, Julien F, Richard C, et al. Pleth variability index is a weak predictor of fluid responsiveness in patients receiving norepinephrine. Br J Anaesth. 2013;110:207-213.
Not in our library10.1093/bja/aes373
33.
Song Y, Kwak YL, Song JW, Kim YJ, Shim JK. Respirophasic carotid artery peak velocity variation as a predictor of fluid responsiveness in mechanically ventilated patients with coronary artery disease. Br J Anaesth. 2014;113:61-66.
Not in our library10.1093/bja/aeu057
34.
Monge Garcia MI, Gil Cano A, Diaz Monrove JC. Brachial artery peak velocity variation to predict fluid responsiveness in mechanically ventilated patients. Crit Care. 2009;13:R142.
Not in our library10.1186/cc8027
35.
Myatra SN, Prabu SR, Divatia JV, Monnet X, Kulkarni AP, Teboul JL. The changes in pulse pressure variation or stroke volume variation after a “tidal volume challenge” reliably predict fluid responsiveness during low tidal volume ventilation. Crit Care Med. 2016 (in press).
Not in our library10.1097/ccm.0000000000002183
36.
Monnet X, Bleibtreu A, Ferré A, Dres M, Gharbi R, Richard C, et al. Passive leg raising and end-expiratory occlusion tests perform better than pulse pressure variation in patients with low respiratory system compliance. Crit Care Med. 2012;40:152-157.
Not in our library10.1097/ccm.0b013e31822f08d7
37.
Liu Y, Wei LQ, Li GQ, Yu X, Li GF, Li YM. Pulse pressure variation adjusted by respiratory changes in pleural pressure, rather than by tidal volume, reliably predicts fluid responsiveness in patients with acute respiratory distress syndrome. Crit Care Med. 2016;44:342-351.
Not in our library10.1097/ccm.0000000000001371
38.
Diaz F, Erranz B, Donoso A, Salomon T, Cruces P. Influence of tidal volume on pulse pressure variation and stroke volume variation during experimental intra-abdominal hypertension. BMC Anesthesiol. 2015;15:127.
Not in our library10.1186/s12871-015-0105-x
39.
Duperret S, Lhuillier F, Piriou V, Vivier E, Metton O, Branche P, et al. Increased intra-abdominal pressure affects respiratory variations in arterial pressure in normovolaemic and hypovolaemic mechanically ventilated healthy pigs. Intensive Care Med. 2007;33:163-171.
Not in our library10.1007/s00134-006-0412-2
40.
Jacques D, Bendjelid K, Duperret S, Colling J, Piriou V, Viale JP. Pulse pressure variation and stroke volume variation during increased intra-abdominal pressure: an experimental study. Crit Care. 2011;15:R33.
Not in our library10.1186/cc9980
41.
Mahjoub Y, Pila C, Friggeri A, Zogheib E, Lobjoie E, Tinturier F, et al. Assessing fluid responsiveness in critically ill patients: false-positive pulse pressure variation is detected by Doppler echocardiographic evaluation of the right ventricle. Crit Care Med. 2009;37:2570-2575.
Not in our library10.1097/ccm.0b013e3181a380a3
42.
Preau S, Dewavrin F, Demaeght V, Chiche A, Voisin B, Minacori F, et al. The use of static and dynamic haemodynamic parameters before volume expansion: a prospective observational study in six French intensive care units. Anaesth Crit Care Pain Med. 2015;35:93-102.
Not in our library10.1016/j.accpm.2015.08.003
43.
Fischer MO, Dechanet F, du Cheyron D, Gerard JL, Hanouz JL, Fellahi JL. Evaluation of the knowledge base of French intensivists and anaesthesiologists as concerns the interpretation of respiratory arterial pulse pressure variation. Anaesth Crit Care Pain Med. 2015;34:29-34.
Not in our library10.1016/j.accpm.2014.06.001
44.
Vignon P, Repesse X, Begot E, Leger J, Jacob C, Bouferrache K, et al. Comparison of echocardiographic indices used to predict fluid responsiveness in ventilated patients. Am J Respir Crit Care Med. 2016.
Not in our library10.1164/rccm.201604-0844oc
45.
