Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
Xinyuan Wang, Kimberly M. Christian, Hongjun Song and 1 more
Genome Medicine · 2018
doi:10.1186/s13073-018-0518-5 (opens in a new tab)
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Abstract
Editorial summary Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-based models have allowed mechanistic investigations of synaptic dysfunction in pathological processes.
Abstract licence: CC BY-NC-ND
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