The impact of the temporary suspension of national cancer screening programmes due to the COVID-19 epidemic on the diagnosis of breast and colorectal cancer in the Netherlands

1To the Editor,

2The chaos wreaked by COVID-19 catalysed a notable decrease in cancer diagnoses in the Netherlands compared with the period preceding the COVID-19 outbreak. At the time when these findings were published, provisional data from the Netherlands Cancer Registry (NCR) on cancer diagnoses were available up to 12 April 2020. Therefore, the impact of the temporary halt of national population screening programmes for breast and colorectal cancer—which were halted as of 16 March 2020—could not yet be disentangled with the comparatively short observation period. These programmes were halted to ease the burden on health-care services overwhelmed by the surge of COVID-19 patients, to reallocate personal protective equipment (PPE) to health care staff tackling COVID-19, and to mitigate the spread of COVID-19.

3The demand for critical COVID-19 care steadily decreased in the Netherlands since early April 2020. Consequently, hospital capacity for the diagnostic work-up of suspected cancer cases gradually re-established and PPE became increasingly available for a broad range of health care workers (e.g. radiographers and colonoscopists). Also, cancer screening units and waiting rooms were reorganised to minimise contracting COVID-19 in such environments. Therefore, invitations to screening programmes for colorectal and breast cancer gradually recommenced—albeit with limited operating and workforce capacity—as of mid-May 2020 and mid-June 2020, respectively.

4With more recent data available on cancer diagnoses up to 4 October 2020, we assessed the impact of the temporarily suspended national screening programmes on the initial pathological notification of ductal carcinoma in situ (DCIS) and invasive breast cancer—hereafter collectively designated as breast cancer—and colorectal cancer in the Netherlands.

5We selected patients diagnosed between 6 January 2020 and 4 October 2020 from the NCR that relies on pathological cancer notifications via the Nationwide Histopathology and Cytopathology Data Network and Archive. Of note, colorectal adenomas are not ascertained in the NCR. The expected number of newly diagnosed malignancies per calendar week during the study period was predicted using a dynamic harmonic regression model with ARIMA error components based on the observed weekly trends in cancer diagnoses in the period 2010–2019. The Additional file 1 provides methodological details.

6Breast cancer diagnoses among women aged < 50 or > 74 years (i.e. those not invited for biennial mammography screening) became significantly lower—as compared to the expected number of diagnoses—as of mid-March (Fig. 1a), owing to changes in health-seeking behaviour and referral practices amid the early stages of the COVID-19 epidemic. Encouragingly enough—as of early May—the observed number of diagnoses in these age groups was reached and virtually remained at the level of the expected values. The number of breast cancer diagnoses among women aged 50–74 years (i.e. those invited for biennial mammography screening) showed a very steep decline as of early April—that is, 2 weeks after the suspension of breast cancer screening (Fig. 1b). Thereafter, the number of diagnoses remained lower than the expected number of diagnoses until mid–late June. The trends described herein were commensurate between invasive breast cancer and DCIS (Additional file 1).

7The number of colorectal cancer diagnoses among individuals aged < 55 or > 75 years (i.e. those not invited for biennial faecal immunochemical testing) was significantly lower than the expected numbers in the first weeks of April (Fig. 1c). Thereafter, it reached and remained at the expected level. In contrast, the number of colorectal cancer diagnoses among individuals aged 55–75 years (i.e. those invited for biennial faecal immunochemical testing) remained slightly lower than the expected number of diagnoses as of early May—that is, 6 weeks after the halt of colorectal cancer screening (Fig. 1d). The observed number of diagnoses ultimately reached the level of the expected values since late June.

8The information gleaned by the NCR provides clues that—on top of changes in health-seeking behaviour and referral practices—the temporary halt of national population screening programmes exacerbated fewer breast and colorectal cancer diagnoses in age groups eligible for cancer screening programmes. We cannot yet establish whether diagnostic delays due to the COVID-19 crisis resulted in stage migration. This issue provoked passionate debates—based on the best available literature—about the magnitude of neoplastic progression and cancer deaths amid the COVID-19 pandemic, especially in the light of the extent of the delay. The decreased diagnostic scrutiny of cancer amid the COVID-19 pandemic might support resolving controversies regarding overdiagnosis of particular early-stage cancers that would not otherwise become clinically apparent. To address the concerns surrounding the collateral damage of COVID-19 on oncological care in the Netherlands in more detail, information on a variety of patient, tumour, treatment, and survival characteristics will be garnered in the NCR. These data can be compared with data from previous years to assess whether temporal changes in stage distribution and first-line treatment occurred during the COVID-19 crisis.