Bactericidal effects and accelerated wound healing using Tb4O7 nanoparticles with intrinsic oxidase-like activity

Nanomaterials that exhibit intrinsic enzyme-like characteristics have shown great promise as potential antibacterial agents. However, many of them exhibit inefficient antibacterial activity and biosafety problems that limit their usefulness. The development of new nanomaterials with good biocompatibility and rapid bactericidal effects is therefore highly desirable. Here, we show a new type of terbium oxide nanoparticles (Tb 4 O 7 NPs) with intrinsic oxidase-like activity for in vitro and in vivo antibacterial application. We find that Tb 4 O 7 NPs can quickly oxidize a series of organic substrates in the absence of hydrogen peroxide. The oxidase-like capacity of Tb 4 O 7 NPs allows these NPs to consume antioxidant biomolecules and generate reactive oxygen species to disable bacteria in vitro. Moreover, the in vivo experiments showed that Tb 4 O 7 NPs are efficacious in wound-healing and are protective of normal tissues. Our results reveal that Tb 4 O 7 NPs have intrinsic oxidase-like activity and show effective antibacterial ability both in vitro and in vivo. These findings demonstrate that Tb 4 O 7 NPs are effective antibacterial agents and may have a potential application in wound healing.

Abstract licence: CC BY-NC-ND

1. 4.

   Effects of Hydrogen Peroxide on Wound Healing in Mice in Relation to Oxidative Damage · 2012

2. 26.

   Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria · 2018

3. 27.

   ROS scavenging Mn 3 O 4 nanozymes for in vivo anti-inflammation · 2018

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