DNA in extracellular vesicles: from evolution to its current application in health and disease
Jamal Ghanam, Venkatesh Kumar Chetty, Lennart Barthel and 3 more
Cell & Bioscience · 2022
doi:10.1186/s13578-022-00771-0 (opens in a new tab)
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Abstract
Highlights Protecting DNA in membrane vesicles seems to be a conserved phenomenon for the horizontal genetic flux between prokaryotes and lower eukaryotes. Capturing and analyzing this vesicular DNA enables quick and non-invasive monitoring of natural ecosystems. Cancer-derived extracellular vesicles containing DNA open up novel directions in cell-to-cell communication and therefore disease monitoring. Complex and fluctuating conditions of the tumor microenvironment, mimicking natural ecosystems, could favor EV-DNA release, mediating tumor multi-clonal evolution and providing survival benefits.
Abstract licence: CC BY-NC-ND
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