Feissel M, Michard F, Faller JP, Teboul JL. The respiratory variation in inferior vena cava diameter as a guide to fluid therapy. Intensive Care Med. 2004;30:1834-1837.
Not in our library10.1007/s00134-004-2233-5
46.
Machare-Delgado E, Decaro M, Marik PE. Inferior vena cava variation compared to pulse contour analysis as predictors of fluid responsiveness: a prospective cohort study. J Intensive Care Med. 2011;26:116-124.
Not in our library10.1177/0885066610384192
47.
Zhang Z, Xu X, Ye S, Xu L. Ultrasonographic measurement of the respiratory variation in the inferior vena cava diameter is predictive of fluid responsiveness in critically ill patients: systematic review and meta-analysis. Ultrasound Med Biol. 2014;40:845-853.
Not in our library10.1016/j.ultrasmedbio.2013.12.010
48.
Charbonneau H, Riu B, Faron M, Mari A, Kurrek MM, Ruiz J, et al. Predicting preload responsiveness using simultaneous recordings of inferior and superior vena cavae diameters. Crit Care. 2014;18:473.
Not in our library10.1186/s13054-014-0473-5
49.
Juhl-Olsen P, Vistisen ST, Christiansen LK, Rasmussen LA, Frederiksen CA, Sloth E. Ultrasound of the inferior vena cava does not predict hemodynamic response to early hemorrhage. J Emerg Med. 2013;45:592-597.
Not in our library10.1016/j.jemermed.2013.03.044
50.
Corl K, Napoli AM, Gardiner F. Bedside sonographic measurement of the inferior vena cava caval index is a poor predictor of fluid responsiveness in emergency department patients. Emerg Med Australas. 2012;24:534-539.
Not in our library10.1111/j.1742-6723.2012.01596.x
51.
Lanspa MJ, Grissom CK, Hirshberg EL, Jones JP, Brown SM. Applying dynamic parameters to predict hemodynamic response to volume expansion in spontaneously breathing patients with septic shock. Shock. 2013;39:155-160.
Not in our library10.1097/shk.0b013e31827f1c6a
52.
Does inferior vena cava respiratory variability predict fluid responsiveness in spontaneously breathing patients? · 2015
No notice
53.
Guarracino F, Ferro B, Forfori F, Bertini P, Magliacano L, Pinsky MR. Jugular vein distensibility predicts fluid responsiveness in septic patients. Crit Care. 2014;18:647.
Not in our library10.1186/s13054-014-0647-1
54.
Boulain T, Achard JM, Teboul JL, Richard C, Perrotin D, Ginies G. Changes in BP induced by passive leg raising predict response to fluid loading in critically ill patients. Chest. 2002;121:1245-1252.
Not in our library10.1378/chest.121.4.1245
55.
Monnet X, Rienzo M, Osman D, Anguel N, Richard C, Pinsky MR, et al. Passive leg raising predicts fluid responsiveness in the critically ill. Crit Care Med. 2006;34:1402-1407.
Not in our library10.1097/01.ccm.0000215453.11735.06
56.
Jabot J, Teboul JL, Richard C, Monnet X. Passive leg raising for predicting fluid responsiveness: importance of the postural change. Intensive Care Med. 2009;35:85-90.
Not in our library10.1007/s00134-008-1293-3
57.
Guerin L, Teboul JL, Persichini R, Dres M, Richard C, Monnet X. Effects of passive leg raising and volume expansion on mean systemic pressure and venous return in shock in humans. Crit Care. 2015;19:411.
Not in our library10.1186/s13054-015-1115-2
58.
Cherpanath TG, Hirsch A, Geerts BF, Lagrand WK, Leeflang MM, Schultz MJ, et al. Predicting fluid responsiveness by passive leg raising: a systematic review and meta-analysis of 23 clinical trials. Crit Care Med. 2016;44:981-991.
Not in our library10.1097/ccm.0000000000001556
59.
Monnet X, Marik P, Teboul JL. Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis. Intensive Care Med. 2016.
Not in our library10.1007/s00134-015-4134-1
60.
Campaign SS. Updated bundles in response to new evidence. Available from: http://www.survivingsepsis.org/bundles/Pages/default.aspx.
Not in our library
61.
