Abstracts from the 22nd International Symposium on Signal Transduction at the Blood–Brain Barriers

Discoveries leading to an improved understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked dismissal of the existence of immune privilege of the CNS.Recent rediscoveries of lymphatic vessels within the dura mater surrounding the brain by modern live cell imaging technologies have revived this discussion.Understanding immune privilege of the CNS requires intimate knowledge of its unique anatomy.Employing in vivo and in vitro studies on immune cell migration into the CNS during immune surveillance and neuroinflammation using live cell imaging we have explored the anatomical routes and cellular and molecular mechanisms involved in immune cell trafficking to the CNS.Our findings underscore that endothelial, epithelial and glial brain barriers establish compartments within the CNS that differ strikingly with regard to their accessibility to immune cell subsets.

Abstract licence: CC BY-NC-ND

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