The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis

Abstract

Keywords: Hypoalbuminemia, COVID-19, SARS-CoV-2, Severe diseaseThe coronavirus disease 2019 (COVID-19) pandemic necessitates identifying laboratory markers to assist the clinicians in early recognition of severe disease [1].Given the unclear association of hypoalbuminemia and severe COVID-19, we conducted a systematic review and metaanalysis to answer this.An extensive literature search of PubMed/MEDLINE, Embase, Cochrane, and Web of Science was conducted through April 3, 2020, using search strategy created by an experienced librarian (W.L.S).Two independent reviewers (M.A. and R.F.) performed screening and data extraction of articles.Articles were selected if they reported data on COVID-19 patients with respect to hypoalbuminemia.Discrepancy in screening/data collection was resolved through mutual discussion.Random-effects meta-analysis was conducted, and odds ratio (OR) and mean difference (MD) for proportional and continuous variables were computed, respectively.For each outcome, forest plot, 95% confidence interval (CI), p value ( 50% considered as substantial heterogeneity) was generated using Open Meta Analyst (CEBM, Oxford, UK).Severe COVID-19 was defined as respiratory distress (with either rate ≥ 30/min, oxygen saturation ≤ 93% at rest, and/or PaO2/FiO2 ≤ 300 mmHg), ICU admission, and/or death [1].Hypoalbuminemia was reported based on reference laboratory parameters for each study.

Cited by papers we hold 3

• Sociodemographic and clinical features predictive of SARS-CoV-2 test positivity across healthcare visit-types. · 2021
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• Biomarkers in COVID-19: An Up-To-Date Review · 2021
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• Hypoalbuminemia as Surrogate and Culprit of Infections · 2021
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