Cecconi M, De Backer D, Antonelli M, Beale R, Bakker J, Hofer C, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med. 2014;40:1795-1815.
Not in our library10.1007/s00134-014-3525-z
62.
Passive leg raising: five rules, not a drop of fluid! · 2015
No notice
63.
Monnet X, Teboul JL. Passive leg raising. Intensive Care Med. 2008;34:659-663.
Not in our library10.1007/s00134-008-0994-y
64.
Marik PE, Levitov A, Young A, Andrews L. The use of bioreactance and carotid Doppler to determine volume responsiveness and blood flow redistribution following passive leg raising in hemodynamically unstable patients. Chest. 2013;143:364-370.
Not in our library10.1378/chest.12-1274
65.
Preau S, Saulnier F, Dewavrin F, Durocher A, Chagnon JL. Passive leg raising is predictive of fluid responsiveness in spontaneously breathing patients with severe sepsis or acute pancreatitis. Crit Care Med. 2010;38:989-990.
Not in our library10.1097/ccm.0b013e3181c8fe7a
66.
Kupersztych-Hagege E, Teboul JL, Artigas A, Talbot A, Sabatier C, Richard C, et al. Bioreactance is not reliable for estimating cardiac output and the effects of passive leg raising in critically ill patients. Br J Anaesth. 2013;111:961-966.
Not in our library10.1093/bja/aet282
67.
Fellahi JL, Fischer MO, Dalbera A, Massetti M, Gerard JL, Hanouz JL. Can endotracheal bioimpedance cardiography assess hemodynamic response to passive leg raising following cardiac surgery? Ann Intensive Care. 2012;2:26.
Not in our library10.1186/2110-5820-2-26
68.
Keller G, Cassar E, Desebbe O, Lehot JJ, Cannesson M. Ability of pleth variability index to detect hemodynamic changes induced by passive leg raising in spontaneously breathing volunteers. Crit Care. 2008;12:R37.
Not in our library10.1186/cc6822
69.
Young A, Marik PE, Sibole S, Grooms D, Levitov A. Changes in end-tidal carbon dioxide and volumetric carbon dioxide as predictors of volume responsiveness in hemodynamically unstable patients. J Cardiothorac Vasc Anesth. 2013;27:681-684.
Not in our library10.1053/j.jvca.2012.09.025
70.
Monnet X, Bataille A, Magalhaes E, Barrois J, Le Corre M, Gosset C, et al. End-tidal carbon dioxide is better than arterial pressure for predicting volume responsiveness by the passive leg raising test. Intensive Care Med. 2013;39:93-100.
Not in our library10.1007/s00134-012-2693-y
71.
Monge Garcia MI, Gil Cano A, Gracia Romero M, Monterroso Pintado R, Perez Madueno V, Diaz Monrove JC. Non-invasive assessment of fluid responsiveness by changes in partial end-tidal CO2 pressure during a passive leg-raising maneuver. Ann Intensive Care. 2012;2:9.
Not in our library10.1186/2110-5820-2-9
72.
Xiao-Ting W, Hua Z, Da-Wei L, Hong-Min Z, Huai-Wu H, Yun L, et al. Changes in end-tidal CO2 could predict fluid responsiveness in the passive leg raising test but not in the mini-fluid challenge test: a prospective and observational study. J Crit Care. 2015;30:1061-1066.
Not in our library10.1016/j.jcrc.2015.05.019
73.
Mahjoub Y, Touzeau J, Airapetian N, Lorne E, Hijazi M, Zogheib E, et al. The passive leg-raising maneuver cannot accurately predict fluid responsiveness in patients with intra-abdominal hypertension. Crit Care Med. 2010;38:1824-1829.
Not in our library10.1097/ccm.0b013e3181eb3c21
74.
Malbrain ML, Reuter DA. Assessing fluid responsiveness with the passive leg raising maneuver in patients with increased intra-abdominal pressure: be aware that not all blood returns! Crit Care Med. 2010;38:1912-1915.
Not in our library10.1097/ccm.0b013e3181f1b6a2
75.
Monnet X, Osman D, Ridel C, Lamia B, Richard C, Teboul JL. Predicting volume responsiveness by using the end-expiratory occlusion in mechanically ventilated intensive care unit patients. Crit Care Med. 2009;37:951-956.
Not in our library10.1097/ccm.0b013e3181968fe1
76.
Silva S, Jozwiak M, Teboul JL, Persichini R, Richard C, Monnet X. End-expiratory occlusion test predicts preload responsiveness independently of positive end-expiratory pressure during acute respiratory distress syndrome. Crit Care Med. 2013;41:1692-1701.
Not in our library10.1097/ccm.0b013e31828a2323
77.
Jozwiak M, Teboul JL, Richard C, Monnet X. Predicting fluid responsiveness with echocardiography by combining end-expiratory and inspiratory occlusions (abstract). Ann Intensive Care. 2016 (in press).
Not in our library
78.
Tusman G, Groisman I, Maidana GA, Scandurra A, Arca JM, Bohm SH, et al. The sensitivity and specificity of pulmonary carbon dioxide elimination for noninvasive assessment of fluid responsiveness. Anesth Analg. 2015;122:1404-1411.
Not in our library10.1213/ane.0000000000001047
79.
Preisman S, Kogan S, Berkenstadt H, Perel A. Predicting fluid responsiveness in patients undergoing cardiac surgery: functional haemodynamic parameters including the respiratory systolic variation test and static preload indicators. Br J Anaesth. 2005;95:746-755.
Not in our library10.1093/bja/aei262
80.
Trepte CJ, Eichhorn V, Haas SA, Stahl K, Schmid F, Nitzschke R, et al. Comparison of an automated respiratory systolic variation test with dynamic preload indicators to predict fluid responsiveness after major surgery. Br J Anaesth. 2013;111:736-742.
Not in our library10.1093/bja/aet204
81.
Vincent JL, Weil MH. Fluid challenge revisited. Crit Care Med. 2006;34:1333-1337.
Not in our library10.1097/01.ccm.0000214677.76535.a5
82.
Monnet X, Letierce A, Hamzaoui O, Chemla D, Anguel N, Osman D, et al. Arterial pressure allows monitoring the changes in cardiac output induced by volume expansion but not by norepinephrine*. Crit Care Med. 2011;39:1394-1399.
Not in our library10.1097/ccm.0b013e31820edcf0
83.
Pierrakos C, Velissaris D, Scolletta S, Heenen S, De Backer D, Vincent JL. Can changes in arterial pressure be used to detect changes in cardiac index during fluid challenge in patients with septic shock? Intensive Care Med. 2012;38:422-428.
Not in our library10.1007/s00134-011-2457-0
84.
Muller L, Toumi M, Bousquet PJ, Riu-Poulenc B, Louart G, Candela D, et al. An increase in aortic blood flow after an infusion of 100 ml colloid over 1 minute can predict fluid responsiveness: the mini-fluid challenge study. Anesthesiology. 2011;115:541-547.
Not in our library10.1097/aln.0b013e318229a500
85.
Wu Y, Zhou S, Zhou Z, Liu B. A 10-second fluid challenge guided by transthoracic echocardiography can predict fluid responsiveness. Crit Care. 2014;18:R108.
Not in our library10.1186/cc13891
86.
Aya HD, Rhodes A, Ster IC, Cecconi M. Haemodynamic effect of different doses of fluids for a fluid challenge: a quasi-randomised controlled study. Crit Care Med. 2016 (in press).
Not in our library10.1097/ccm.0000000000002067
87.
Lira A, Pinsky MR. Choices in fluid type and volume during resuscitation: impact on patient outcomes. Ann Intensive Care. 2014;4:38.
Not in our library10.1186/s13613-014-0038-4
88.
Extravascular lung water in critical care: recent advances and clinical applications · 2015
No notice
89.
Teboul JL, Monnet X. Detecting volume responsiveness and unresponsiveness in intensive care unit patients: two different problems, only one solution. Crit Care. 2009;13:175.
Not in our library10.1186/cc7979
90.
Monnet X, Cipriani F, Camous L, Sentenac P, Dres M, Krastinova E, et al. The passive leg raising test to guide fluid removal in critically ill patients. Ann Intensive Care. 2016;6:46.
Not in our library10.1186/s13613-016-0149-1

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